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Stimuli-sensing channels

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2672351

PubChem

R-HSA-2672351

Description

Ion channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et al. 2012, Deval et al. 2010) and the transient receptor potential channels (TRPCs) (Takahashi et al. 2012, Numata et al. 2011 in "TRP Channels" Zhu, MX editor, CRC Press, 2011, Ramsey et al. 2006, Montell 2005). Many channels are sensitive to changes in calcium (Ca2+) levels, both inside and outside the cell. Examples are protein tweety homologs 2 and 3 (TTYH2, 3) (Suzuki 2006), bestrophins 1-4 (BEST1-4) (Sun et al. 2002, Tsunenari et al. 2003, Kunzelmann et al. 2009, Hartzell et al. 2008) and ryanodine receptor tetramers (RYRs) (Beard et al. 2009).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 52 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A1A5B4	Anoctamin-9	ANO9 PIG5 TMEM16J TP53I5	view
A8K7I4	Calcium-activated chloride channel regulator 1	CACC1 CLCA1	view
O00476	Sodium-dependent phosphate transport protein 4	NPT4 SLC17A3	view
O14958	Calsequestrin-2	CASQ2	view
P04049	RAF proto-oncogene serine/threonine-protein kinase	RAF RAF1	view
P21817	Ryanodine receptor 1	RYDR RYR1	view
P27105	Stomatin	BND7 EPB72 STOM	view
P31415	Calsequestrin-1	CASQ CASQ1	view
P37088	Epithelial sodium channel subunit alpha	SCNN1 SCNN1A	view
P51168	Epithelial sodium channel subunit beta	SCNN1B	view

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