GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **226 - 250** of **499** in total

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Pathway Name	Protein Name ▲	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
CS/DS degradation	Beta-hexosaminidase A Hyaluronidase Sulfatase N-terminal domain-containing protein	A0A4V0IJ66 G5ECE8 Q22492	Chnase chhy-1 hex-1 sul-3	Caenorhabditis elegans	G27025MB
HS-GAG biosynthesis	Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 GlyPicaN Heparan sulfate 2-O-sulfotransferase hst-2 Heparan-sulfate 6-O-sulfotransferase Ig-like domain-containing protein InTestinal NeureXin-like LONg Laminin G domain-containing protein Probable syndecan Sulfotransferase domain-containing protein Sulfotransferase domain-containing protein Thioredoxin domain-containing protein Titin homolog UDP-sugar transporter sqv-7	C6KRM7 G4SLH0 G5ECV3 G5EFN7 G5EGU4 O17645 O45000 P50605 Q18530 Q18779 Q22574 Q4TTA0 Q966W3 Q9TZK5	C03H12.1 CELE_T19D12.6 gpn-1 hst-1 hst-2 hst-3.1 hst-3.2 hst-6 itx-1 lon-2 rig-5 sdn-1 sqv-7 ttn-1	Caenorhabditis elegans
Detoxification of Reactive Oxygen Species	Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] Catalase Cytochrome c 2.1 Glutathione S-transferase P Glutathione peroxidase 3 Glutathione peroxidase Glutathione reductase, mitochondrial Peroxiredoxin prdx-2 Probable cytochrome c 2.2 Probable glutathione reductase 2 Probable peroxiredoxin prdx-3 Probable thioredoxin-2 Superoxide dismutase [Cu-Zn] Superoxide dismutase [Mn] 1, mitochondrial Thioredoxin domain-containing protein Thioredoxin reductase 1 Thioredoxin-1	A0A0K3AUJ9 P10299 P19974 P30635 P31161 P34697 Q09433 Q17424 Q17745 Q21824 Q23240 Q8MXT1 Q8MYL7 Q93204 Q93379 Q95003 Q9U2M7	ctl-3 cyc-2.1 cyc-2.2 gpx-3 gpx-5 gsr-1 gst-1 ndx-4 prdx-2 prdx-3 prdx-6 prx2 sdm-1 sod-1 sod-2 tag-56 trx-1 trx-2 trxr-1 trxr-2	Caenorhabditis elegans
G alpha (s) signalling events	Bursicon Dopamine receptor 2 G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Glycoprotein hormone subunit beta domain-containing protein Guanine nucleotide-binding protein G(s) subunit alpha Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Probable 3',5'-cyclic phosphodiesterase pde-1 Probable 3',5'-cyclic phosphodiesterase pde-2 Probable 3',5'-cyclic phosphodiesterase pde-3 Probable 3',5'-cyclic phosphodiesterase pde-5 Probable 3',5'-cyclic phosphodiesterase pde-6 Probable 3',5'-cyclic-AMP phosphodiesterase pde-4	A7DT38 E7EM37 G5ECT6 G5EGH0 H2KZ99 L8EC40 O18014 O18696 P17343 P30645 P54406 P91119 Q17553 Q19779 Q1ZXT2 Q20636 Q20827 Q21013 Q22000 Q22895 Q7KPV0 Q86ME6 Q8I0P7 Q9N2V9 Q9XUK8	CELE_F55D10.4 ador-1 dop-1 dop-2 dop-2L eat-11 flr-2 fshr-1 gbp-2 gnrr-4 gpb-1 gpb-2 gpb5 gpc-1 gpc-2 gplb-1 gsa-1 gtr-1 npr-14 npr-25 npr-42 pde-1 pde-2 pde-3 pde-4 pde-5 pde-6 ser-4 ser-7	Caenorhabditis elegans
Acyl chain remodelling of PC	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Lipase_GDSL domain-containing protein Lysophospholipid acyltransferase 5 Lysophospholipid acyltransferase Membrane Bound O-Acyl transferase, MBOAT PNPLA domain-containing protein Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2 lysoplasmalogenase phospholipase A2	G4RY15 G5EC53 H9G2W5 O01925 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q21552 Q22591 Q3V5J7 Q8MXR3 Q95YD2 Q9N2Z4 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 C45B2.6 CELE_M176.4 CELE_Y65B4BR.1 CELE_Y69A2AL.2 LPT-1 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 ipla-6 mboa-3 mboa-4 mboa-6	Caenorhabditis elegans
