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Aspirin ADME

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9749641

PubChem

R-HSA-9749641

Description

In water aspirin (acetylsalicylic acid, ASA) dissolves, dissociating into the acetylsalicylate ion (ASA-). ASA- is an anti-clotting agent and nonsteroidal anti-inflammatory drug (NSAID); the therapeutic effects are mediated through its interaction with PTGS enzymes. On a molar basis ASA- (a) is more potent as an analgesic/anti-inflammatory agent, (b) has greater gastric ulcerogenic activity, and (c) is much more effective as an inhibitor of prostaglandin biosynthesis and platelet aggregation than salicylate (ST) (Flower 1974; Mills et al, 1974; Rainsford 1975; Rainsford 1977).
Acetylsalicylic acid is only slightly soluble in conditions being found in the stomach mucosa, mostly because of unavailability of sufficient amount of solvent. The absorption, as well as the absorbing area, increases in the small intestine. Further increased absorption is achieved by dissolving tablets before ingestion or usage of ASA salts (Dressman et al, 2012). Practically 100% of therapeutic aspirin doses are taken up, mostly by intestinal mucosal cells (Artursson & Karlsson, 1991; Yee 1997).
Only a few percent of ASA- remain unchanged, the rest is hydrolyzed to salicylate (ST). The major route of ST catabolism is conjugation with glycine to form salicyluric acid. This accounts for 20–65% of the products. Conjugation to glucuronides (ester and ether) removes up to 42% of ST. Finally, a minor part also gets hydroxylated by cytochromes (Hutt et al, 1986).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 28 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00748	Cocaine esterase	CES2 ICE	view
O15438	ATP-binding cassette sub-family C member 3	ABCC3 CMOAT2 MLP2 MRP3	view
O60656	UDP-glucuronosyltransferase 1A9	GNT1 UGT1 UGT1A9	view
O75310	UDP-glucuronosyltransferase 2B11	UGT2B11	view
O75795	UDP-glucuronosyltransferase 2B17	UGT2B17	view
P02768	Albumin	ALB GIG20 GIG42 PRO0903 PRO1708 PRO2044 PRO2619 PRO2675 UNQ696/PRO1341	view
P06133	UDP-glucuronosyltransferase 2B4	UGT2B11 UGT2B4	view
P06276	Cholinesterase	BCHE CHE1	view
P0C7M7	Acyl-coenzyme A synthetase ACSM4, mitochondrial	ACSM4	view
P0DTE4	UDP-glucuronosyltransferase 2A1	UGT2A1	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_004606	P35613	Basigin	view

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