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RHOG GTPase cycle

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9013408

PubChem

R-HSA-9013408

Description

This pathway catalogues RHOG guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), GDP dissociation inhibitors (GDIs) and RHOG effectors. RHOG is a RAC-related RHO GTPase, ~70% identical to RAC1 (Vincent et al. 1992, de Curtis 2008). RHOG is broadly expressed in different tissue types. It regulates the cytoskeleton, acting either upstream of or in parallel to RAC1. RHOG regulates cell polarity, adhesion, migration and invasion, contributing to the formation of lamellipodia and invadopodia (Gauthier-Rouvière et al. 1998, Al-Koussa et al. 2020). The ortholog of RHOG is required for neuronal development in C. elegans (de Curtis 2008). RHOG is involved in VEGF signaling and angiogenesis (El Baba et al. 2020). RHOG cooperates with RAC1 and CDC42 in malignant cell transformation (Roux et al. 1997) and may contribute to invasiveness of cancer cells (Al-Koussa et al. 2020).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 50 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A7KAX9	Rho GTPase-activating protein 32	ARHGAP32 GRIT KIAA0712 RICS	view
O15063	Granule associated Rac and RHOG effector protein 1	GARRE1 KIAA0355	view
O15173	Membrane-associated progesterone receptor component 2	DG6 PGRMC2 PMBP	view
O60229	Kalirin	DUET DUO HAPIP KALRN TRAD	view
O60890	Oligophrenin-1	OPHN1	view
O75489	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	view
O75962	Triple functional domain protein	TRIO	view
O95210	Starch-binding domain-containing protein 1	GENX-3414 STBD1	view
O95292	Vesicle-associated membrane protein-associated protein B/C	UNQ484/PRO983 VAPB	view
O96013	Serine/threonine-protein kinase PAK 4	KIAA1142 PAK4	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_002053	P49257	Protein ERGIC-53	view
GL_002768	O95210	Starch-binding domain-containing protein 1	view

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