GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **128** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID ▼
GDP-fucose biosynthesis	Fucokinase Fucose-1-phosphate guanylyltransferase GDP-L-fucose synthase GDP-fucose transporter 1 GDP-mannose 4,6 dehydratase	Q1ZXF7 Q54NH4 Q550W6 Q55C77 Q55DE9	DDB_G0269678 fpgt fuct1 ger gmd slc35c1	Dictyostelium discoideum	G85196CF
Reactions specific to the complex N-glycan synthesis pathway	Alpha-L-fucosidase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase alpha-L-fucosidase	P10901 Q54BB7 Q54L56 Q54P60 Q54PH9 Q54PJ9 Q54PK0 Q54PK3 Q54RA6 Q551C1 Q55FA8 Q86J24	DDB_G0276661 alfA fut1 fut10 fut11 fut2 fut3 fut4 fut5 fut6 fut7 fut9	Dictyostelium discoideum	G82576YO
Lewis blood group biosynthesis	Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase Fucosyltransferase WD40 repeat-containing protein	Q54BB7 Q54L56 Q54P60 Q54PH9 Q54PJ9 Q54PK0 Q54PK3 Q54RA6 Q55C63 Q55FA8 Q86J24	DDB_G0270208 fut1 fut10 fut11 fut2 fut3 fut4 fut5 fut6 fut7 fut9	Dictyostelium discoideum	G81971FM G90387AM G98173LG
Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2	alpha-1,2-Mannosidase alpha-1,2-Mannosidase alpha-1,2-Mannosidase alpha-1,2-Mannosidase alpha-1,2-Mannosidase	Q54CH4 Q54PP9 Q54PQ0 Q54PQ1 Q55EU0	DDB_G0268754 DDB_G0284391 DDB_G0284393 DDB_G0284395 DDB_G0292918	Dictyostelium discoideum	G70323CJ
Lactose synthesis	Calmodulin-binding protein Sugar transporter family protein	Q54CM5 Q54Z55	DDB_G0277773 symA	Dictyostelium discoideum	G58161NS
Glycogen breakdown (glycogenolysis)	Glycogen debranching enzyme Glycogen phosphorylase 1 Glycogen phosphorylase 2 Maltase Phosphoglucomutase-1 Uncharacterized protein	P34114 Q00766 Q23919 Q54K94 Q54L24 Q55D50	agl gaa glpD glpV gtr3 pgmA	Dictyostelium discoideum	G58161NS
Regulation of insulin secretion	Calmodulin-binding protein Sugar transporter family protein	Q54CM5 Q54Z55	DDB_G0277773 symA	Dictyostelium discoideum	G58161NS
Fructose biosynthesis	Aldose reductase B	Q54NZ7	alrB	Dictyostelium discoideum	G58161NS
Cellular hexose transport	Calmodulin-binding protein Major facilitator superfamily (MFS) profile domain-containing protein Sugar transporter SWEET1 Sugar transporter family protein Sugar transporter family protein Uncharacterized protein	Q54CM5 Q54JW5 Q54M69 Q54UC8 Q54Z55 Q7KWK4	DDB_G0276801 DDB_G0277773 DDB_G0281155 DDB_G0286151 slc50a1 symA	Dictyostelium discoideum	G58161NS
Glycolysis	Enolase A Enolase B Fructose-bisphosphate aldolase Glucosamine-6-phosphate isomerase Glucose-6-phosphate isomerase Glyceraldehyde-3-phosphate dehydrogenase Phosphoglycerate kinase Probable phosphoglucomutase-2 Probable phosphoglycerate mutase Pyruvate kinase Triosephosphate isomerase Uncharacterized protein	Q54K22 Q54NE6 Q54RF5 Q54RK5 Q54UQ2 Q54XK9 Q55F83 Q5V9E9 Q869R8 Q86A67 Q94469 Q9GPM4	enoA enoB fba g6pi glk gniA gnpda1 gpdA gpi gpmA nagB2 pgam pgi pgkA pgmB pyk tpiA	Dictyostelium discoideum	G58161NS
Digestion of dietary carbohydrate	Maltase	Q55D50	gaa	Dictyostelium discoideum	G58161NS G96370VA
Intestinal hexose absorption	Calmodulin-binding protein Sugar transporter family protein	Q54CM5 Q54Z55	DDB_G0277773 symA	Dictyostelium discoideum	G58161NS G93924TT
