GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **301 - 325** of **499** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▲	Organism	GlyTouCan ID
MTOR signalling	14-3-3-like protein 1 14-3-3-like protein 2 DAF-15 GTP-binding protein Rheb homolog 1 GTP-binding protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Serine/threonine-protein kinase akt-1 Serine/threonine-protein kinase akt-2 Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog	G5EGB3 O17268 P34443 P41932 P91040 Q17941 Q19425 Q20655 Q22743 Q68TI8 Q8WQG5 Q95Q95 Q9N2U6 Q9XTG7	CeTor F13H10.3 akt-1 akt-2 daf-15 ftt-1 ftt-2 let-363 lmtr-2 lmtr-3 lmtr-5 mlst-8 par-5 raga-1 ragc-1 rheb-1	Caenorhabditis elegans
mTORC1-mediated signalling	14-3-3-like protein 1 14-3-3-like protein 2 DAF-15 Eukaryotic elongation factor 2 kinase GTP-binding protein Rheb homolog 1 GTP-binding protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 MIF4G domain-containing protein Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Ribosomal protein S6 kinase beta Small ribosomal subunit protein eS6 Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog peptidylprolyl isomerase peptidylprolyl isomerase	A0A486WX07 G5EGB3 O01991 O17268 P34443 P41932 P91040 Q19425 Q20655 Q22743 Q68TI8 Q8I4E5 Q8WQG5 Q95Q95 Q9N2U6 Q9NAH6 Q9NEN6 Q9U2Q8	CeTor F13H10.3 daf-15 efk-1 fkb-2 fkb-8 ftt-1 ftt-2 ifg-1 let-363 lmtr-2 lmtr-3 lmtr-5 mlst-8 par-5 raga-1 ragc-1 rheb-1 rps-6 rsks-1	Caenorhabditis elegans
Regulation of PTEN gene transcription	DAF-15 GTP-binding protein Rheb homolog 1 GTP-binding protein Histone-lysine N-methyltransferase mes-2 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Polycomb protein mes-6 Probable histone-binding protein lin-53 Probable histone-binding protein rba-1 Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Repressor of RNA polymerase III transcription MAF1 Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog Zinc finger protein egl-43	G5EGB3 O17268 O17514 P34443 P90916 P90917 P91040 Q19425 Q22024 Q22743 Q68TI8 Q8WQG5 Q95Q95 Q9GYS1 Q9N2U6 Q9TZN2	CeTor F13H10.3 daf-15 egl-43 let-363 lin-53 lmtr-2 lmtr-3 lmtr-5 mafr-1 mes-2 mes-6 mlst-8 raga-1 ragc-1 rba-1 rba-2 rheb-1	Caenorhabditis elegans
Amino acids regulate mTORC1	DAF-15 Folliculin GTP-binding protein Rheb homolog 1 GTP-binding protein Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5 Probable V-type proton ATPase subunit F Probable V-type proton ATPase subunit G Probable V-type proton ATPase subunit H 2 Ragulator complex protein LAMTOR2 homolog Ras-related GTP-binding protein C Sodium-coupled neutral amino acid transporter 9 homolog Target of rapamycin complex subunit lst8 Target of rapamycin homolog UDENN FNIP1/2-type domain-containing protein V-type proton ATPase 116 kDa subunit a 1 V-type proton ATPase 116 kDa subunit a 2 V-type proton ATPase 116 kDa subunit a 3 V-type proton ATPase 116 kDa subunit a 4 V-type proton ATPase 16 kDa proteolipid subunit c 2 V-type proton ATPase 16 kDa proteolipid subunit c 3 V-type proton ATPase 21 kDa proteolipid subunit c'' V-type proton ATPase catalytic subunit A V-type proton ATPase subunit B 1 V-type proton ATPase subunit B 2 V-type proton ATPase subunit C V-type proton ATPase subunit D V-type proton ATPase subunit E V-type proton ATPase subunit e V-type proton ATPase subunit	B2MZD0 C0HLB3 C0HLB4 G5EDB8 G5EEK9 G5EGB3 G5EGP4 H2L0I8 O17268 P30628 P34443 P34462 P91040 P91303 Q19425 Q19626 Q20591 Q22494 Q22743 Q23680 Q68TI8 Q8WQG5 Q95Q95 Q95X44 Q95YD5 Q9N2U6 Q9N5A0 Q9XW92 Q9XXU9 S6FMZ4	CeTor F13H10.3 daf-15 flcn-1 fnip-2 fus-1 let-363 lmtr-2 lmtr-3 lmtr-5 mlst-8 raga-1 ragc-1 rdy-1 rheb-1 spe-5 unc-32 vha-10 vha-11 vha-12 vha-13 vha-14 vha-15 vha-16 vha-17 vha-2 vha-3 vha-4 vha-5 vha-6 vha-7 vha-8 vha-9	Caenorhabditis elegans
