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Regulation of FOXO transcriptional activity by acetylation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9617629

PubChem

R-HSA-9617629

Description

Oxidative stress induces acetylation of FOXO transcription factors, which changes the preference of FOXO transcription factors for target DNA sequences. Histone deacetylases SIRT1 and SIRT3 deacetylate FOXO transcription factors (Brunet et al. 2004, Daitoku et al. 2004, Motta et al. 2004, Dansen et al. 2009, Kim et al. 2010, Tseng et al. 2013, reviewed by Hisahara et al. 2005).
Acetylation can also regulate FOXO localization, overriding phosphorylation (Frescas et al. 2005, Bertaggia et al. 2012).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 7** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O43524	Forkhead box protein O3	FKHRL1 FOXO3 FOXO3A	view
P98177	Forkhead box protein O4	AFX AFX1 FOXO4 MLLT7	view
Q09472	Histone acetyltransferase p300	EP300 P300	view
Q12778	Forkhead box protein O1	FKHR FOXO1 FOXO1A	view
Q92793	CREB-binding protein	CBP CREBBP	view
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	SIR2L1 SIRT1	view
Q9NTG7	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	SIR2L3 SIRT3	view

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