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RUNX3 regulates NOTCH signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-8941856

PubChem

R-HSA-8941856

Description

RUNX3 negatively regulates NOTCH signaling, which contributes to the tumor suppressor role of RUNX3 in hepatocellular carcinoma. RUNX3 binds the promoter of the JAG1 gene, encoding NOTCH ligand JAG1 and inhibits its transcription (Nishina et al. 2011). In addition, RUNX3 also binds to the NOTCH1 coactivator complex at the promoter of HES1, a NOTCH target gene, and inhibits HES1 transcription (Gao et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P46531	Neurogenic locus notch homolog protein 1	NOTCH1 TAN1	view
P78504	Protein jagged-1	JAG1 JAGL1	view
Q06330	Recombining binding protein suppressor of hairless	IGKJRB IGKJRB1 RBPJ RBPJK RBPSUH	view
Q09472	Histone acetyltransferase p300	EP300 P300	view
Q13495	Mastermind-like domain-containing protein 1	CG1 CXorf6 MAMLD1	view
Q13573	SNW domain-containing protein 1	SKIIP SKIP SNW1	view
Q13761	Runt-related transcription factor 3	AML2 CBFA3 PEBP2A3 RUNX3	view
Q14469	Transcription factor HES-1	BHLHB39 HES1 HL HRY	view
Q8IZL2	Mastermind-like protein 2	KIAA1819 MAML2	view
Q92585	Mastermind-like protein 1	KIAA0200 MAML1	view

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