CS/DS degradation	Beta-hexosaminidase A Hyaluronidase Sulfatase N-terminal domain-containing protein	A0A4V0IJ66 G5ECE8 Q22492	Chnase chhy-1 hex-1 sul-3	Caenorhabditis elegans	G27025MB
Interconversion of polyamines	Amine oxidase domain-containing protein Thialysine N-epsilon-acetyltransferase	O17731 O76383	D2023.4 hpo-15	Caenorhabditis elegans
Metabolism of folate and pterines	10-formyltetrahydrofolate dehydrogenase Folate transporter 1 Folate-like transporter 2 Folate-like transporter 3 Methenyltetrahydrofolate cyclohydrolase Mitochondrial folate transporter/carrier Probable 5-formyltetrahydrofolate cyclo-ligase Probable methylenetetrahydrofolate reductase (NADPH) Proton-coupled folate transporter Putative dihydrofolate reductase Putative folylpolyglutamate synthase Serine hydroxymethyltransferase SoLute Carrier family Related SoLute Carrier family Related Solute carrier family 46 member 3	G5ECV9 H2KZC0 O45166 P50432 Q09509 Q17693 Q17766 Q20236 Q21084 Q21285 Q22931 Q93341 Q9UAZ6 Q9XWE6 Q9XWL3	F25B5.6 Y106G6E.4 alh-3 dao-3 dhfr-1 folt-1 folt-2 folt-3 gly-1 mel-32 mthf-1 slc-25A32 slc-25a32 slc-46A slc-46a slcr-46.1 slcr-46.2 slcr-46.3 tag-330	Caenorhabditis elegans
Synthesis of bile acids and bile salts	Cholesterol 25-hydroxylase-like protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein	A7DTF2 O01686 Q20027 Q93485	F35C8.5 obr-1 obr-2 obr-4	Caenorhabditis elegans
Glycerophospholipid biosynthesis	Uncharacterized protein F52C9.3	Q10123	F52C9.3	Caenorhabditis elegans
Switching of origins to a post-replicative state	DNA replication licensing factor MCM2 DNA replication licensing factor MCM3 DNA replication licensing factor MCM7 DNA replication licensing factor mcm-4 DNA replication licensing factor mcm-5 DNA replication licensing factor mcm-6	O16297 P34647 Q21902 Q95XQ8 Q9XVR7 Q9XXI9	MCM7 let-358 lin-6 mcm-2 mcm-3 mcm-4 mcm-5 mcm-6 mcm-7	Caenorhabditis elegans
Synthesis of glycosylphosphatidylinositol (GPI)	GPI ethanolamine phosphate transferase 1 GPI mannosyltransferase pigv-1 Mannosyltransferase N-acetylglucosaminylphosphatidylinositol deacetylase Phosphatidylinositol-glycan biosynthesis class W protein	D4YWC2 D6RYD7 G4SNP0 G5EDN2 O02164	PIG-B hpo-20 pigb-1 pigl-1 pign-1 pigv-1 pigw-1	Caenorhabditis elegans
FGFR2 alternative splicing	DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription factor IIF subunit 2 Heterogeneous nuclear ribonucleoprotein A1 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Putative RNA-binding protein PTB-1a Putative RNA-binding protein R05D3.8 RNA polymerase Rpb4/RPC9 core domain-containing protein RRM domain-containing protein Transcription initiation factor IIF subunit alpha	O01763 O02092 P16356 P34541 Q10578 Q17558 Q17684 Q18999 Q19826 Q22037 Q4W5P0 Q8MYM8 Q93338 Q93594 Q965S0 Q9GR61 Q9N3C9 Q9N5K2 Q9U3I0 Q9XVH6	R05D3.8 ama-1 cbp-20 cbp-80 gtf-2F1 gtf-2F2 gtf-2f1 gtf-2f2 hrp-1 ncbp-1 ncbp-2 ptb-1 rbp-1 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 sqd-1	Caenorhabditis elegans
