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Synthesis of 12-eicosatetraenoic acid derivatives

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2142712

PubChem

R-HSA-2142712

Description

The 12-eicosatetraenoic acids: 12-hydroperoxy-eicosatetraenoate (12-HpETE), 12-hydroxyeicosatetraenoate (12-HETE) and 12-oxo-eicosatetraenoate (12-oxoETE) are formed after the initial step of arachidonate oxidation by the arachidonate 12 and 15 lipoxygenases (ALOX12, ALOX12B and ALOX15 respectively). This part of the pathway is bifurcated at the level of 12S-hydroperoxy-eicosatetraenoate (12S-HpETE), which can either be reduced to 12S-hydro-eicosatetraenoate (12S-HETE) or converted to hepoxilins (Buczynski et al. 2009, Vance & Vance 2008).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying 1 entry
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P18054	Polyunsaturated fatty acid lipoxygenase ALOX12	12LO ALOX12 LOG12	view

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