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Activated NTRK2 signals through PLCG1

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9026527

PubChem

R-HSA-9026527

Description

Activation of the neurotrophin receptor NTRK2 (TRKB) by BDNF or NTF4 triggers downstream PLCgamma (PLCG1) signaling, resulting in formation of secondary messengers DAG and IP3 (Eide et al. 1996, Minichiello et al. 1998, McCarthy and Feinstein 1999, Yuen and Mobley 1999, Minichiello et al. 2002, Yamada et al. 2002).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P19174	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1	PLC1 PLCG1	view
P23560	Neurotrophic factor BDNF precursor form	BDNF	view
P34130	Neurotrophin-4	NTF4 NTF5	view
Q16620	BDNF/NT-3 growth factors receptor	NTRK2 TRKB	view

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