Acyl chain remodelling of PS	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Lysophospholipid acyltransferase 5 Lysophospholipid acyltransferase PH domain-containing protein Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2	G4RY15 G5EC53 O01925 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q22591 Q3V5J7 Q8MPR9 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 CELE_Y69A2AL.2 LPT-1 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 mboa-3 mboa-6 obr-3	Caenorhabditis elegans
Acyl chain remodelling of PI	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Lysophospholipid acyltransferase 7 Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2	G4RY15 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q19468 Q22591 Q3V5J7 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 CELE_Y69A2AL.2 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 lpiat mboa-7 tag-289	Caenorhabditis elegans
Acyl chain remodelling of PG	C-type lectin domain-containing protein 161 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Phospholipase A(2) Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipid/glycerol acyltransferase domain-containing protein Probable cardiolipin synthase (CMP-forming)	A0A486WXW2 G4RY15 O01916 O16654 P34472 P91429 Q17450 Q17452 Q17790 Q18339 Q22591 Q3V5J7 Q9TZ75 Q9XUL6 Q9XUL7 Q9XVE1	C03H5.4 C07E3.9 C31H1.5 CELE_Y69A2AL.2 acl-14 clec-148 clec-161 clec-178 clec-48 clec-49 clec-50 clec-51 clec-52 clec-53 clec-89 crls-1	Caenorhabditis elegans
Dectin-2 family	C-type lectin domain-containing protein 87 C-type lectin domain-containing protein 88 C-type lectin domain-containing protein 91 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein Calcineurin-interacting protein 2 EGF-like domain-containing protein EGF-like domain-containing protein	D3KFV8 H2KZ07 O18076 O45275 P91214 Q18821 Q1ZXU1 Q20665 Q21146 Q86NG3 Q94417 Q9N4W5 Q9U2D6 Q9XUF9 Q9XVS3 Q9XVT9 Q9XWC4 Q9XX56	C49C3.4 CELE_F52E1.2 CELE_Y38H6C.8 clec-149 clec-196 clec-199 clec-202 clec-204 clec-224 clec-266 clec-45 clec-47 clec-86 clec-87 clec-88 clec-91 cnp-2 cpg-5 cpg-6 paml-1	Caenorhabditis elegans
Asparagine N-linked glycosylation	C-type lectin domain-containing protein 87 C-type lectin domain-containing protein 88 C-type lectin domain-containing protein 91 C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein C-type lectin domain-containing protein	D3KFV8 H2KZ07 O18076 O45275 P91214 Q18821 Q1ZXU1 Q20665 Q21146 Q86NG3 Q94417 Q9N4W5 Q9XVS3 Q9XVT9 Q9XX56	CELE_F52E1.2 CELE_Y38H6C.8 clec-149 clec-196 clec-199 clec-202 clec-204 clec-224 clec-266 clec-45 clec-47 clec-86 clec-87 clec-88 clec-91 cpg-5 cpg-6	Caenorhabditis elegans
Heme signaling	C-type lectin domain-containing protein C-type lectin domain-containing protein Protein vem-1 Proton-coupled folate transporter SoLute Carrier family Related SoLute Carrier family Related Solute carrier family 46 member 3	A0A061AD52 G5EFM5 H2KZC0 Q20236 Q7YZW5 Q9UAZ6 Q9XWL3	C25G4.17 clec-185 slc-46A slc-46a slcr-46.1 slcr-46.2 slcr-46.3 vem-1	Caenorhabditis elegans
