GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **226 - 250** of **270** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID ▲
Insulin receptor signalling cascade	Growth factor receptor bound protein 10 Growth factor receptor-bound protein 2 Insulin SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein kinase receptor	A0A1D5NYP8 A0A1D5P405 A0A1D5P6T3 A0A1D5PEZ2 A3R0S3 P67970	GRB10 GRB2 INS INSR SHC1 SOS1	Gallus gallus (chicken)
Creation of classical C3 convertase	Complement 4 Complement C1q B chain Complement C1q subcomponent subunit A Complement C1s subcomponent Complement factor B-like protease (Fragment) Ig lambda chain C region Ig lambda chain V-1 region Ig mu chain C region MAp19 MHC-linked complement C4 Mannan-binding lectin associated serine protease 2 Mannan-binding lectin associated serine protease 3 Mannose-binding protein VH1 protein (Fragment) complement subcomponent C1r	A0A3Q2UG72 A0A8V0Z078 A2N884 F1NAB7 F1NH19 P01875 P04210 P20763 P81475 Q076D6 Q5F3N3 Q6Q1Q7 Q6Q1Q8 Q6Q1Q9 Q98TA4	C1QA C1QB C1R C4 C4-2 MASP2 MBL RCJMB04_11h6 VH1	Gallus gallus (chicken)
RET signaling	Docking protein 1 Fibroblast growth factor receptor substrate 2 GDNF family receptor alpha-1 Growth factor receptor bound protein 10 Growth factor receptor-bound protein 2 PDZ and LIM domain protein 7 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Protein kinase C Proto-oncogene tyrosine-protein kinase Src SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 Tyrosine-protein phosphatase non-receptor type 11 phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A0E4BA89 A0A1D5NYP8 A0A1D5P405 A0A1D5PEZ2 A0A1D5PZ39 A0A3Q3ACS4 A3R0S3 E1C021 E1C2C5 F1NHX1 O13156 P00523 Q5F4A2 Q90687 R4GHL2	DOK1 FRS2 GDNFRA GFRA1 GRB10 GRB2 PDLIM7 PIK3CB PIK3CD PIK3R1 PIK3R2 PRKCA PTPN11 SHC1 SOS1 SRC	Gallus gallus (chicken)
MET activates PTK2 signaling	Focal adhesion kinase 1 Proto-oncogene tyrosine-protein kinase Src	P00523 Q00944	FAK FAK1 PTK2 SRC	Gallus gallus (chicken)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	GTP-binding protein Par-6 family cell polarity regulator alpha Polyubiquitin-B Protein kinase C TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P546 E1BQN6 F1P0U8 H9CX01 O93467 P0CG62 P79781 Q06900 Q90999	ChALK5 PARD6A PRKCZ RHOA RPS27A TGFB1 TGFBR1 TGFBR2 UBA80 UBB cRhoA rhoA	Gallus gallus (chicken)
Arachidonate metabolism	Cytosolic phospholipase A2	P49147	CPLA2 PLA2G4 PLA2G4A	Gallus gallus (chicken)
TLR15 cascade	Toll-like receptor 2	Q2XQ10	TLR15	Gallus gallus (chicken)
Voltage gated Potassium channels	A-type voltage-gated potassium channel KCND2 Potassium voltage-gated channel modifier subfamily F member 1 Potassium voltage-gated channel modifier subfamily G member 1 Potassium voltage-gated channel modifier subfamily G member 4 Potassium voltage-gated channel modifier subfamily S member 2 Potassium voltage-gated channel modifier subfamily S member 3 Potassium voltage-gated channel subfamily A member 10 Potassium voltage-gated channel subfamily A member 2 Potassium voltage-gated channel subfamily A member 3 Potassium voltage-gated channel subfamily A member 4 Potassium voltage-gated channel subfamily B member 1 Potassium voltage-gated channel subfamily B member 2 Potassium voltage-gated channel subfamily C member 4 Potassium voltage-gated channel subfamily D member 3 Potassium voltage-gated channel subfamily H member 1 Potassium voltage-gated channel subfamily H member 8 Potassium voltage-gated channel subfamily Q member 5 Potassium voltage-gated channel subfamily V member 1 Voltage-gated potassium channel regulatory subunit KCNG2 Voltage-gated potassium channel subunit beta-1	A0A1D5P1M1 A0A1D5P7T5 A0A1D5PA94 A0A1D5PCF8 A0A1D5PI60 A0A1D5PI98 E1BQU8 E1BS72 E1BWF1 E1BYX3 E1C3M8 E1C3U8 F1NK95 F1NRL8 F1P320 O73606 Q7T199 Q7T1A0 Q9PWR1 Q9YGX8	KCNA10 KCNA2 KCNA3 KCNA4 KCNAB1 KCNB1 KCNB2 KCNC4 KCND2 KCND3 KCNF1 KCNG1 KCNG2 KCNG4 KCNH1 KCNH8 KCNQ5 KCNS2 KCNS3 KCNV1 KVB1.1	Gallus gallus (chicken)
Norepinephrine Neurotransmitter Release Cycle	Complexin-1 Synaptosomal-associated protein 25 Synaptotagmin-1 Syntaxin-binding protein 1 Unc-13 homolog B	A0A1D5PHU2 E1C8G7 F1NY18 P47191 P60878	CPLX1 SNAP SNAP25 STXBP1 SYT1 UNC13B	Gallus gallus (chicken)
