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RHOQ GTPase cycle

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9013406

PubChem

R-HSA-9013406

Description

This pathway catalogues RHOQ (also known as TC10) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOQ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOQ. Two GDIs, ARHGDIA (also known as Rho-GDI alpha) (Michaelson et al. 2001; Murphy et al. 2001) and ARHGDIB (also known as D4-GDI) (Zhang et al. 2009), were specifically shown not to interact with RHOQ. RHOQ, together with RHOJ (TCL), belongs to the CDC42 subfamily of RHO GTPases, with the three family members sharing 65-85% of homology (Murphy et al. 1999, Vignal et al. 2000, Donnelly et al. 2014; Shi et al. 2016). RHOQ is highly activated on exocytosing vesicles and recycling endosomes. RHOQ GTPase activity is necessary for fusion of vesicles with the plasma membrane (Kawase et al. 2006, Donnelly et al. 2014). RHOQ is required for insulin-stimulated glucose uptake (Kanzaki and Pessin 2003; Saltiel and Pessin 2003) and is involved in insulin signaling in adipocytes (Satoh 2014). While some studies reported RHOQ involvement in neurite outgrowth (Abe et al. 2003, Gonzalez‐Billault et al. 2012) and regulation of membrane addition during axon formation (Dupraz et al. 2009, Gonzalez‐Billault et al. 2012), other studies failed to identify RHOQ as a regulator of neurite outgrowth (Murphy et al. 1999, Murphy et al. 2001).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 43 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A7KAX9	Rho GTPase-activating protein 32	ARHGAP32 GRIT KIAA0712 RICS	view
O00161	Synaptosomal-associated protein 23	SNAP23	view
O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2	WWP2	view
O00401	Actin nucleation-promoting factor WASL	WASL	view
O14559	Rho GTPase-activating protein 33	ARHGAP33 SNX26 TCGAP	view
O60890	Oligophrenin-1	OPHN1	view
O75044	SLIT-ROBO Rho GTPase-activating protein 2	ARHGAP34 FNBP2 KIAA0456 SRGAP2 SRGAP2A	view
O96013	Serine/threonine-protein kinase PAK 4	KIAA1142 PAK4	view
P02786	Transferrin receptor protein 1	TFRC hCG_22086	view
P13569	Cystic fibrosis transmembrane conductance regulator	ABCC7 CFTR	view

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