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MIRAGE
IRE1alpha activates chaperones

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
unfolded proteinERN1BiP:Unfolded ProteinIRE1:BiPIRE1 dimerp-S724-IRE1 dimerADPATPp-S724-IRE1 dimer:ADPXbp1 mRNA (unspliced)Xbp1 mRNA (spliced)XBP1-2
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 2 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O75460 Serine/threonine-protein kinase/endoribonuclease IRE1
  • ERN1
  • IRE1
 view
P11021 Endoplasmic reticulum chaperone BiP
  • GRP78
  • HSPA5
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If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
a simple tooltip
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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025