Signaling by EGFR	Amphiregulin Angio associated migratory cell protein Betacellulin Epigen Epiregulin Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Receptor protein-tyrosine kinase	A0A1D5PKH0 F1NJR9 P00523 Q5EG71 Q5ZLQ3 Q645M5 Q64EU6 Q9W7C5	AAMP AREG BTC EGFR EPGN EREG HBEGF HEGFL SRC	Gallus gallus (chicken)
SHC-mediated cascade:FGFR3	Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor 3 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 SHC-transforming protein 1 SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A1D5NYP8 A0A1D5PEZ2 A0A1D5PT95 A3R0S3 E1BZW7 P08642 P18460 P19596 P48800 Q197G3 Q4R0X9 Q5F352 Q9I950 R4GIR0	CEK2 FGF-18 FGF1 FGF18 FGF2 FGF23 FGF4 FGF8 FGFR3 Fgf16 GRB2 HRAS HRAS1 KRAS NRAS SHC1 SOS1	Gallus gallus (chicken)
Lysosomal oligosaccharide catabolism				Gallus gallus (chicken)	G00027MO G25577BM G28233ME G70323CJ G90333CG
HS-GAG degradation	Alpha-L-iduronidase Glucuronidase beta Glypican-1 Syndecan-4 Syndecan Syndecan	A0A1L1RSD2 F1NV24 F1P150 P49416 Q5F366 Q8JIY0	GPC1 GUSB RCJMB04_31l23 SDC1 SDC2 SDC4	Gallus gallus (chicken)	G01550VL G09546QO
N-glycan trimming in the ER and Calnexin/Calreticulin cycle	Autocrine motility factor receptor Polyubiquitin-B Transitional endoplasmic reticulum ATPase Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P546 F1NBB7 P0CG62 P79781 Q5ZMU9	AMFR RPS27A UBA80 UBB VCP vcp	Gallus gallus (chicken)	G03934XO G25577BM G28233ME G51034LA G86419OL
Keratan sulfate degradation	Beta-hexosaminidase Fibromodulin Keratocan Lumican Mimecan N-acetylglucosamine-6-sulfatase	A0A1D5NTY7 F1NI04 F1NTQ2 O42235 P51890 Q9W6H0	FMOD GNS HEXB KERA LDC LUM OGN	Gallus gallus (chicken)	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB G85384LV
Glycosphingolipid catabolism	Acid ceramidase Beta-hexosaminidase Mannose-6-phosphate receptor, cation dependent Sulfatase N-terminal domain-containing protein exo-alpha-sialidase sphingomyelin phosphodiesterase	A0A1D5PL80 A0A1L1RMY8 A0A3Q2TVY6 E1BYN0 F1NTQ2 R4GH41	ASAH1 HEXB LOC418658 M6PR NEU2 SMPD2	Gallus gallus (chicken)	G09546QO G27025MB G58161NS
CS/DS degradation	Alpha-L-iduronidase Beta-hexosaminidase Decorin	A0A1L1RX77 F1NTQ2 Q5F366	DCN HEXB RCJMB04_31l23	Gallus gallus (chicken)	G27025MB
Pentose phosphate pathway	6-phosphogluconate dehydrogenase, decarboxylating 6-phosphogluconolactonase Ribokinase Transaldolase Transketolase	A0A1D5PC23 F1N8A7 F1P1A5 Q5ZIZ0 Q5ZJY1	RBKS RCJMB04_14h20 RCJMB04_22k15 TALDO1 TKTL1	Gallus gallus (chicken)	G31080DL
Hyaluronan biosynthesis and export	Hyaluronan synthase 3	O57425	HAS3	Gallus gallus (chicken)	G35674CY
Hyaluronan uptake and degradation	Beta-hexosaminidase Calcineurin B homologous protein 1 Glucuronidase beta Lymphatic vessel endothelial hyaluronan receptor 1	A0A1L1RSD2 E1C9I1 F1NTQ2 Q5ZM44	CHP CHP1 GUSB HEXB LYVE1	Gallus gallus (chicken)	G35674CY
Initial triggering of complement	Collectin-10 Collectin-11 Complement C1q B chain Complement C1q C chain Mannose-binding protein Uncharacterized protein complement subcomponent C1r	A0A1D5PGB2 A0A1D5PIR0 A0A3Q3A736 F1NAB7 F1NH19 Q2LK95 Q98TA4	C1QB C1QC C1R CL1 COLEC10 COLEC11 MBL	Gallus gallus (chicken)	G49108TO G57321FI
Lectin pathway of complement activation	Collectin-10 Collectin-11 Mannose-binding protein	A0A3Q3A736 Q2LK95 Q98TA4	CL1 COLEC10 COLEC11 MBL	Gallus gallus (chicken)	G49108TO G57321FI
Ficolins bind to repetitive carbohydrate structures on the target cell surface				Gallus gallus (chicken)	G49108TO G57321FI
Antimicrobial peptides	Angiogenin Cathelicidin B1 Cathelicidin-1 Cathelicidin-2 Cathelicidin-3 Chromogranin-A Liver ribonuclease A Lysozyme C NK-lysin Ribonuclease homolog	F1NLZ2 P00698 P27043 P30374 Q2I811 Q2IAL6 Q2IAL7 Q5GAL6 Q6QLQ5 R4GJF1	ANG CATH CATHB1 CATHL1 CATHL2 CATHL3 CHGA CL2 CMAP27 GNLY LYZ	Gallus gallus (chicken)	G49108TO
Cellular hexose transport	Solute carrier family 2 member 11 Solute carrier family 2 member 5 Solute carrier family 2 member 8 Solute carrier family 2, facilitated glucose transporter member 12 Solute carrier family 2, facilitated glucose transporter member 3	E1C4E5 F1NDA6 F1NTJ1 F1NVV4 F1P4J7	SLC2A11 SLC2A12 SLC2A14 SLC2A5 SLC2A8	Gallus gallus (chicken)	G58161NS G70323CJ

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