Antimicrobial peptides	Transglycosylase SLT domain-containing protein UPF0522 protein C	Q54XV8 Q55BA2	DDB_G0271242 DDB_G0278563	Dictyostelium discoideum	G49108TO
Hyaluronan uptake and degradation	Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 beta-N-acetylhexosaminidase	P13723 Q54K55 Q54K56 Q54MU9 Q54SC9	hexa1 hexa2 hexb1 hexb2 nagA nagE	Dictyostelium discoideum	G35674CY
Hyaluronan biosynthesis and export	Protein DDB_G0287365 Transmembrane protein	Q54KF6 Q55D62	DDB_G0270636 DDB_G0287365	Dictyostelium discoideum	G35674CY
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating Glucose-6-phosphate 1-dehydrogenase Probable 6-phosphogluconolactonase Probable phosphoglucomutase-2 Probable transaldolase Ribokinase Ribose-5-phosphate isomerase Ribulose-phosphate 3-epimerase	Q54CJ3 Q54UP4 Q54UQ2 Q54UQ4 Q54YE7 Q551C2 Q557D2 Q8TA03	PGD g6pd-1 g6pd-2 gnd pgl pgls pgmB rbsk rpe rpiA tal zwf	Dictyostelium discoideum	G31080DL
CS/DS degradation	Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 Beta-xylosidase-like protein beta-N-acetylhexosaminidase	P13723 Q54J53 Q54K55 Q54K56 Q54MU9 Q54SC9	DDB_G0288289 hexa1 hexa2 hexb1 hexb2 nagA nagE	Dictyostelium discoideum	G27025MB
Glycosphingolipid catabolism	Alpha-galactosidase Beta-galactosidase 1 Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 Glucosylceramidase Neutral ceramidase A Probable alpha-galactosidase Saposin A Sphingomyelin phosphodiesterase A Sphingomyelin phosphodiesterase B Sphingomyelinase DDB_G0288017 Type I phosphodiesterase/nucleotide pyrophosphatase family protein Uncharacterized protein DDB_G0272682 beta-N-acetylhexosaminidase	P13723 Q1ZXD9 Q54BK2 Q54C16 Q54D71 Q54EG4 Q54GE1 Q54K55 Q54K56 Q54MJ8 Q54MU9 Q54Q68 Q54SC9 Q55B10 Q55C09 Q86IG2	DDB_G0272682 DDB_G0285897 DDB_G0288017 DDB_G0291524 DDB_G0292446 dcd dcd2A glb1 hexa1 hexa2 hexb1 hexb2 melA nagA nagE rsc25 sapA sgmA sgmB	Dictyostelium discoideum	G09546QO G27025MB G58161NS
Keratan sulfate degradation	Beta-galactosidase 1 Beta-hexosaminidase subunit A1 Beta-hexosaminidase subunit A2 Beta-hexosaminidase subunit B1 Beta-hexosaminidase subunit B2 beta-N-acetylhexosaminidase	P13723 Q54GE1 Q54K55 Q54K56 Q54MU9 Q54SC9	glb1 hexa1 hexa2 hexb1 hexb2 nagA nagE	Dictyostelium discoideum	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 Q54CI0 Q55G89	DDB_G0268520 ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum	G03934XO G25577BM G28233ME G51034LA G86419OL
HS-GAG degradation	Alpha-N-acetylglucosaminidase Beta-galactosidase 1 Beta-xylosidase-like protein	Q54DW5 Q54GE1 Q54J53	DDB_G0288289 glb1 naglu	Dictyostelium discoideum	G01550VL G09546QO
Lysosomal oligosaccharide catabolism	Alpha-mannosidase B Alpha-mannosidase C Alpha-mannosidase D Alpha-mannosidase E Alpha-mannosidase F Alpha-mannosidase G Lysosomal alpha-mannosidase beta-mannosidase	P34098 Q1ZXI8 Q54K67 Q54KN4 Q54YC4 Q54YF7 Q552S3 Q55ER0	DDB_G0275917 manA manB manC manD manE manF manG	Dictyostelium discoideum	G00027MO G25577BM G28233ME G70323CJ G90333CG
