GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **151 - 175** of **499** in total

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Pathway Name	Protein Name	UniProt ID ▲	Gene Symbol	Organism
Antigen Presentation: Folding, assembly and peptide loading of class I MHC	ABC-type antigen peptide transporter ABC-type antigen peptide transporter ABC-type antigen peptide transporter Aminopeptidase-like protein AC3.5 Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase Aminopeptidase HAlF transporter (PGP related) HAlF transporter (PGP related) Peptidase_M1 domain-containing protein Protein transport protein SEC23 Protein transport protein Sec24C Puromycin-sensitive aminopeptidase Putative aminopeptidase-2 Small COPII coat GTPase SAR1 Yeast SEC homolog	A5A631 G5EGH4 H2L0M5 O02086 O18227 O44897 Q17405 Q19371 Q22317 Q22531 Q23368 Q23445 Q4TT88 Q9NAA0 Q9TZD9 Q9U275 Q9U2H2 Q9U2Z1 Q9XVV9	AC3.5 CELE_F49B2.6 CELE_R03G8.6 CELE_T12E12.6 CELE_Y42A5A.1 CELE_Y53F4B.20 CELE_Y67D8C.9 T16G12.1 anp-1 haf-2 haf-4 haf-7 haf-8 haf-9 pam-1 sar-1 sec-23 sec-24.1 sec-24.2	Caenorhabditis elegans
Dopamine Neurotransmitter Release Cycle	ATP-grasp domain-containing protein Acetylcholine regulator unc-18 Liprin-alpha Major facilitator superfamily (MFS) profile domain-containing protein Phorbol ester/diacylglycerol-binding protein unc-13 Protein lin-10 Protein lin-2 Protein lin-7 homolog Putative complexin-1 Rab-3-interacting molecule unc-10 Ras-related protein Rab-3 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Synaptotagmin-1 Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Variant SH3 domain protein t-SNARE protein aex-4	A5PEW5 A5PEX5 G5EBK2 G5EEN8 O02495 O16000 O17583 P27715 P34351 P34693 P34815 P54936 Q19767 Q21049 Q22366 Q8MXU3 Q94057 Q94986 Q95XH1 Q9GNP0 Q9GUM7 Q9N415	aex-4 cat-1 cpx-1 lan-2 lin-10 lin-2 lin-7 rab-3 ric-4 rimb-1 snb-1 snb-2 snb-5 snb-6 snb-7 snn-1 snt-1 syd-2 tag-168 tag-81 unc-10 unc-13 unc-18 unc-64 vamp-7	Caenorhabditis elegans
GABA synthesis, release, reuptake and degradation	Acetylcholine regulator unc-18 Glutamate decarboxylase 1 Heat shock protein hsp-1 J domain-containing protein Putative complexin-1 Rab-3-interacting molecule unc-10 Ras-related protein Rab-3 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Synaptotagmin-1 Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Vesicular GABA transporter t-SNARE protein aex-4	A5PEW5 E5QCE7 G5EBK2 G5EDB7 G5EEN8 O02495 O16000 P09446 P34351 P34579 P34693 P34815 Q19767 Q22366 Q94057 Q94986 Q95XH1 Q9GUM7	aex-4 cpx-1 dnj-14 hsp-1 hsp70a lan-2 rab-3 ric-4 snb-1 snb-2 snb-5 snb-6 snb-7 snt-1 tag-81 unc-10 unc-18 unc-25 unc-47 unc-64 vamp-7	Caenorhabditis elegans
Glutamate Neurotransmitter Release Cycle	Acetylcholine regulator unc-18 Amino acid transporter Amino acid transporter Excitatory amino acid transporter Liprin-alpha Major facilitator superfamily (MFS) profile domain-containing protein PRA1 family protein Phorbol ester/diacylglycerol-binding protein unc-13 Potential vesicular glutamate transporter vglu-3 Probable vesicular glutamate transporter eat-4 Putative complexin-1 Putative glutaminase 2 Putative glutaminase 3 Putative sodium-dependent excitatory amino acid transporter glt-3 Putative sodium-dependent excitatory amino acid transporter glt-4 Putative sodium-dependent excitatory amino acid transporter glt-6 Rab-3-interacting molecule unc-10 Ras-related protein Rab-3 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Synaptotagmin-1 Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Variant SH3 domain protein glutaminase t-SNARE protein aex-4	A5PEW5 G5EBK2 G5EEK1 G5EEN8 H2KZJ7 O02495 O16000 O18210 P27715 P34351 P34644 P34693 P34815 Q10046 Q10901 Q19013 Q19767 Q21049 Q21353 Q21751 Q22366 Q22682 Q93650 Q94057 Q94986 Q95XH1 Q9GUM7 Q9N415 Q9UAY8 U4PRW7	aex-4 cpx-1 eat-4 glna-1 glna-2 glna-3 glt-1 glt-3 glt-4 glt-5 glt-6 glt-7 lan-2 praf-3 rab-3 ric-4 rimb-1 snb-1 snb-2 snb-5 snb-6 snb-7 snt-1 syd-2 tag-168 tag-81 unc-10 unc-13 unc-18 unc-64 vamp-7 vglu-2 vglu-3	Caenorhabditis elegans
