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MIRAGE
IFNG signaling activates MAPKs

Summary
Species
Homo sapiens
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
RAF1IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:RAF1IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2ATPADPIFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2:p-Y-RAF1MAPKsp-ERK dimer
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
Displaying all 5 entries
UniProt ID Protein Name Gene Symbol Pathway Viewer
P01579 Interferon gamma
  • IFNG
 view
P04049 RAF proto-oncogene serine/threonine-protein kinase
  • RAF
  • RAF1
 view
P15260 Interferon gamma receptor 1
  • IFNGR1
 view
P23458 Tyrosine-protein kinase JAK1
  • JAK1
  • JAK1A
  • JAK1B
 view
P38484 Interferon gamma receptor 2
  • IFNGR2
  • IFNGT1
 view
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025