Nicotinamide salvaging	ATP-dependent (S)-NAD(P)H-hydrate dehydratase NAD(P)H-hydrate epimerase NAD-capped RNA hydrolase ndx-9 Nicotinamide N-methyltransferase Nicotinate phosphoribosyltransferase Organic cation transporter 1 Sodium-dependent multivitamin transporter	P32740 P34254 Q19427 Q23616 Q95XX1 Q9U539 Q9XW15	R107.2 Y18D10A.3 anmt-1 ndx-9 nprt-1 oct-1 slc-5A12	Caenorhabditis elegans
Phase 2 - plateau phase	Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 G5EBI8 G5EDT2 O01661 P34374 Q8MQA1	STG-1 ccb-1 ccb-2 egl-19 stg-1 stg-2 unc-36 unc-72	Caenorhabditis elegans
Phase 0 - rapid depolarisation	Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent L-type calcium channel subunit alpha Voltage-dependent calcium channel unc-36	A0A078BQJ0 G5EBI8 G5EDT2 O01661 P34374 Q8MQA1	STG-1 ccb-1 ccb-2 egl-19 stg-1 stg-2 unc-36 unc-72	Caenorhabditis elegans
Presynaptic depolarization and calcium channel opening	EF-hand domain-containing protein Guanylate kinase/L-type calcium channel beta subunit domain-containing protein SH3 domain-containing protein STarGazin (Mammalian calcium channel) homolog STarGazin (Mammalian calcium channel) homolog Voltage-dependent calcium channel unc-36	A0A078BQJ0 A0A3B1E663 G5EBI8 G5EDT2 O01661 P34374	STG-1 ccb-1 ccb-2 stg-1 stg-2 unc-2 unc-36 unc-72	Caenorhabditis elegans
RNA Polymerase II Transcription Initiation	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 HTH TFE/IIEalpha-type domain-containing protein PHD-type domain-containing protein Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein FUS TAFII28-like protein domain-containing protein TAFII55 protein conserved region domain-containing protein TAFII55 protein conserved region domain-containing protein TATA-box-binding protein Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9	E9P861 G5EF68 G5EFV5 G5EG47 G5EG49 G5EGM3 K8F7X5 O02092 O16991 O17245 O44499 O44625 O45784 O61707 P16356 P32085 P34567 Q09645 Q10578 Q17558 Q17684 Q17957 Q18265 Q19826 Q20361 Q20788 Q8MYM8 Q93338 Q95PZ4 Q95ZS0 Q965S0 Q9GR61 Q9GZI6 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9NEW8 Q9NEX2 Q9TYN3 Q9U226 Q9U3I0 Q9XVH6	TFIIE-alpha TFIIE-beta ama-1 cdk-7 fust-1 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 mnat-1 pqn-51 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 taf-1 taf-10 taf-11 taf-11.3 taf-12 taf-13 taf-2 taf-3 taf-4 taf-5 taf-6.1 taf-7.1 taf-7.2 taf-9 tbp tbp-1 ttb-1 xpb-1 xpd-1	Caenorhabditis elegans
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 HTH TFE/IIEalpha-type domain-containing protein PHD-type domain-containing protein Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein FUS TAFII28-like protein domain-containing protein TAFII55 protein conserved region domain-containing protein TAFII55 protein conserved region domain-containing protein TATA-box-binding protein Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9	E9P861 G5EF68 G5EFV5 G5EG47 G5EG49 G5EGM3 K8F7X5 O02092 O16991 O17245 O44499 O44625 O45784 O61707 P16356 P32085 P34567 Q09645 Q10578 Q17558 Q17684 Q17957 Q18265 Q19826 Q20361 Q20788 Q8MYM8 Q93338 Q95PZ4 Q95ZS0 Q965S0 Q9GR61 Q9GZI6 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9NEW8 Q9NEX2 Q9TYN3 Q9U226 Q9U3I0 Q9XVH6	TFIIE-alpha TFIIE-beta ama-1 cdk-7 fust-1 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 mnat-1 pqn-51 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 taf-1 taf-10 taf-11 taf-11.3 taf-12 taf-13 taf-2 taf-3 taf-4 taf-5 taf-6.1 taf-7.1 taf-7.2 taf-9 tbp tbp-1 ttb-1 xpb-1 xpd-1	Caenorhabditis elegans
