Nuclear events stimulated by ALK signaling in cancer

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
STAT5A geneMECP2:STAT5A geneMECP2STAT5ANPM1(1-117)-p-7Y ALK(1058-1620) fusion dimerNPM1-p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:ZC3HC1CUL1:RBX1:SKP1:ZC3HC1JUNB geneJUNB mRNAGZMB GeneGZMB gene:JUNB dimerJUNBPRF1 genePRF1CEBPB geneLAPICOS geneICOS dimerTWIST1 geneTWIST1p-Y705,S727-STAT3 dimerpY705, S727-STAT3 dimer:IRF4 geneIRF4 geneB23NPM1-ALK;NPM1:FOXM1WINIL10RA geneIL10RANOTCH1 geneNOTCH1 mRNAPTPN6 geneSHP1MIR21 genemiR21 RISCDNMT1 mRNADNMT1DNMT1 geneRB1phospho-RbNPM1(1-117)-p-7Y ALK(1058-1620) fusion dimerADPATPNPM1p-7Y ALK fusion dimer:CUL1:RBX1:SKP1:p-S354 ZC3HC1HLPBCL2A1 geneBCL2A1ICOS gene:p-STAT3IRF4CCNB1 GeneCCNB1p-Y705,S727 -STAT3 dimer: NOTCH genepY705, S727 STAT dimer:DNMT1:HDAC1:PTPN6 geneHDAC1AcK685- p-Y705,S727-STAT3 dimerMIR21 gene:AcK685-pY705,p-S727 STAT3 dimermiR-21 RISC:DNMT1 mRNAAcK685-p-Y705, S727-STAT3 dimer:DNMT1 geneZAP70 geneZAP70
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: February 17, 2025