Macroautophagy

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101ADPMTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101ATPMTORC1:Ragulator:Rag:GNP:RHEB:GTPInactive mTORC1 complexp-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101BECN1 complexAMBRA1:DYNLL1,DYNLL2:BECN1 complexAMBRA1:DYNLL1,DYNLL2Beclin-1 complexPI3PPIATG12:ATG7:CysO572-ATG7ATG12:ATG7:CysO572-ATG7:ATG10ATG10ATG7 dimer:GlyK166-ATG10:ATG12ATG7 dimerATG12:GlyK166-ATG10ATG12:GlyK166-ATG10:ATG5ATG10:GlyK130-ATG5:ATG12LC3 family precursorsLC3 familyATG3CysO572-ATG7-LC3:ATG7:ATG3CysO572-ATG7-LC3:ATG7CysO264-ATG3-LC3:ATG7 dimerCysO264-ATG3-LC3ULK complexMTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101MTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:RHEB:GTPULK complexPiBECN1 complex:p-AMBRA1:DYNLL1,DYNLL2AMBRA1DLCsBeclin-1 complexPI3PWIPI1,WIPI2,(WDR45,WDR45B):PI3PWIPI1,WIPI2,(WDR45,WDR45B)ATG12:ATG7 dimerATG12GlyK130-ATG5:ATG12ATG16L1 complexATG16L1LC3:PEPEp-AMPK heterotrimer:AMPAMBRA1p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101Beclin-1 complexATG5ATG16L1 complex:WIPI2:PI(3,5)P2WIPI2:PI(3,5)P2LC3:PE
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025