GlyCosmos Portal

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Dengue Virus-Host Interactions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9918481

PubChem

R-HSA-9918481

Description

After translation and post-translational modification in the cytosol, endoplasmic reticulum, and ERGIC (ER-Golgi intermediate compartment), Dengue virus (DENV) proteins localize to several other compartments interacting with host proteins. Large amounts of NS1 get secreted in the bloodstream and bind to and enter other cells, modulating innate and adaptive immune processes before those cells get infected. Other proteins affecting immune responses in infected cells are C, prM, the NS2B3 protease complex, and NS5. C and NS5 localize to the nucleus, where they also modulate apoptosis. Extracellular NS1 and nuclear NS5 contribute to Dengue hemorrhagic fever (DHF) by binding cell-junction proteins. The NS3 protein can be imported into mitochondria. For a general review, see Zeidler et al., 2017. Recent proteomic results include Karyala et al., 2016; Dey & Mukhopadhyay, 2017; Shah et al., 2018; reviewed in Carlin & Shresta, 2019.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of **161** in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00206	Toll-like receptor 4	TLR4	view
O00468	Agrin	AGRIN AGRN	view
O15042	U2 snRNP-associated SURP motif-containing protein	KIAA0332 SR140 U2SURP	view
O15514	DNA-directed RNA polymerase II subunit RPB4	POLR2D	view
O43143	ATP-dependent RNA helicase DHX15	DBP1 DDX15 DHX15	view
O43390	Heterogeneous nuclear ribonucleoprotein R	HNRNPR HNRPR	view
O43660	Pleiotropic regulator 1	PLRG1	view
O60231	Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16	DBP2 DDX16 DHX16 KIAA0577 PRP2	view
O60306	RNA helicase aquarius	AQR KIAA0560	view
O60814	Histone H2B type 1-K	H2BC12 H2BFT HIRIP1 HIST1H2BK	view

Displaying **all 2** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005327	O00468	Agrin	view
GL_005334	P98160	Basement membrane-specific heparan sulfate proteoglycan core protein	view

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