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Negative regulators of RIG-I/MDA5 signaling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-936440

PubChem

R-HSA-936440

Description

As with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune diseases. RIG-I-mediated production of IFN can, in turn, increase the transcription of RIG-I itself, thus setting into motion an IFN amplification loop, which if left unchecked, could become deleterious to the host. This module mainly focuses on the endogenous negative regulation of the RIG-I-like receptor (RLR) family proteins RIG-I (DDX58) and MDA5 (IFIH1).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 13 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O94817	Ubiquitin-like protein ATG12	APG12 APG12L ATG12	view
O95786	Antiviral innate immune response receptor RIG-I	DDX58 RIGI	view
P21580	Tumor necrosis factor alpha-induced protein 3	OTUD7C TNFAIP3	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view
Q15366	Poly(rC)-binding protein 2	PCBP2	view
Q7Z434	Mitochondrial antiviral-signaling protein	IPS1 KIAA1271 MAVS VISA	view
Q86UT6	NLR family member X1	NLRX1 NOD5 NOD9	view
Q86VP1	Tax1-binding protein 1	PRO0105 T6BP TAX1BP1	view
Q86WI3	Protein NLRC5	NLRC5 NOD27 NOD4	view

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