RNA Polymerase II Transcription Initiation And Promoter Clearance	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 HTH TFE/IIEalpha-type domain-containing protein PHD-type domain-containing protein Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein FUS TAFII28-like protein domain-containing protein TAFII55 protein conserved region domain-containing protein TAFII55 protein conserved region domain-containing protein TATA-box-binding protein Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9	E9P861 G5EF68 G5EFV5 G5EG47 G5EG49 G5EGM3 K8F7X5 O02092 O16991 O17245 O44499 O44625 O45784 O61707 P16356 P32085 P34567 Q09645 Q10578 Q17558 Q17684 Q17957 Q18265 Q19826 Q20361 Q20788 Q8MYM8 Q93338 Q95PZ4 Q95ZS0 Q965S0 Q9GR61 Q9GZI6 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9NEW8 Q9NEX2 Q9TYN3 Q9U226 Q9U3I0 Q9XVH6	TFIIE-alpha TFIIE-beta ama-1 cdk-7 fust-1 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 mnat-1 pqn-51 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 taf-1 taf-10 taf-11 taf-11.3 taf-12 taf-13 taf-2 taf-3 taf-4 taf-5 taf-6.1 taf-7.1 taf-7.2 taf-9 tbp tbp-1 ttb-1 xpb-1 xpd-1	Caenorhabditis elegans
RNA Polymerase II Promoter Escape	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cyclin-dependent kinase 7 DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 HTH TFE/IIEalpha-type domain-containing protein PHD-type domain-containing protein Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 RNA polymerase Rpb4/RPC9 core domain-containing protein RNA-binding protein FUS TAFII28-like protein domain-containing protein TAFII55 protein conserved region domain-containing protein TAFII55 protein conserved region domain-containing protein TATA-box-binding protein Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9	E9P861 G5EF68 G5EFV5 G5EG47 G5EG49 G5EGM3 K8F7X5 O02092 O16991 O17245 O44499 O44625 O45784 O61707 P16356 P32085 P34567 Q09645 Q10578 Q17558 Q17684 Q17957 Q18265 Q19826 Q20361 Q20788 Q8MYM8 Q93338 Q95PZ4 Q95ZS0 Q965S0 Q9GR61 Q9GZI6 Q9N390 Q9N3C9 Q9N3L2 Q9N5K2 Q9NEW8 Q9NEX2 Q9TYN3 Q9U226 Q9U3I0 Q9XVH6	TFIIE-alpha TFIIE-beta ama-1 cdk-7 fust-1 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 mnat-1 pqn-51 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 taf-1 taf-10 taf-11 taf-11.3 taf-12 taf-13 taf-2 taf-3 taf-4 taf-5 taf-6.1 taf-7.1 taf-7.2 taf-9 tbp tbp-1 ttb-1 xpb-1 xpd-1	Caenorhabditis elegans
Sphingolipid catabolism	Aldehyde dehydrogenase Aldehyde dehydrogenase Alkaline ceramidase Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein Phospholipid phosphatase homolog 1.2 homolog Sphingosine-1-phosphate lyase	A0A486WWU7 H2KZD1 O44555 O45145 Q10022 Q19403 Q9Y194	W02F12.2 alh-4 alh-5 plpp-1.1 plpp-1.2 plpp-1.3 spl-1	Caenorhabditis elegans
Ion transport by P-type ATPases	Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium-transporting ATPase Calcium/calmodulin-dependent protein kinase type II Cation-transporting ATPase catp-5 Cation-transporting ATPase EF-hand domain-containing protein P-type Cu(+) transporter Phospholipid-transporting ATPase tat-1 Phospholipid-transporting ATPase Phospholipid-transporting ATPase Phospholipid-transporting ATPase Phospholipid-transporting ATPase Plasma membrane calcium-transporting ATPase mca-1 Probable cation-transporting ATPase W08D2.5 Probable manganese-transporting ATPase catp-8 Probable phospholipid-transporting ATPase tat-5	G5EBH1 G5EDU1 G5EE14 G5EEK8 G5EFR6 O18182 O62305 P90747 P91203 Q18136 Q21286 Q27533 Q7JPE3 Q95XP5 Q9N323 Q9TYP9 Q9U280 U4PBV8	W08D2.5 cal-5 catp-5 catp-7 catp-8 cua-1 mca-1 mca-2 mca-3 mca-4 pmr-1 sca-1 tat-1 tat-2 tat-3 tat-4 tat-5 tat-6 unc-43	Caenorhabditis elegans