MET activates RAP1 and RAC1	C2 DOCK-type domain-containing protein Cell death abnormality protein 2 Kringle domain-containing protein Protein kinase domain-containing protein Rap guanine nucleotide exchange factor 1 Ras-related protein Rap-1 Ras-related protein ced-10 Sex muscle abnormal protein 5 Tyrosine-protein kinase receptor svh-2	H2KZU7 H2KZX7 P29355 P91823 Q03206 Q18246 Q20487 Q9NHC3 Q9XVQ7	CELE_F11E6.8 CELE_F46H5.4 CELE_T22A3.6 CELE_Y34B4A.4 ced-10 ced-2 rac-1 rap-1 sem-5 svh-2	Caenorhabditis elegans
RNA Polymerase II Transcription Termination	C2H2-type domain-containing protein Chromatin target of PRMT1 protein C-terminal domain-containing protein Cleavage and polyadenylation specificity factor subunit 3 Cleavage and polyadenylation specificity factor subunit 4 Cleavage and polyadenylation specificity factor subunit 5 Cleavage stimulation factor 50 kDa subunit DUF3453 domain-containing protein Death domain-containing protein Histone RNA hairpin-binding protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 PWI domain-containing protein Poly(A) polymerase Polyadenylation and cleavage factor homolog 11 Pre-mRNA 3'-end-processing factor FIP1 Pre-mRNA-splicing factor SLU7 Probable cleavage and polyadenylation specificity factor subunit 1 Probable cleavage and polyadenylation specificity factor subunit 2 Probable pre-mRNA-splicing factor ATP-dependent RNA helicase mog-1 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein-associated protein B Probable splicing factor, arginine/serine-rich 2 Probable splicing factor, arginine/serine-rich 3 Probable splicing factor, arginine/serine-rich 4 Probable splicing factor, arginine/serine-rich 6 Probable splicing factor, arginine/serine-rich 7 Protein CASC3 Protein clpf-1 Protein mago nashi homolog RNA helicase RNA-binding protein rnp-4 RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein RRM domain-containing protein SAP domain-containing protein Sm domain-containing protein Sm domain-containing protein Small nuclear ribonucleoprotein Sm D3 Spliceosome RNA helicase DDX39B homolog Splicing factor U2AF 35 kDa subunit Splicing factor U2AF 65 kDa subunit Suppressor of forked domain-containing protein THO complex subunit 2 THO complex subunit 5 THO complex subunit 7 homolog UPF3 domain-containing protein WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein pre-mRNA 3' end processing protein pfs-2	A0A164D3G3 C1P629 C2BR94 G5EDE4 O01159 O01763 O16929 O17403 O18219 O44729 O45577 O62185 P34498 P34659 P49029 P52874 P90978 P91867 P91918 Q09345 Q09511 Q09599 Q17348 Q18033 Q18212 Q18409 Q19864 Q19866 Q21155 Q21278 Q21559 Q21832 Q23120 Q7YTG9 Q7YWY5 Q8WQF3 Q93233 Q93594 Q93716 Q95PY8 Q9BL61 Q9GYQ8 Q9N3G0 Q9N4C2 Q9N4G9 Q9N5E3 Q9NEW6 Q9U2P3 Q9U2U0 Q9U3S3 Q9XTU6 U4PCM1 V6CKC3	C49H3.4 CELE_K07A1.15 CELE_Y53G8AR.6 CELE_Y57G11A.5 K07C5.6 RBM8 Y14 aly-3 casc-3 cbp-20 cbp-80 cdl-1 cfim-1 cfim-2 clpf-1 cpf-1 cpf-2 cpsf-1 cpsf-2 cpsf-3 cpsf-4 eif-4A3 fipp-1 hel-1 mag-1 mog-1 ncbp-1 ncbp-2 pabp-2 pap-1 pcf-11 pfs-2 prp-17 rnp-4 rnp-5 rsp-2 rsp-3 rsp-4 rsp-6 rsp-7 rsr-1 smg-4 snr-1 snr-2 snr-5 snr-6 snr-7 srp-1 srp-2 srp-4 suf-1 symk-1 thoc-1 thoc-2 thoc-3 thoc-5 thoc-7 uaf-1 uaf-2 znf-236	Caenorhabditis elegans