trans-Golgi Network Vesicle Budding	ADP-ribosylation factor 1-like 1 ADP-ribosylation factor 1-like 2 E3 ubiquitin-protein ligase arc-1 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 homolog Putative syntaxin-2 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein t-SNARE protein aex-4	A5PEW5 G5EBK2 G5EEN8 G5EGS5 O02495 O16000 P34351 Q09654 Q10943 Q19767 Q20574 Q94057 Q94231 Q95XH1	aex-4 arc-1 arf-1 arf-1.1 arf-1.2 arl-4 arl-6 gbf-1 phi-34 ric-4 snb-1 snb-2 snb-5 snb-6 snb-7 syn-2 syx-2 tag-81 unc-64 vamp-7	Caenorhabditis elegans
Acetylcholine Neurotransmitter Release Cycle	Acetylcholine regulator unc-18 Choline O-acetyltransferase High-affinity choline transporter 1 Liprin-alpha Phorbol ester/diacylglycerol-binding protein unc-13 Putative complexin-1 Rab-3-interacting molecule unc-10 Ras-related protein Rab-3 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Synaptotagmin-1 Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Variant SH3 domain protein Vesicular acetylcholine transporter unc-17 t-SNARE protein aex-4	A5PEW5 G5EBK2 G5EEN8 O02228 O02495 O16000 P27715 P32756 P34351 P34693 P34711 P34815 Q19767 Q21049 Q22366 Q94057 Q94986 Q95XH1 Q9GUM7 Q9N415	aex-4 cha-1 cho-1 cpx-1 lan-2 rab-3 ric-4 rimb-1 snb-1 snb-2 snb-5 snb-6 snb-7 snt-1 syd-2 tag-168 tag-81 unc-10 unc-13 unc-17 unc-18 unc-64 vamp-7	Caenorhabditis elegans
Serotonin Neurotransmitter Release Cycle	ATP-grasp domain-containing protein Acetylcholine regulator unc-18 Liprin-alpha Major facilitator superfamily (MFS) profile domain-containing protein Phorbol ester/diacylglycerol-binding protein unc-13 Putative complexin-1 Rab-3-interacting molecule unc-10 Ras-related protein Rab-3 Synaptobrevin-1 Synaptobrevin-like protein 5 Synaptosomal-associated protein Synaptotagmin-1 Syntaxin-1A homolog V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein V-SNARE coiled-coil homology domain-containing protein Variant SH3 domain protein t-SNARE protein aex-4	A5PEW5 G5EBK2 G5EEN8 O02495 O16000 P27715 P34351 P34693 P34815 Q19767 Q21049 Q22366 Q8MXU3 Q94057 Q94986 Q95XH1 Q9GNP0 Q9GUM7 Q9N415	aex-4 cat-1 cpx-1 lan-2 rab-3 ric-4 rimb-1 snb-1 snb-2 snb-5 snb-6 snb-7 snn-1 snt-1 syd-2 tag-168 tag-81 unc-10 unc-13 unc-18 unc-64 vamp-7	Caenorhabditis elegans
RNA polymerase II transcribes snRNA genes	Beta-Casp domain-containing protein C3H1-type domain-containing protein CID domain-containing protein 1 CID domain-containing protein Cyclin-T1.1 Cyclin-T1.2 Cyclin-dependent kinase 7 Cyclin-like domain-containing protein DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 DUF3677 domain-containing protein General transcription factor IIF subunit 2 HTH TFE/IIEalpha-type domain-containing protein INTegrator complex Subunit homolog INTegrator complex Subunit homolog INTegrator complex Subunit homolog Integrator complex subunit 11 Integrator complex subunit 5 Integrator complex subunit 7 Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 OB domain-containing protein OCEL domain-containing protein PHD-type domain-containing protein Phosphorylated adapter RNA export protein Polyadenylation and cleavage factor homolog 11 Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cyclin-dependent kinase 9 Protein asunder Putative RNA polymerase II subunit B1 CTD phosphatase rpap-2 RNA polymerase II subunit A C-terminal domain phosphatase ssup-72 RNA polymerase Rpb4/RPC9 core domain-containing protein SOSS complex subunit A homolog Serrate RNA effector molecule homolog TAFII28-like protein domain-containing protein TATA-box-binding protein Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 