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POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-2892247

PubChem

R-HSA-2892247

Description

POU5F1 (OCT4), SOX2, and NANOG bind elements in the promoters of target genes. The target genes of each transcription factor overlap extensively: POU5F1, SOX2, and NANOG co-occupy at least 353 genes (Boyer et al. 2005). About half of POU5F1 targets also bind SOX2 and about 90% of these also bind NANOG (Boyer et al. 2005). Upon binding the transcription factors activate expression of one subset of target genes and repress another subset (Kim et al. 2006, Matoba et al. 2006, Player et al. 2006, Babaie et al. 2007). The targets listed in this module are those that have been described as composing activated genes in the core transcriptional network of pluripotent stem cells (Assou et al. 2007, Chavez et al. 2009, Jung et al. 2010). Inferences from mouse to human have been made with caution because of significant differences between the two species (Ginis et al. 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P13385	Protein Cripto	CRIPTO CRIPTO-1 TDGF1	view
P21709	Ephrin type-A receptor 1	EPH EPHA1 EPHT EPHT1	view
P40763	Signal transducer and activator of transcription 3	APRF STAT3	view
P48431	Transcription factor SOX-2	SOX2	view
Q01860	POU domain, class 5, transcription factor 1	OCT3 OCT4 OTF3 POU5F1	view
Q9NSC2	Sal-like protein 1	SAL1 SALL1 ZNF794	view
Q9UJQ4	Sal-like protein 4	SALL4 ZNF797	view

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