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Sealing of the nuclear envelope (NE) by ESCRT-III

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9668328

PubChem

R-HSA-9668328

Description

During telophase, the double membrane of the reforming NE, which is derived from fenestrated sheets and tubules of the mitotic ER, is sealed to reestablish the nucleocytoplasmic permeability barrier (reviewed by Otsuka and Ellenberg 2018). Some of the holes in the reforming nuclear envelope close around forming nuclear pore complexes (NPCs) (reviewed by Otsuka and Ellenberg 2018). Other fenestrations are sealed by the formation of filamentous ESCRT-III assemblies and their disassembly by the AAA+ ATPase VPS4 (VPS4A/VPS4B) (reviewed by Schoneberg et al. 2017). The ESCRT-III/VPS4 machinery has a general role in “reverse topology” membrane scission (i.e., involving the fusion of cytoplasmic membrane surfaces (reviewed by Schoneberg et al. 2017). In concert with these events, microtubules connected to the kinetochore and to other chromosomal regions are severed (reviewed by Schoneberg et al. 2017).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 19 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A6NNZ2	Tubulin beta 8B	TUBB8B	view
P04350	Tubulin beta-4A chain	TUBB4 TUBB4A TUBB5	view
P68363	Tubulin alpha-1B chain	TUBA1B	view
P68366	Tubulin alpha-4A chain	TUBA1 TUBA4A	view
P68371	Tubulin beta-4B chain	TUBB2C TUBB4B	view
Q13509	Tubulin beta-3 chain	TUBB3 TUBB4	view
Q13885	Tubulin beta-2A chain	TUBB2 TUBB2A	view
Q5T0F9	Coiled-coil and C2 domain-containing protein 1B	CC2D1B KIAA1836 LGD1	view
Q71U36	Tubulin alpha-1A chain	TUBA1A TUBA3	view
Q8NC56	LEM domain-containing protein 2	LEMD2	view

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