8 Transcription initiation factor TFIID subunit 9 VWFA domain-containing protein snRNA-activating protein complex subunit 1 snRNA-activating protein complex subunit 3 snRNA-activating protein complex subunit 4 homolog	A5Z2V1 B7WN63 E5QCH1 G5EDW9 G5EF68 G5EFV5 G5EG47 G5EG49 H2KML7 O01483 O01763 O02092 O16991 O17869 O18167 O44500 O44625 O45075 O45784 P16356 P30641 P32085 P34281 P34424 P34425 P91868 Q09345 Q10578 Q17558 Q17684 Q17694 Q17749 Q17957 Q19826 Q20361 Q22453 Q22805 Q7YTH5 Q8MYM8 Q93338 Q93594 Q95ZM2 Q965S0 Q965U6 Q966L5 Q9GR61 Q9GZI6 Q9N3C9 Q9N4E8 Q9N554 Q9N5K2 Q9NEX2 Q9TVL3 Q9U267 Q9U3I0 Q9U3K2 Q9XVH6 W6RQY9	C06G3.8 CELE_F53H1.4 CELE_T26A8.4 CELE_Y71H2B.2 E01A2.2 TFIIE-alpha TFIIE-beta ama-1 cbp-20 cbp-80 ccnk-1 cdk-7 cdk-9 cids-1 cids-2 cit-1.1 cit-1.2 dic-1 ell-1 gei-11 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 inst-1 ints-1 ints-11 ints-13 ints-2 ints-3 ints-4 ints-5 ints-6 ints-7 ints-8 ints-9 ncbp-1 ncbp-2 pcf-11 pqn-51 rpap-2 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 snpc-1.1 snpc-3.2 snpc-4 ssup-72 taf-10 taf-11.3 taf-13 taf-5 taf-6.1 taf-8 taf-9 tbp tbp-1 ttb-1	Caenorhabditis elegans
RNA Polymerase II Pre-transcription Events	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cell division cycle protein 73 Cyclin-T1.1 Cyclin-T1.2 Cyclin-dependent kinase 7 Cyclin-like domain-containing protein DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Ell-associated factor Eaf Elongin-C FACT complex subunit SSRP1-A FACT complex subunit spt-16 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 HTH TFE/IIEalpha-type domain-containing protein IWS1-like protein Nuclear cap-binding protein subunit 1 Nuclear cap-binding protein subunit 2 OCEL domain-containing protein PHD-type domain-containing protein Prion-like-(Q/N-rich)-domain-bearing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cyclin-dependent kinase 9 Putative transcription elongation factor S-II RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II transcription factor SIII p18 subunit RNA polymerase II-associated factor 1 homolog RNA polymerase Rpb4/RPC9 core domain-containing protein RNA polymerase-associated protein CTR9 RNA polymerase-associated protein LEO1 RNA-binding protein FUS Suppressor of Ty 6 homolog TAFII28-like protein domain-containing protein TAFII55 protein conserved region domain-containing protein TAFII55 protein conserved region domain-containing protein TATA-box-binding protein Transcription elongation factor B polypeptide 3 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription initiation factor IIA subunit 2 Transcription initiation factor IIB Transcription initiation factor IIE subunit beta Transcription initiation factor IIF subunit alpha Transcription initiation factor TFIID subunit 10 Transcription initiation factor TFIID subunit 12 Transcription initiation factor TFIID subunit 13 Transcription initiation factor TFIID subunit 1 Transcription initiation factor TFIID subunit 2 Transcription initiation factor TFIID subunit 4 Transcription initiation factor TFIID subunit 5 Transcription initiation factor TFIID subunit 6 Transcription initiation factor TFIID subunit 9 WD_REPEATS_REGION domain-containing protein	A5Z2V7 E9P861 G5ECR7 G5EF68 G5EFV5 G5EG47 G5EG49 G5EGM3 K8F7X5 O01763 O02092 O16991 O17245 O17869 O44499 O44625 O45784 O61707 P16356 P32085 P34424 P34425 P34567 P34703 P41848 P52652 P90783 Q03560 Q09413 Q09645 Q10578 Q17431 Q17558 Q17684 Q17957 Q18265 Q19375 Q19826 Q20361 Q20788 Q21338 Q8MYM8 Q93338 Q93594 Q95PZ4 Q95QG8 Q95ZS0 Q965S0 Q9BKS1 Q9GR61 Q9GZI6 Q9N390 Q9N3C9 Q9N3L2 Q9N554 Q9N5K2 Q9N5R9 Q9N5U5 Q9NEW8 Q9NEX2 Q9TVL3 Q9TXQ9 Q9TYN3 Q9TZ93 Q9U226 Q9U3I0 Q9XVH6	3L686 CELE_F02E9.10 F13B12.1 T24H10.1 TFIIE-alpha TFIIE-beta ama-1 cbp-20 cbp-80 ccnk-1 cdc-73 cdk-7 cdk-9 cit-1.1 cit-1.2 ctr-9 eaf-1 elb-1 elc-1 ell-1 emb-5 fcp-1 fust-1 gtf-2A2 gtf-2E1 gtf-2E2 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2e1 gtf-2e2 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 hmg-4 leo-1 mnat-1 ncbp-1 ncbp-2 pafo-1 pqn-51 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 spt-16 spt-4 spt-5 taf-1 taf-10 taf-11 taf-11.3 taf-12 taf-13 taf-2 taf-3 taf-4 taf-5 taf-6.1 taf-7.1 taf-7.2 taf-9 tbp tbp-1 tceb-3 tpr-3 ttb-1 xpb-1 xpd-1	Caenorhabditis elegans