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	C2H2-type domain-containing protein Histone RNA hairpin-binding protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein-associated protein B Sm domain-containing protein Sm domain-containing protein Small nuclear ribonucleoprotein Sm D3	O01763 P34659 P91918 Q09599 Q17348 Q7YWY5 Q93594 Q9GYQ8 Q9N4G9 Q9XTU6 V6CKC3	C49H3.4 CELE_K07A1.15 cbp-20 cbp-80 cdl-1 ncbp-1 ncbp-2 snr-1 snr-2 snr-5 snr-6 snr-7 znf-236	Caenorhabditis elegans
SLBP independent Processing of Histone Pre-mRNAs	C2H2-type domain-containing protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein-associated protein B Sm domain-containing protein Sm domain-containing protein Small nuclear ribonucleoprotein Sm D3	O01763 P34659 P91918 Q17348 Q7YWY5 Q93594 Q9GYQ8 Q9N4G9 Q9XTU6 V6CKC3	C49H3.4 CELE_K07A1.15 cbp-20 cbp-80 ncbp-1 ncbp-2 snr-1 snr-2 snr-5 snr-6 snr-7 znf-236	Caenorhabditis elegans
DCC mediated attractive signaling	CED-5 CRAL-TRIO domain-containing protein Cell division control protein 42 homolog Homeobox protein ceh-6 Inactive tyrosine-protein kinase kin-32 NCK (Non-Catalytic region of tyrosine Kinase) adaptor protein family Netrin receptor unc-40 Ras-related protein ced-10 Tyrosine protein-kinase src-1	G5EE56 G5EEN3 G5EF96 O61528 P20268 Q03206 Q05062 Q95PX0 Q95YD4	cdc-42 ced-10 ced-5 ceh-6 kin-32 nck-1 rac-1 src-1 unc-40 unc-73	Caenorhabditis elegans
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	CED-5 Cell death abnormality protein 12 Cell death abnormality protein 2 Protein kinase domain-containing protein Protein nipi-4 Ras-like GTP-binding protein rhoA Ras-related protein ced-10 Rho-GAP domain-containing protein Tyrosine-protein kinase	A0A4V0IL59 G5EEN3 O16262 O45611 Q03206 Q22038 Q8STE5 Q9N3S5 Q9NHC3	CELE_Y47G6A.5 ced-10 ced-12 ced-2 ced-5 nipi-4 rac-1 rga-5 rho-1 rhoa trk-1	Caenorhabditis elegans
G alpha (i) signalling events	CELF35-1 Dopamine receptor 2 Dopamine receptor 3 G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 3 profile domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Guanine nucleotide-binding protein alpha-16 subunit Guanine nucleotide-binding protein alpha-4 subunit Guanine nucleotide-binding protein alpha-6 subunit Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Muscarinic acetylcholine receptor gar-3 Neuropeptide receptor 18 Probable G-protein coupled receptor C06G4.5 Probable metabotropic glutamate receptor mgl-1 RGS domain-containing protein RGS domain-containing protein Regulator of G-protein signaling 7 Regulator of G-protein signaling egl-10 Regulator of G-protein signaling rgs-10 Regulator of G-protein signaling rgs-11 Regulator of G-protein signaling rgs-1 Regulator of G-protein signaling rgs-2 Regulator of G-protein signaling rgs-3 Regulator of G-protein signaling rgs-6 Regulator of G-protein signaling rgs-7 Regulator of G-protein signaling rgs-9 SERPIN domain-containing protein SERPIN domain-containing protein Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Tetratricopeptide repeat protein 28 Tyramine receptor Ser-2 Tyramine receptor tyra-2 Tyrosine protein-kinase src-1	A0A0K3AXD3 A0A3B1DQQ4 A0A5S9MNH1 A1IMB8 A9Z1L1 E7EM37 G5ECB2 G5ECK9 G5ECT6 G5ECY2 G5ECZ3 G5EE40 G5EE56 G5EFH4 G5EGH0 H2KZ99 H2L0Q3 O01818 O02213 O17365 O17589 O18014 O45520 O45523 O45524 P17343 P34295 P34311 P49808 P49809 P54406 Q09502 Q09630 Q18287 Q18312 Q18563 Q19084 Q19651 Q19779 Q19955 Q1ZXT2 Q20636 Q20827 Q20841 Q23033 Q23376 Q6RYS9 Q7JP61 Q8MPR3 Q8WQC0 Q93743 Q9BIG5 Q9N2V6 Q9N452 Q9U7D5 Q9XVQ1	C06G4.5 C28G1.2 CELE_F15D3.4 CELE_F35H10.10 CELE_F44G3.7 CELE_F55D10.4 CELE_F57C9.6 CELE_ZK813.5 ador-1 ags-3 dop-2 dop-2L dop-3 eat-11 eat-16 egl-10 gar-3 gbb-1 gbb-2 gbp-2 gnrr-4 gpa-16 gpa-4 gpa-6 gpb-1 gpb-2 gpc-1 gpc-2 gtr-1 mgl-1 mgl-3 npr-16 npr-18 npr-23 npr-24 npr-25 npr-26 npr-28 octr-1 rgs-1 rgs-10 rgs-11 rgs-2 rgs-3 rgs-4 rgs-6 rgs-7 rgs-8.1 rgs-8.2 rgs-9 ser-2 ser-4 spn-1 src-1 srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 tyra-2	Caenorhabditis elegans
