POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
NANOGPOU5F1:SOX2:NANOG:DPPA4 geneSOX2OCT3DPPA4 geneDPPA4EPHA1 geneOCT4:SOX2:NANOG:EPHA1 geneEPHA1OCT4:SOX2:NANOG:FGF2 geneFGF2 geneFGF2OCT4:SOX2:NANOG:FOXD3 geneFOXD3 geneFOXD3SALL1 geneOCT4:SOX2:NANOG:SALL1 geneSALL1STAT3 geneOCT4:SOX2:NANOG:STAT3 geneSTAT3TDGF1 genePOU5F1:SOX2:NANOG:TDGF1 geneTDGF1ZIC3 geneOCT4:SOX2:NANOG:ZIC3 geneZIC3
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 7 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P13385 Protein Cripto
  • CRIPTO
  • CRIPTO-1
  • TDGF1
view
P21709 Ephrin type-A receptor 1
  • EPH
  • EPHA1
  • EPHT
  • EPHT1
view
P40763 Signal transducer and activator of transcription 3
  • APRF
  • STAT3
view
P48431 Transcription factor SOX-2
  • SOX2
view
Q01860 POU domain, class 5, transcription factor 1
  • OCT3
  • OCT4
  • OTF3
  • POU5F1
view
Q9NSC2 Sal-like protein 1
  • SAL1
  • SALL1
  • ZNF794
view
Q9UJQ4 Sal-like protein 4
  • SALL4
  • ZNF797
view
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025