RNA Polymerase II Transcription Elongation	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cell division cycle protein 73 Cyclin-T1.1 Cyclin-T1.2 Cyclin-dependent kinase 7 Cyclin-like domain-containing protein DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Ell-associated factor Eaf Elongin-C FACT complex subunit SSRP1-A FACT complex subunit spt-16 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 IWS1-like protein OCEL domain-containing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cyclin-dependent kinase 9 Putative transcription elongation factor S-II RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II transcription factor SIII p18 subunit RNA polymerase II-associated factor 1 homolog RNA polymerase Rpb4/RPC9 core domain-containing protein RNA polymerase-associated protein CTR9 RNA polymerase-associated protein LEO1 Suppressor of Ty 6 homolog Transcription elongation factor B polypeptide 3 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription initiation factor IIF subunit alpha WD_REPEATS_REGION domain-containing protein	A5Z2V7 G5ECR7 G5EFV5 K8F7X5 O02092 O17245 O17869 O44499 P16356 P34424 P34425 P34567 P34703 P41848 P52652 P90783 Q03560 Q09413 Q09645 Q10578 Q17431 Q17558 Q17684 Q19375 Q19826 Q21338 Q8MYM8 Q93338 Q95PZ4 Q95QG8 Q965S0 Q9BKS1 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N554 Q9N5K2 Q9N5R9 Q9N5U5 Q9TVL3 Q9TXQ9 Q9TZ93 Q9U3I0 Q9XVH6	3L686 CELE_F02E9.10 F13B12.1 T24H10.1 ama-1 ccnk-1 cdc-73 cdk-7 cdk-9 cit-1.1 cit-1.2 ctr-9 eaf-1 elb-1 elc-1 ell-1 emb-5 fcp-1 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 hmg-4 leo-1 mnat-1 pafo-1 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 spt-16 spt-4 spt-5 tceb-3 tpr-3 xpb-1 xpd-1	Caenorhabditis elegans
Formation of RNA Pol II elongation complex	BSD domain-containing protein CDK-activating kinase assembly factor MAT1 Cell division cycle protein 73 Cyclin-T1.1 Cyclin-T1.2 Cyclin-dependent kinase 7 Cyclin-like domain-containing protein DNA-directed RNA polymerase II subunit RPB1 DNA-directed RNA polymerase II subunit RPB2 DNA-directed RNA polymerase II subunit RPB7 DNA-directed RNA polymerase II subunit rpb-9 DNA-directed RNA polymerase RpoA/D/Rpb3-type domain-containing protein DNA-directed RNA polymerases I, II, and III subunit RPABC1 DNA-directed RNA polymerases I, II, and III subunit RPABC4 DNA-directed RNA polymerases I, II, and III subunit RPABC5 Ell-associated factor Eaf Elongin-C FACT complex subunit SSRP1-A FACT complex subunit spt-16 General transcription and DNA repair factor IIH helicase subunit XPB General transcription and DNA repair factor IIH helicase subunit XPD General transcription and DNA repair factor IIH subunit TFB5 General transcription factor IIF subunit 2 General transcription factor IIH subunit 2 General transcription factor IIH subunit 3 General transcription factor IIH subunit 4 IWS1-like protein OCEL domain-containing protein Probable DNA-directed RNA polymerase II subunit RPB11 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC2 Probable DNA-directed RNA polymerases I, II, and III subunit RPABC3 Probable cyclin-dependent kinase 9 Putative transcription elongation factor S-II RNA polymerase II subunit A C-terminal domain phosphatase RNA polymerase II transcription factor SIII p18 subunit RNA polymerase II-associated factor 1 homolog RNA polymerase Rpb4/RPC9 core