Atorvastatin ADME	ABC transporter B family member 2 ABC transporter B family member 3 ABC transporter B family member 6 ABC transporter B family member 7 ABC transporter C family member 10 ABC transporter C family member 12 ABC transporter C family member 3 ABC transporter C family member 5 ABC transporter C family member 8 Glycosyl transferase family 28 C-terminal domain-containing protein Glycosyltransferase family 28 N-terminal domain-containing protein Glycosyltransferase family 28 N-terminal domain-containing protein Serine protease/ABC transporter B family protein tagA Serine protease/ABC transporter B family protein tagB Serine protease/ABC transporter B family protein tagC Serine protease/ABC transporter B family protein tagD	P54683 Q23868 Q54BT3 Q54JR2 Q54LE6 Q54P13 Q54RU1 Q54U44 Q55DA7 Q55FB2 Q55FX8 Q55FY0 Q8ST87 Q8T9W1 Q8T9W4 Q9GTN7	DDB_G0268184 abcB2 abcB3 abcB6 abcB7 abcC10 abcC12 abcC3 abcC5 abcC8 tagA tagB tagC tagD ugt2 ugt3	Dictyostelium discoideum
Mitochondrial ABC transporters	ABC transporter B family member 2 ABC transporter B family member 3 ABC transporter B family member 5 ABC transporter B family member 6 ABC transporter B family member 7 Serine protease/ABC transporter B family protein tagA Serine protease/ABC transporter B family protein tagB Serine protease/ABC transporter B family protein tagC Serine protease/ABC transporter B family protein tagD	P54683 Q23868 Q54BT3 Q54RU1 Q55DA7 Q8T9W1 Q8T9W2 Q8T9W4 Q9GTN7	abcB2 abcB3 abcB5 abcB6 abcB7 tagA tagB tagC tagD	Dictyostelium discoideum
Peroxisomal protein import	2-Hydroxyacid oxidase 2-hydroxyacyl-CoA lyase 1 AB hydrolase-1 domain-containing protein Acyl-coenzyme A oxidase Catalase-A D-amino-acid oxidase Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial E2 ubiquitin-conjugating enzyme FAD dependent oxidoreductase domain-containing protein Insulin-degrading enzyme homolog Isocitrate dehydrogenase [NADP], mitochondrial Malonyl-CoA decarboxylase C-terminal domain-containing protein NADPH--cytochrome P450 reductase Nudix hydrolase domain-containing protein PXMP2/4 family protein 1 Peroxisomal acyl-coenzyme A oxidase 1 Peroxisomal membrane protein PEX13 Peroxisomal membrane protein PEX14 Peroxisomal targeting signal 1 receptor Peroxisomal targeting signal 2 receptor Peroxisome biogenesis factor 10 Phytanoyl-CoA dioxygenase Polyubiquitin-F Polyubiquitin-G Polyubiquitin-H Polyubiquitin-I Polyubiquitin-J Probable enoyl-CoA hydratase 2 Putative peroxisome assembly protein 12 Serine--pyruvate aminotransferase Ubiquitin conjugating enzyme E2 B Ubiquitin-like domain-containing protein Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein Uncharacterized protein acetyl-CoA C-acyltransferase hydroxymethylglutaryl-CoA lyase ubiquitinyl hydrolase 1	O77229 P0CG78 P0CG79 P0CG80 P0CG81 P0CG88 P14794 P14797 Q54C55 Q54CI0 Q54CL3 Q54DA9 Q54E41 Q54FX4 Q54GC2 Q54GK8 Q54GQ6 Q54GT6 Q54JQ2 Q54MD1 Q54N40 Q54QI7 Q54S31 Q54SF6 Q54SS0 Q54US8 Q54WA3 Q54XC3 Q54XZ0 Q54ZX5 Q553T4 Q556W1 Q55CT1 Q55FN8 Q75JR2 Q86IY4 Q8MMS1 Q94490	DDB_G0268018 DDB_G0274339 DDB_G0275415 DDB_G0277335 DDB_G0277477 DDB_G0279049 DDB_G0280851 DDB_G0282495 DDB_G0287851 DDB_G0290089 DDB_G0290277 DDB_G0290547 acox1 agxt cat catA ddo-1 ddo-2 ech1 hacl1 haox hmgL idhM mfe2 mfeB pex10 pex12 pex13 pex14 pex5 pex7 redB ubcB ubqB ubqC ubqF ubqG ubqH ubqI ubqJ ubqO veg116	Dictyostelium discoideum

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