SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
NRP1NRP1:PlexinA1-4:FARP2:FYNFARP2Plexin-A1-4:FYNSema3A dimerSema3A:Nrp-1:Plexin A:FynFESSema3A:NRP-1:pPlexin-A:Fyn:FesATPADPRAC1:GDPGDPGTPRAC1:GTPSema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTPSema3A:Nrp-1:pPlexinA:Fyn:Fes:Rac-1-GTP:Rnd1RND1:GTPR-Ras-GTPPiR-Ras-GDPPIP5K1gamma:Talin-1TLN1FARP2:PIP5KIgamma
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
Displaying all 9 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
O14786 Neuropilin-1
  • NRP
  • NRP1
  • VEGF165R
view
O60331 Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
  • KIAA0589
  • PIP5K1C
view
O75051 Plexin-A2
  • KIAA0463
  • OCT
  • PLXN2
  • PLXNA2
view
P51805 Plexin-A3
  • PLXN4
  • PLXNA3
  • SEX
view
P63000 Ras-related C3 botulinum toxin substrate 1
  • RAC1
  • TC25
view
Q14563 Semaphorin-3A
  • SEMA3A
  • SEMAD
view
Q9HCM2 Plexin-A4
  • KIAA1550
  • PLXNA4
  • PLXNA4A
  • PLXNA4B
view
Q9UIW2 Plexin-A1
  • NOV
  • PLXN1
  • PLXNA1
view
Q9Y490 Talin-1
  • KIAA1027
  • TLN
  • TLN1
view
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025