domain-containing protein RNA polymerase-associated protein CTR9 RNA polymerase-associated protein LEO1 Suppressor of Ty 6 homolog Transcription elongation factor B polypeptide 3 Transcription elongation factor SPT4 Transcription elongation factor SPT5 Transcription initiation factor IIF subunit alpha WD_REPEATS_REGION domain-containing protein	A5Z2V7 G5ECR7 G5EFV5 K8F7X5 O02092 O17245 O17869 O44499 P16356 P34424 P34425 P34567 P34703 P41848 P52652 P90783 Q03560 Q09413 Q09645 Q10578 Q17431 Q17558 Q17684 Q19375 Q19826 Q21338 Q8MYM8 Q93338 Q95PZ4 Q95QG8 Q965S0 Q9BKS1 Q9GR61 Q9N390 Q9N3C9 Q9N3L2 Q9N554 Q9N5K2 Q9N5R9 Q9N5U5 Q9TVL3 Q9TXQ9 Q9TZ93 Q9U3I0 Q9XVH6	3L686 CELE_F02E9.10 F13B12.1 T24H10.1 ama-1 ccnk-1 cdc-73 cdk-7 cdk-9 cit-1.1 cit-1.2 ctr-9 eaf-1 elb-1 elc-1 ell-1 emb-5 fcp-1 gtf-2F1 gtf-2F2 gtf-2H1 gtf-2H2C gtf-2H3 gtf-2H4 gtf-2H5 gtf-2f1 gtf-2f2 gtf-2h1 gtf-2h3 hmg-4 leo-1 mnat-1 pafo-1 rpb-1 rpb-10 rpb-11 rpb-12 rpb-2 rpb-3 rpb-4 rpb-5 rpb-6 rpb-7 rpb-8 rpb-9 spt-16 spt-4 spt-5 tceb-3 tpr-3 xpb-1 xpd-1	Caenorhabditis elegans
G alpha (s) signalling events	Bursicon Dopamine receptor 2 G protein gamma domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein G_PROTEIN_RECEP_F1_2 domain-containing protein Glycoprotein hormone subunit beta domain-containing protein Guanine nucleotide-binding protein G(s) subunit alpha Guanine nucleotide-binding protein subunit beta-1 Guanine nucleotide-binding protein subunit beta-2 Guanine nucleotide-binding protein subunit gamma Probable 3',5'-cyclic phosphodiesterase pde-1 Probable 3',5'-cyclic phosphodiesterase pde-2 Probable 3',5'-cyclic phosphodiesterase pde-3 Probable 3',5'-cyclic phosphodiesterase pde-5 Probable 3',5'-cyclic phosphodiesterase pde-6 Probable 3',5'-cyclic-AMP phosphodiesterase pde-4	A7DT38 E7EM37 G5ECT6 G5EGH0 H2KZ99 L8EC40 O18014 O18696 P17343 P30645 P54406 P91119 Q17553 Q19779 Q1ZXT2 Q20636 Q20827 Q21013 Q22000 Q22895 Q7KPV0 Q86ME6 Q8I0P7 Q9N2V9 Q9XUK8	CELE_F55D10.4 ador-1 dop-1 dop-2 dop-2L eat-11 flr-2 fshr-1 gbp-2 gnrr-4 gpb-1 gpb-2 gpb5 gpc-1 gpc-2 gplb-1 gsa-1 gtr-1 npr-14 npr-25 npr-42 pde-1 pde-2 pde-3 pde-4 pde-5 pde-6 ser-4 ser-7	Caenorhabditis elegans
Synthesis of bile acids and bile salts	Cholesterol 25-hydroxylase-like protein Oxysterol-binding protein Oxysterol-binding protein Oxysterol-binding protein	A7DTF2 O01686 Q20027 Q93485	F35C8.5 obr-1 obr-2 obr-4	Caenorhabditis elegans
Protein methylation	Electron transfer flavoprotein beta subunit lysine methyltransferase homolog Electron transfer flavoprotein subunit beta Elongation factor 1-alpha Protein-lysine N-methyltransferase CELE_F29B9.1 Protein-lysine N-methyltransferase M142.8 Protein-lysine methyltransferase C42C1.13 Transitional endoplasmic reticulum ATPase homolog 2	A7IQW5 O01503 P53013 P54812 Q5WRN3 Q9GYH9 Q9TXI4	C37A2.6 C42C1.13 CELE_F23C8.5 CELE_F29B9.1 M142.8 cdc-48.2 eft-3 eft-4	Caenorhabditis elegans
Adherens junctions interactions	Afadin Ig-like domain-containing protein	A7LPD6 Q86NJ4	afd-1 igcm-3	Caenorhabditis elegans
Nectin/Necl trans heterodimerization	Ig-like domain-containing protein	A7LPD6	igcm-3	Caenorhabditis elegans
Regulation of TLR by endogenous ligand	BPI1 domain-containing protein BPI2 domain-containing protein BPI2 domain-containing protein BPI2 domain-containing protein High mobility group protein 1.2 Lipid-binding serum glycoprotein C-terminal domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Nose resistant to fluoxetine protein 5 Uncharacterized protein T19C3.5	A8WFJ7 H9G2Z8 O17768 Q09390 Q10011 Q17654 Q17738 Q18869 Q20380 Q23365 Q93796	C05C9.1 C06E8.5 C06G1.1 C55C3.1 CELE_F01G10.10 CELE_F10D11.6 CELE_F44A2.3 CELE_ZC513.2 T19C3.5 hmg-1.2 nrf-5	Caenorhabditis elegans