Class C/3 (Metabotropic glutamate/pheromone receptors)	CELF35-1 G-protein coupled receptors family 3 profile domain-containing protein G-protein coupled receptors family 3 profile domain-containing protein Gamma-aminobutyric acid type B receptor subunit 1 Gamma-aminobutyric acid type B receptor subunit 2 Probable metabotropic glutamate receptor mgl-1	A1IMB8 G5ECB2 G5ECZ3 G5EG10 H2L0Q3 Q09630	CELE_F35H10.10 gbb-1 gbb-2 mgl-1 mgl-2 mgl-3	Caenorhabditis elegans
G2/M DNA damage checkpoint	CHeckpoint Kinase Related	A4F324	chkr-1	Caenorhabditis elegans
G alpha (12/13) signalling events	CRAL-TRIO domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein DH domain-containing protein G Protein, Alpha subunit G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein Guanine nucleotide exchange factor Guanine nucleotide-binding protein alpha-12 subunit Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Intersectin-1 Plexin-2 Protein ECT2 Protein vav-1 Protein vav Ras-like GTP-binding protein rhoA Rho guanine nucleotide exchange factor osg-1 Rho-associated protein kinase let-502 SH2 domain-containing protein SH3 domain-containing GRB2-like protein SH3 domain-containing protein Son of sevenless homolog	A0A0K3AQN0 A0A0K3AS36 G5EBX8 G5ECK4 G5ECT6 G5EF62 G5EFE1 H2KYI7 O01847 O45657 O61528 P17343 P54406 P92199 Q19572 Q20636 Q21430 Q21653 Q22038 Q45FX5 Q965J0 Q9N4F4 Q9N5D3 Q9U364 S6EZU2 X5LV34	CELE_Y105E8A.25 cgef-1 dnbp-1 eat-11 ect-2 ephx-1 exc-5 gbp-2 gpa-12 gpa-17 gpb-1 gpb-2 gpc-1 gpc-2 itsn-1 let-341 let-502 osg-1 pix-1 plx-2 rhgf-1 rhgf-2 rho-1 rhoa ser-5 sos-1 tiam-1 uig-1 unc-73 vav-1	Caenorhabditis elegans
U12 Dependent Splicing	CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein CSD domain-containing protein DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 2 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 PSP proline-rich domain-containing protein Pre-mRNA-processing factor 6 Pre-mRNA-splicing factor 8 homolog Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable small nuclear ribonucleoprotein E Probable small nuclear ribonucleoprotein F Probable small nuclear ribonucleoprotein G Probable small nuclear ribonucleoprotein Sm D1 Probable small nuclear ribonucleoprotein Sm D2 Probable small nuclear ribonucleoprotein-associated protein B Probable splicing factor, arginine/serine-rich 2 Probable splicing factor, arginine/serine-rich 3 Probable splicing factor, arginine/serine-rich 4 Probable splicing factor, arginine/serine-rich 6 RNA helicase RNA helicase RNA polymerase Rpb4/RPC9 core domain-containing protein Small nuclear ribonucleoprotein Sm D3 Splicing factor 3B subunit 1 domain-containing protein Splicing factor 3B subunit 3 Splicing factor 3B subunit 4 Thioredoxin-like protein Tr-type G domain-containing protein Transcription initiation factor IIF subunit alpha U5 small nuclear ribonucleoprotein 200 kDa helicase