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Peptide chain elongation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-156902

PubChem

R-HSA-156902

Description

The mechanism of a peptide bond requires the movement of three protons. First the deprotonation of the ammonium ion generates a reactive amine, allowing a nucleophilic attack on the carbonyl group. This is followed by the loss of a proton from the reaction intermediate, only to be taken up by the oxygen on the leaving group (from the end of the amino acid chain bound to the tRNA in the P-site). The peptide bond formation results in the net loss of one water molecule, leaving a deacylated-tRNA in the P-site, and a nascent polypeptide chain one amino acid larger in the A-site.
For the purpose of illustration, the figures used in the section show one amino acid being added to a peptidyl-tRNA with a growing peptide chain.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 54 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P05387	Large ribosomal subunit protein P2	D11S2243E RPLP2 RPP2	view
P05388	Large ribosomal subunit protein uL10	RPLP0	view
P08708	Small ribosomal subunit protein eS17	RPS17 RPS17L	view
P13639	Elongation factor 2	EEF2 EF2	view
P15880	Small ribosomal subunit protein uS5	RPS2 RPS4	view
P18077	Large ribosomal subunit protein eL33	GIG33 RPL35A	view
P18621	Large ribosomal subunit protein uL22	RPL17	view
P23396	Small ribosomal subunit protein uS3	OK/SW-cl.26 RPS3	view
P25398	Small ribosomal subunit protein eS12	RPS12	view
P26373	Large ribosomal subunit protein eL13	BBC1 OK/SW-cl.46 RPL13	view

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