Toll Like Receptor 4 (TLR4) Cascade	BPI1 domain-containing protein BPI2 domain-containing protein BPI2 domain-containing protein BPI2 domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Lipid-binding serum glycoprotein C-terminal domain-containing protein Nose resistant to fluoxetine protein 5 Uncharacterized protein T19C3.5	A8WFJ7 H9G2Z8 O17768 Q10011 Q17654 Q17738 Q18869 Q20380 Q23365 Q93796	C05C9.1 C06E8.5 C06G1.1 C55C3.1 CELE_F01G10.10 CELE_F10D11.6 CELE_F44A2.3 CELE_ZC513.2 T19C3.5 nrf-5	Caenorhabditis elegans
VxPx cargo-targeting to cilium	Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-binding domain-containing protein Cyclic nucleotide-gated cation channel Exocyst complex component 1 Exocyst complex component 2 Exocyst complex component 3 Exocyst complex component 4 Exocyst complex component 5 Exocyst complex component 6 Exocyst complex component 7 Exocyst component Exo84 C-terminal domain-containing protein FIP-RBD domain-containing protein G-protein coupled receptors family 1 profile domain-containing protein GDP/GTP exchange factor Sec2 N-terminal domain-containing protein Polycystin-2 RAB family Rab8 Ras-related protein rab-11.1	A8WI01 G5EEE2 G5EFC1 O01803 O01818 O61827 P91149 Q03611 Q18286 Q18406 Q19262 Q20678 Q20759 Q21137 Q22706 Q7Z205 Q95Q35 Q95ZS6 Q9N4C1 Q9U1S7 Q9XWS2	CELE_F54C9.11 CELE_F57C9.6 che-6 cng-1 cng-2 cng-3 exoc-7 exoc-8 pdk-2 pkd-2 rab-11.1 rab-8 rab8 rabr-1 rfip-1 sec-10 sec-15 sec-3 sec-5 sec-6 sec-8 tax-2 tax-4	Caenorhabditis elegans
RAF activation	14-3-3-like protein 1 14-3-3-like protein 2 BRCA1-associated protein homolog 2 GTP binding protein Kinase suppressor of Ras A Leucine-rich repeat protein soc-2 Mitochondrial prohibitin complex protein 1 Probable serine/threonine-protein phosphatase PP2A regulatory subunit Protein kinase domain-containing protein Raf homolog serine/threonine-protein kinase Ras protein let-60 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein kinase par-1 Serine/threonine-protein phosphatase 2A catalytic subunit Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 Serine/threonine-protein phosphatase PP1-alpha Serine/threonine-protein phosphatase	A9UJN4 G5EC18 G5EFD2 G5EGA7 G5EGK8 O18178 P22981 P41932 Q07292 Q09543 Q20655 Q22875 Q27497 Q95QN6 Q9BKU4 Q9NAC7 Q9TW45	CELE_Y53F4B.1 Ras2 brap-2 ftt-1 ftt-2 gsp-1 ksr-1 let-60 let-92 lin-34 lin-45 paa-1 par-1 par-5 phb-1 pph-1 pptr-1 pptr-2 raf-1 ras-2 soc-2 sur-8	Caenorhabditis elegans
Degradation of beta-catenin by the destruction complex	26S protease regulatory subunit 6A 26S proteasome non-ATPase regulatory subunit 13 26S proteasome non-ATPase regulatory subunit 14 26S proteasome non-ATPase regulatory subunit 1 26S proteasome non-ATPase regulatory subunit 2 26S proteasome non-ATPase regulatory subunit 3 26S proteasome non-ATPase regulatory subunit 4 26S proteasome non-ATPase regulatory subunit 5 26S proteasome non-ATPase regulatory subunit 6 26S proteasome non-ATPase regulatory subunit 8 26S proteasome regulatory subunit 7 26S proteasome regulatory subunit 8 Adenomatous polyposis coli protein-related protein 1 Axin-like protein pry-1 Beta-catenin-like protein hmp-2 Casein kinase I isoform alpha Cullin-1 Glycogen synthase kinase-3 MPN domain-containing protein PCI domain-containing protein Polyubiquitin-A Probable 26S proteasome non-ATPase regulatory subunit 9 Probable 26S proteasome regulatory subunit 10B Probable 26S proteasome regulatory subunit 4 Probable 26S proteasome regulatory subunit 6B Probable 26S proteasome regulatory subunit rpn-6.1 Probable serine/threonine-protein phosphatase PP2A regulatory subunit Proteasome activator complex subunit 3 Proteasome activator complex subunit 4 Proteasome subunit alpha type-1 Proteasome subunit alpha type-2 Proteasome subunit alpha type-4 Proteasome subunit alpha type-5 Proteasome subunit alpha type-6 Proteasome subunit alpha type-7 Proteasome subunit beta type-2 Proteasome subunit beta type-3 Proteasome