WD_REPEATS_REGION domain-containing protein WD_REPEATS_REGION domain-containing protein	G5EDV3 G5EEQ8 L8E6I4 O01763 O02092 O02097 O16997 O44985 O62213 P16356 P34369 P34659 P91306 P91398 P91918 Q09442 Q09511 Q10013 Q10578 Q17348 Q17558 Q17684 Q18409 Q18786 Q19211 Q19826 Q23120 Q23463 Q8MYM8 Q93338 Q93382 Q93594 Q95QN2 Q965S0 Q9GR61 Q9GRZ2 Q9N3C9 Q9N4G9 Q9N5K2 Q9NEW6 Q9U2G0 Q9U3I0 Q9XTU6 Q9XVH6	C46F11.4 ama-1 cbp-20 cbp-80 cey-1 cey-2 cey-3 cey-4 ddx-23 dib-1 eftu-2 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 ncbp-1 ncbp-2 prp-6 prp-8 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 rsp-2 rsp-3 rsp-4 rsp-6 sap-49 sftb-1 sftb-2 snr-1 snr-2 snr-3 snr-4 snr-5 snr-6 snr-7 snrp-200 snrp-40.1 snrp-40.2 srp-1 srp-2 srp-4 teg-4	Caenorhabditis elegans
Depolymerization of the Nuclear Lamina	CTD nuclear envelope phosphatase 1 homolog Cyclin N-terminal domain-containing protein Cyclin-dependent kinase 1 G2/mitotic-specific cyclin-B1 G2/mitotic-specific cyclin-B Intermediate filament protein ifa-1 Intermediate filament protein ifa-2 Intermediate filament protein ifa-3 Intermediate filament protein ifa-4 Intermediate filament protein ifb-1 Intermediate filament protein ifb-2 Intermediate filament protein ifc-1 Intermediate filament protein ifc-2 Intermediate filament protein ifd-1 Intermediate filament protein ifd-2 Intermediate filament protein ifp-1 LNS2/PITP domain-containing protein Lamin-1 Nuclear envelope phosphatase-regulatory subunit 1 homolog Protein kinase C-like 2	O02365 O45168 O45926 P34556 P90900 P90901 P90980 Q09501 Q10653 Q19286 Q19289 Q19782 Q20432 Q21065 Q21067 Q21443 Q86DC6 Q9BLB5 Q9XXN3 Q9XXT5	cdk-1 cnep-1 cyb-1 cyb-2.1 cyb-2.2 ifa-1 ifa-2 ifa-3 ifa-4 ifb-1 ifb-2 ifc-1 ifc-2 ifd-1 ifd-2 ifp-1 kin-11 lam-1 lmn-1 lpin-1 mua-6 ncc-1 nepr-1 pkc-2 scpl-2	Caenorhabditis elegans
Collagen biosynthesis and modifying enzymes	CUB domain-containing protein Collagen alpha-1(IV) chain Collagen alpha-2(IV) chain Fe2OG dioxygenase domain-containing protein Fe2OG dioxygenase domain-containing protein Fe2OG dioxygenase domain-containing protein Fe2OG dioxygenase domain-containing protein Fibronectin type-III domain-containing protein Glycosyltransferase 25 family member Multifunctional procollagen lysine hydroxylase and glycosyltransferase Prolyl 4-hydroxylase subunit alpha-1 Prolyl 4-hydroxylase subunit alpha-2 Protein disulfide-isomerase 1 Protein disulfide-isomerase 2 Putative cuticle collagen 99 Thioredoxin domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein VWFA domain-containing protein Zinc metalloproteinase nas-39	B1V8J1 B1V8J4 G5EGA4 G5EGU7 H2FLL2 O01545 O61901 O76368 O76836 P17139 P17140 Q10576 Q17770 Q17967 Q17985 Q18048 Q18989 Q20065 Q20176 Q20679 Q21394 Q9GZF5 Q9N5F6 Q9XUP0	C14E2.4 C16E9.1 C18H7.1 C29A12.6 CELE_D2045.9 CELE_F31F7.2 CELE_K09E2.1 CELE_M04D5.1 CELE_R193.2 CELE_T19D12.4 CELE_W02G9.4 CELE_Y43F8B.19 clb-1 clb-2 cle-1 col-99 dpy-18 emb-9 let-2 let-268 nas-39 pdi-1 pdi-2 phy-1 phy-2 phy-3 phy-4	Caenorhabditis elegans
Negative regulation of NOTCH4 signaling	CUB domain-containing protein EGF-like domain-containing protein Protein lin-12 Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2	P14585 P90891 Q17941 Q21850 Q9XTG7	CELE_F55H12.3 CELE_R08E3.1 akt-1 akt-2 lin-12	Caenorhabditis elegans

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