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APC/C:Cdc20 mediated degradation of mitotic proteins

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-176409

PubChem

R-HSA-176409

Description

Following phosphorylation of the APC/C core subunits by mitotic kinases, the activating protein, Cdc20 is recruited to the APC and promotes the multiubiquitination and subsequent degradation of the mitotic cyclins (Cyclin A and Cyclin B) as well as the protein securin which functions in sister chromatid cohesion. Timely degradation of these proteins is essential for sister chromatid separation and the proper timing of exit from mitosis (See Zachariae and Nasmyth, 1999). Cdc20 is degraded late in mitosis (Reviewed in Owens and Hoyt, 2005)

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43684	Mitotic checkpoint protein BUB3	BUB3	view
O60566	Mitotic checkpoint serine/threonine-protein kinase BUB1 beta	BUB1B BUBR1 MAD3L SSK1	view
P30260	Cell division cycle protein 27 homolog	ANAPC3 CDC27 D0S1430E D17S978E	view
Q13042	Cell division cycle protein 16 homolog	ANAPC6 CDC16	view
Q9H1A4	Anaphase-promoting complex subunit 1	ANAPC1 TSG24	view
Q9UJX2	Cell division cycle protein 23 homolog	ANAPC8 CDC23	view
Q9UJX3	Anaphase-promoting complex subunit 7	ANAPC7 APC7	view

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