subunit beta Proteasome subunit beta Proteasome subunit beta Proteasome subunit pbs-5 Protein kinase domain-containing protein Putative serine/threonine-protein kinase R03D7.5 RING-box protein 1 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 Skp1-related protein Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A9UJN4 G5ECU1 G5EGK8 O16368 O17071 O17586 O18178 O44156 O44326 O61742 O61792 O62090 O62102 O76371 O76577 P0CG71 P37165 P42168 P46502 P49632 P90868 P91477 Q04908 Q09543 Q09595 Q10920 Q17389 Q17971 Q18115 Q18787 Q19324 Q20058 Q20585 Q20938 Q21227 Q22253 Q23237 Q23449 Q23457 Q27488 Q93372 Q95005 Q95008 Q95PZ7 Q966I8 Q9GZH5 Q9N599 Q9U2Q9 Q9XTT9 Q9XUV0	C14C10.5 C44H4.6 CELE_F35G12.12 R03D7.5 apr-1 cul-1 gsk-3 hmp-2 kin-19 let-92 lin-19 paa-1 pas-1 pas-2 pas-3 pas-4 pas-5 pas-6 pbs-1 pbs-2 pbs-3 pbs-4 pbs-5 pbs-7 pptr-1 pptr-2 pry-1 psmd-9 psme-3 rbx-1 rpn-1 rpn-10 rpn-11 rpn-12 rpn-2 rpn-3 rpn-5 rpn-6.1 rpn-7 rpn-8 rpn-9 rpt-1 rpt-2 rpt-3 rpt-4 rpt-5 rpt-6 sgg-1 skr-1 ubia ubib ubl-1 ubq-1 ubq-2	Caenorhabditis elegans
Negative regulation of MAPK pathway	14-3-3-like protein 1 14-3-3-like protein 2 BRCA1-associated protein homolog 2 Dual specificity protein phosphatase lip-1 Kinase suppressor of Ras A Mitogen-activated protein kinase mpk-1 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 Phosphatidylethanolamine-binding protein homolog F40A3.3 Polyubiquitin-A Probable serine/threonine-protein phosphatase PP2A regulatory subunit Progestin and AdipoQ Receptor family Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Raf homolog serine/threonine-protein kinase Ras protein let-60 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein kinase par-1 Serine/threonine-protein phosphatase 2A catalytic subunit Serine/threonine-protein phosphatase 2A regulatory subunit pptr-1 Serine/threonine-protein phosphatase 5 Tyrosine-protein phosphatase 1 Tyrosine-protein phosphatase domain-containing protein Tyrosine-protein phosphatase vhp-1 Ubiquitin-like protein 1-ribosomal protein eS31 fusion protein Ubiquitin-ribosomal protein eL40 fusion protein	A9UJN4 G5EFD2 G5EFV1 G5EGK8 O16264 O18178 O44514 P0CG71 P22981 P28191 P37165 P39745 P41932 P49632 P91267 Q07292 Q09543 Q10038 Q17446 Q20655 Q8MXI4 Q93344 Q95QN6 Q9NES8 Q9TW45 Q9U1V1 Q9U3L3 Q9XUJ0 Q9XX60 Q9XXC0 V6CIV8	C49C3.10 CELE_F21F3.2 CELE_W09H1.1 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y51B9A.9 F40A3.3 brap-2 ftt-1 ftt-2 gska-3 gskl-2 ksr-1 let-60 let-92 lin-34 lin-45 lip-1 mpk-1 paa-1 paqr-3 par-1 par-5 pmk-1 pmk-2 pmk-3 pph-5 pptr-1 pptr-2 ptp-1 raf-1 sur-1 ubia ubib ubl-1 ubq-1 ubq-2 vhp-1	Caenorhabditis elegans
ERK/MAPK targets	Mitogen-activated protein kinase mpk-1 Mitogen-activated protein kinase pmk-1 Mitogen-activated protein kinase pmk-2 Mitogen-activated protein kinase pmk-3 Mitogen-activated protein kinase Probable serine/threonine-protein phosphatase PP2A regulatory subunit Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Protein kinase domain-containing protein Putative ribosomal protein S6 kinase alpha-1 Putative ribosomal protein S6 kinase alpha-2 Serine/threonine protein phosphatase 2A regulatory subunit Serine/threonine-protein phosphatase 2A catalytic subunit	A9UJN4 G5EFV1 G5EGK8 H2KYF8 O44514 P39745 P91267 Q09543 Q17446 Q18846 Q21734 Q8MXI4 Q93344 Q9U3L3 Q9XX60 Q9XXC0	C49C3.10 CELE_F21F3.2 CELE_Y106G6D.4 CELE_Y106G6E.1 CELE_Y51B9A.9 gska-3 gskl-2 let-92 mpk-1 mpk-2 paa-1 pmk-1 pmk-2 pmk-3 pptr-2 rskn-1 rskn-2 sur-1	Caenorhabditis elegans
