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Butyrophilin (BTN) family interactions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8851680

PubChem

R-HSA-8851680

Description

Butyrophilins (BTNs) and butyrophilin like (BTNL) molecules are regulators of immune responses that belong to the immunoglobulin (Ig) superfamily of transmembrane proteins. They are structurally related to the B7 family of co-stimulatory molecules and have similar immunomodulatory functions (Afrache et al. 2012, Arnett & Viney 2014). BTNs are implicated in T cell development, activation and inhibition, as well as in the modulation of the interactions of T cells with antigen presenting cells and epithelial cells. Certain BTNsare genetically associated with autoimmune and inflammatory diseases (Abeler Domer et al. 2014).
The human butyrophilin family includes seven members that are subdivided into three subfamilies: BTN1, BTN2 and BTN3. The BTN1 subfamily contains only the prototypic single copy BTN1A1 gene, whereas the BTN2 and BTN3 subfamilies each contain three genes BTN2A1, BTN2A2 and BTN2A3, and BTN3A1, BTN3A2 and BTN3A3, respectively (note that BTN2A3 is a pseudogene). BTN1A1 has a crucial function in the secretion of lipids into milk (Ogg et al. 2004) and collectively, BTN2 and BTN3 proteins are cell surface transmembrane glycoproteins, that act as regulators of immune responses. BTNL proteins share considerable homology to the BTN family members. The human genome contains four BTNL genes: BTNL2, 3, 8 and 9 (Abeler Domer et al. 2014).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00478	Butyrophilin subfamily 3 member A3	BTF3 BTN3A3	view
O00481	Butyrophilin subfamily 3 member A1	BTF5 BTN3A1	view
O60437	Periplakin	KIAA0568 PPL	view
P78410	Butyrophilin subfamily 3 member A2	BT3.2 BTF3 BTF4 BTN3A2	view
Q13410	Butyrophilin subfamily 1 member A1	BTN BTN1A1	view
Q6UX41	Butyrophilin-like protein 8	BTNL8 UNQ702/PRO1347	view
Q6UXG8	Butyrophilin-like protein 9	BTNL9 UNQ1900/PRO4346	view
Q7KYR7	Butyrophilin subfamily 2 member A1	BT2.1 BTF1 BTN2A1	view
Q8WVV5	Butyrophilin subfamily 2 member A2	BT2.2 BTF2 BTN2A2	view
Q9NNX6	CD209 antigen	CD209 CLEC4L	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_001382	Q9NNX6	CD209 antigen	view

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