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Processing of Intronless Pre-mRNAs

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-77595

PubChem

R-HSA-77595

Description

The 3' ends of eukaryotic mRNAs are generated by posttranscriptional processing of an extended primary transcript. For almost all RNAs, 3' processing consists of two steps: The mRNA is first cleaved at a particular phosphodiester bond downstream of the coding sequence. The upstream fragment then receives a poly(A) tail of approximately 250 adenylate residues whereas the downstream fragment is degraded. The two partial reactions are coupled so that reaction intermediates are usually undetectable. While 3' processing can be studied as an isolated event in vitro, it appears to be connected to transcription, splicing and transcription termination in vivo.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 15 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O94913	Pre-mRNA cleavage complex 2 protein Pcf11	KIAA0824 PCF11	view
O95639	Cleavage and polyadenylation specificity factor subunit 4	CPSF30 CPSF4 NAR NEB1	view
P33240	Cleavage stimulation factor subunit 2	CSTF2	view
P51003	Poly(A) polymerase alpha	PAP PAPOLA	view
Q05048	Cleavage stimulation factor subunit 1	CSTF1	view
Q09161	Nuclear cap-binding protein subunit 1	CBP80 NCBP NCBP1	view
Q10570	Cleavage and polyadenylation specificity factor subunit 1	CPSF1 CPSF160	view
Q12996	Cleavage stimulation factor subunit 3	CSTF3	view
Q6UN15	Pre-mRNA 3'-end-processing factor FIP1	FIP1 FIP1L1 RHE	view
Q86U42	Polyadenylate-binding protein 2	PAB2 PABP2 PABPN1	view

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