Nuclear Receptor transcription pathway	Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear Hormone Receptor family Nuclear hormone receptor 114 Nuclear hormone receptor E75 Nuclear hormone receptor family member daf-12 Nuclear hormone receptor family member fax-1 Nuclear hormone receptor family member nhr-100 Nuclear hormone receptor family member nhr-10 Nuclear hormone receptor family member nhr-136 Nuclear hormone receptor family member nhr-14 Nuclear hormone receptor family member nhr-153 Nuclear hormone receptor family member nhr-154 Nuclear hormone receptor family member nhr-1 Nuclear hormone receptor family member nhr-209 Nuclear hormone receptor family member nhr-23 Nuclear hormone receptor family member nhr-25 Nuclear hormone receptor family member nhr-2 Nuclear hormone receptor family member nhr-35 Nuclear hormone receptor family member nhr-3 Nuclear hormone receptor family member nhr-40 Nuclear hormone receptor family member nhr-47 Nuclear hormone receptor family member nhr-48 Nuclear hormone receptor family member nhr-49 Nuclear hormone receptor family member nhr-60 Nuclear hormone receptor family member nhr-64 Nuclear hormone receptor family member nhr-67 Nuclear hormone receptor family member nhr-68 Nuclear hormone receptor family member nhr-69 Nuclear hormone receptor family member nhr-6 Nuclear hormone receptor family member nhr-76 Nuclear hormone receptor family member nhr-7 Nuclear hormone receptor family member nhr-85 Nuclear hormone receptor family member nhr-8 Nuclear hormone receptor family member nhr-91 Nuclear hormone receptor unc-55 Nuclear receptor corepressor 1 Nuclear receptor domain-containing protein Nuclear receptor domain-containing protein Nuclear receptor Nuclear receptor Nuclear receptor Nuclear receptor Nuclear receptor Nuclear receptor Steroid hormone receptor family member cnr14	A0A0K3AVS8 A0A131MB42 A0A131MBQ7 A5JYV4 B3WFU1 G5ECR9 G5EDJ0 G5EE21 G5EEM0 G5EET0 G5EFF5 H2KYV4 O01446 O01448 O01929 O01930 O01931 O02151 O16890 O17611 O17898 O44960 O45666 O61939 P34333 P41828 P41829 P41830 P41999 P91829 P91983 Q10902 Q17370 Q17589 Q17771 Q17929 Q18190 Q18895 Q19155 Q19345 Q20765 Q21104 Q21803 Q21804 Q21805 Q21806 Q21878 Q22127 Q3V5L2 Q65CM0 Q94407 Q95ZS3 Q9N2W3 Q9U2R6 Q9XTJ4 Q9XUK7 Q9XVV3 Q9XXM8 Q9XYB7	XL285 chr-3 cnr-14 cnr-3 cnr-8 csr-1 daf-12 daf-20 fax-1 gei-8 let-527 mig-7 nhr-1 nhr-10 nhr-100 nhr-101 nhr-114 nhr-116 nhr-118 nhr-120 nhr-129 nhr-136 nhr-137 nhr-14 nhr-141 nhr-147 nhr-148 nhr-149 nhr-152 nhr-153 nhr-154 nhr-168 nhr-17 nhr-173 nhr-2 nhr-204 nhr-206 nhr-207 nhr-208 nhr-209 nhr-221 nhr-23 nhr-24 nhr-25 nhr-258 nhr-277 nhr-3 nhr-35 nhr-36 nhr-38 nhr-40 nhr-41 nhr-47 nhr-48 nhr-49 nhr-6 nhr-60 nhr-64 nhr-67 nhr-68 nhr-69 nhr-7 nhr-76 nhr-8 nhr-85 nhr-91 nhr-93 nr1g1 nr4a5 pqn-12 sex-1 unc-55	Caenorhabditis elegans
Vitamin D (calciferol) metabolism	3-ketosteroid oxygenase Nuclear hormone receptor family member daf-12 Nuclear hormone receptor family member nhr-48 Nuclear hormone receptor family member nhr-8 Suppressor of lurcher protein 1	G5EFF5 H2KYS3 Q93212 Q94407 Q9XYB7	XL285 daf-12 daf-20 daf-9 mig-7 nhr-48 nhr-8 sol-1	Caenorhabditis elegans
Neurotransmitter release cycle	N-acylethanolamine-hydrolyzing acid amidase	Q9GUI1	Y55D5A.3	Caenorhabditis elegans

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