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DDX58/IFIH1-mediated induction of interferon-alpha/beta

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-168928

PubChem

R-HSA-168928

Description

RIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I, DDX58) and melanoma differentiation associated gene 5 (MDA5, IFIH1) are RNA helicases that recognize viral double-stranded RNA (dsRNA) present within the cytoplasm (Yoneyama M & Fujita T 2007, 2008). Upon viral infection dsRNA is generated by positive-strand RNA virus families such as Flaviviridae and Coronaviridae, negative-strand RNA virus families including Orthomyxoviridae and Paramyxoviridae, and DNA virus families such as Herpesviridae and Adenoviridae (Weber F et al. 2006; Son KN et al. 2015). Functionally RIG-I (DDX58) and MDA5 (IFIH1) positively regulate the IFN genes in a similar fashion, however they differ in their response to different viral species. DDX58 (RIG-I) is essential for detecting influenza virus, Sendai virus, VSV and Japanese encephalitis virus (JEV), whereas IFIH1 (MDA5) is essential in sensing encephalomyocarditis virus (EMCV), Mengo virus and Theiler's virus, all of which belong to the picornavirus family. RIG-I and MDA5 signalling results in the activation of IKK epsilon and (TKK binding kinase 1) TBK1, two serine/threonine kinases that phosphorylate interferon regulatory factor 3 and 7 (IRF3 and IRF7). Upon phosphorylation, IRF3 and IRF7 translocate to the nucleus and subsequently induce interferon alpha (IFNA) and interferon beta (IFNB) gene transcription (Yoneyama M et al. 2004; Yoneyama M & Fujita T 2007, 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 10** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O95786	Antiviral innate immune response receptor RIG-I	DDX58 RIGI	view
P07900	Heat shock protein HSP 90-alpha	HSP90A HSP90AA1 HSPC1 HSPCA	view
P08238	Heat shock protein HSP 90-beta	HSP90AB1 HSP90B HSPC2 HSPC3 HSPCB	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view
Q7Z434	Mitochondrial antiviral-signaling protein	IPS1 KIAA1271 MAVS VISA	view
Q86UT6	NLR family member X1	NLRX1 NOD5 NOD9	view
Q86WI3	Protein NLRC5	NLRC5 NOD27 NOD4	view
Q8IUD6	E3 ubiquitin-protein ligase RNF135	L13 RNF135	view
Q9UII4	E3 ISG15--protein ligase HERC5	CEB1 CEBP1 HERC5	view

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