Degradation of beta-catenin by the destruction complex

Summary
Species
Mus musculus
Reactome
PubChem
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
ApcZRANB1:K63polyUb-APCZRANB1Amer1AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexQ8BK63PP2AGSK3BAxin1p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexATPADPCtnnb1CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexp-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complexp-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complexRBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complexBTRC:CUL1:RBX1:SKP1ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complexUbp-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex
ProteinProtein familyDNARNAComplexChemical/MoleculePhenotype/StimulusNucleusMitochondriaEndosomeGolgi apparatusLysosomeMembraneUp-regulatesDown-regulatesPhysical interactionUnknownDirectIndirectBindingHighlight
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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