RHO GTPases Activate Formins

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Profilin:G-actinRAC1:GTP:FMNL1:Profilin:G-actinRAC1:GTP:FMNL1SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actinPiH2OFMNL1SRGAP2RAC1:GDPFMNL2CDC42:GTP:FMNL2CDC42:GTPRHOC:GTP:FMNL3:G-actinRHOC:GTP:FMNL3DIAPH1RHOA:GTP:DIAPH1RHOA:GTPMALMKL1ITGB1 geneITGB1CDC42:GTPKinetochore:CDC42:GTP:DIAPH2-2DIAPH2-2KinetochoreMicrotubuleMicrotubule-bound kinetochorepp-DVLppDVL:DAAM1DAAM1RHOA:GTP:Mg2+ppDVL:DAAM1:RHOA:GTPRAC1:GTPG-actinPFNCDC42:GTP:FMNL1CDC42:FMNL2:Profilin:G-actinRHOC:GTP:FMNL2RHOC:GTPFMNL3Profilin:G-actin:MKL1EVLRHOA:GTP:DIAPH1:EVL:Profilin:G-actinSRF:MKL1SRFSRF:MKL1:SCAISCAISRF:MKL1:ITGB1 GeneDIAPH1,DIAPH3RHOB:GTP:DIAPH1,DIAPH3RHOB:GTPRHOD:GTPRHOD:GTP:DIAPH2-3DIAPH2CRHOD:GTP:DIAPH2:SRC-1SRC1Kinetochore:CDC42:GTP:p-S196-DIAPH2-2ADPATP
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 7, 2025