Regulation of IGF Activity by IGFBP	Amyloid-beta-like protein Anoctamin Apolipoprotein L, 1 Apolipoprotein L3-like BMP-like protein unc-129 Calumenin-like protein Cystatin cpi-2 DUF19 domain-containing protein Dauer larva development regulatory growth factor daf-7 Disintegrin and metalloproteinase domain-containing protein 10 homolog EGL-17 Endoplasmin homolog Extracellular serine/threonine protein kinase CeFam20 Fibronectin type-III domain-containing protein Galectin domain-containing protein Glucosidase 2 subunit beta J domain-containing protein Multiple epidermal growth factor-like domains protein 6 NTR domain-containing protein NUCleoBindin homolog Nidogen PNPLA domain-containing protein PNPLA domain-containing protein Patanin-like phospholipase domain-containing protein atgl-1 Probable syndecan Protein dbl-1 Protein disulfide-isomerase 1 Protein disulfide-isomerase 2 Protein disulfide-isomerase A6 homolog Putative alpha-L-fucosidase Putative metalloproteinase inhibitor tag-225 SERPIN domain-containing protein SERPIN domain-containing protein SPARC Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Sulfhydryl oxidase Thioredoxin domain-containing protein Transmembrane protein 132 homolog VWFA domain-containing protein	A9Z1L1 G5EBH7 G5EBY8 G5EC87 G5ECM9 G5ECY2 G5EE40 G5EEF1 G5EEL5 G5EFD9 G5EFH4 G5EFX3 H2FLL2 H2KZY5 H2L2L3 O17365 O45520 P34714 P49713 P50605 P91189 P92172 Q09EE8 Q10651 Q11067 Q11186 Q17770 Q17967 Q18048 Q18096 Q18287 Q18948 Q19651 Q20684 Q21265 Q21267 Q22235 Q8MQ51 Q8WQF7 Q8WQF8 Q93791 Q9BL47 Q9N5Z7 Q9XTW2 Q9XVQ1	B0524.2 C16E9.1 C18E9.7 C28G1.2 CELE_D1054.1 CELE_F07F6.7 CELE_F07F6.8 CELE_F15D3.4 CELE_F44G3.7 CELE_F47B7.2 CELE_M04D5.1 CELE_W01A8.8 CELE_Y64G10A.7 CELE_ZK1307.8 W03G11.3 Y71H2AM.10 anoh-2 apl-1 atgl-1 calu-1 cet-1 cpi-2 daf-7 dbl-1 dnj-7 egl-17 enpl-1 famk-1 lec-2 nid-1 nucb-1 ost-1 pdi-1 pdi-2 pdi-6 sdn-1 sparc srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 sup-17 tag-225 tag-320 timp-1 unc-129	Caenorhabditis elegans
Post-translational protein phosphorylation	Amyloid-beta-like protein Anoctamin Apolipoprotein L, 1 Apolipoprotein L3-like BMP-like protein unc-129 Calumenin-like protein Cystatin cpi-2 DUF19 domain-containing protein Dauer larva development regulatory growth factor daf-7 Disintegrin and metalloproteinase domain-containing protein 10 homolog EGL-17 Endoplasmin homolog Extracellular serine/threonine protein kinase CeFam20 Fibronectin type-III domain-containing protein Galectin domain-containing protein Glucosidase 2 subunit beta J domain-containing protein Multiple epidermal growth factor-like domains protein 6 NTR domain-containing protein NUCleoBindin homolog Nidogen PNPLA domain-containing protein PNPLA domain-containing protein Patanin-like phospholipase domain-containing protein atgl-1 Probable syndecan Protein dbl-1 Protein disulfide-isomerase 1 Protein disulfide-isomerase 2 Protein disulfide-isomerase A6 homolog Putative alpha-L-fucosidase Putative metalloproteinase inhibitor tag-225 SERPIN domain-containing protein SERPIN domain-containing protein SPARC Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serine or cysteine protease inhibitor Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Serpin domain-containing protein Sulfhydryl oxidase Thioredoxin domain-containing protein Transmembrane protein 132 homolog VWFA domain-containing protein	A9Z1L1 G5EBH7 G5EBY8 G5EC87 G5ECM9 G5ECY2 G5EE40 G5EEF1 G5EEL5 G5EFD9 G5EFH4 G5EFX3 H2FLL2 H2KZY5 H2L2L3 O17365 O45520 P34714 P49713 P50605 P91189 P92172 Q09EE8 Q10651 Q11067 Q11186 Q17770 Q17967 Q18048 Q18096 Q18287 Q18948 Q19651 Q20684 Q21265 Q21267 Q22235 Q8MQ51 Q8WQF7 Q8WQF8 Q93791 Q9BL47 Q9N5Z7 Q9XTW2 Q9XVQ1	B0524.2 C16E9.1 C18E9.7 C28G1.2 CELE_D1054.1 CELE_F07F6.7 CELE_F07F6.8 CELE_F15D3.4 CELE_F44G3.7 CELE_F47B7.2 CELE_M04D5.1 CELE_W01A8.8 CELE_Y64G10A.7 CELE_ZK1307.8 W03G11.3 Y71H2AM.10 anoh-2 apl-1 atgl-1 calu-1 cet-1 cpi-2 daf-7 dbl-1 dnj-7 egl-17 enpl-1 famk-1 lec-2 nid-1 nucb-1 ost-1 pdi-1 pdi-2 pdi-6 sdn-1 sparc srp-1 srp-2 srp-3 srp-6 srp-7 srp-8 sup-17 tag-225 tag-320 timp-1 unc-129	Caenorhabditis elegans

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