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Sodium/Calcium exchangers

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-425561

PubChem

R-HSA-425561

Description

Calcium ions are used by cells as ubiquitous signalling molecules that control diverse physiological events. Three mammalian gene families control Ca2+ transport across plasma membranes and intracellular compartments (Lytton J, 2007). They are the Na+/Ca2+ exchanger family designated NCX (SLC8) (three members NCX1-3) (Quednau BD et al, 2004), the Na+/Ca2+-K+ exchanger family designated NCKX (SLC24) (five members NCKX1-5) (Schnetkamp PP, 2004) and a Ca2+/cation exchanger (NCKX6, NCLX) whose physiological function remains unclear.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60721	Sodium/potassium/calcium exchanger 1	KIAA0702 NCKX1 SLC24A1	view
P32418	Sodium/calcium exchanger 1	CNC NCX1 SLC8A1	view
P57103	Sodium/calcium exchanger 3	NCX3 SLC8A3	view
Q6J4K2	Mitochondrial sodium/calcium exchanger protein	NCKX6 NCLX SLC24A6 SLC8B1	view
Q8NFF2	Sodium/potassium/calcium exchanger 4	NCKX4 SLC24A4	view
Q9HC58	Sodium/potassium/calcium exchanger 3	NCKX3 SLC24A3	view
Q9UI40	Sodium/potassium/calcium exchanger 2	NCKX2 SLC24A2	view
Q9UPR5	Sodium/calcium exchanger 2	KIAA1087 NCX2 SLC8A2	view

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