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MIRAGE
Purinergic signaling in leishmaniasis infection

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Interleukin-1 familyInterleukin-1 familyC3AR1C3AR1:C3aC3aATPATPP2RX4,7ATP:P2RX4,7NTPH+H2OPiNDPAMP,GMP,CMP,UMPADP,GDP,CDP,UDPNMNNRNAMATP:P2X4,7 trimerHSP90AB1SUGT1:HSP90SGT1NLRP3NLRP3:SUGT1:HSP90TXNThioredoxin:TXNIPTXNIPROSADFOxidized thioredoxin:TXNIPNLRP3 geneTXNIP:NLRP3NLRP3 elicitor small moleculesNLRP3 elicitor small molecules:NLRP3NLRP3 elicitors:NLRP3 oligomerNLRP3 elicitors:NLRP3 oligomer:ASCASCNLRP3 elicitors:NLRP3 oligomer:ASC:Procaspase-1CASP1Pyrin trimerPSTPIP1 trimer:Pyrin trimerPSTPIP1 trimerPyrin trimer:ASCCASP1CASP1CASP1CASP1Caspase-1 p10/p20 dimerCaspase-1 tetramerInterleukin-1 family propeptidesInterleukin-1 family N-terminal propeptides
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying entries 11 - 17 of 17 in total
UniProt ID Protein Name Gene Symbol Pathway Viewer
P57764 Gasdermin-D
  • DFNA5L
  • GSDMD
  • GSDMDC1
 view
Q00653 Nuclear factor NF-kappa-B p100 subunit
  • LYT10
  • NFKB2
 view
Q04206 Transcription factor p65
  • NFKB3
  • RELA
 view
Q16581 C3a anaphylatoxin chemotactic receptor
  • AZ3B
  • C3AR1
  • C3R1
  • HNFAG09
 view
Q99571 P2X purinoceptor 4
  • P2RX4
 view
Q99572 P2X purinoceptor 7
  • P2RX7
 view
Q9Y2Z0 Protein SGT1 homolog
  • SUGT1
 view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025