GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **151 - 175** of **263** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol ▼	Organism	GlyTouCan ID
Interferon gamma signaling	Interferon gamma receptor 2 (interferon gamma transducer 1) Interferon gamma Protein kinase C delta type Signal transducer and activator of transcription Suppressor of cytokine signaling 1 Suppressor of cytokine signaling 3 Tyrosine-protein kinase calcium/calmodulin-dependent protein kinase	A0A1D5PS87 B6RCQ2 F1NGS8 F1NMJ9 F1P3G1 P49708 Q5ZJK3 R4GJH9	CAMK2A IFNG IFNGR2 JAK1 PRKCD RCJMB04_17i9 SOCS1 SOCS3	Gallus gallus (chicken)
Ca2+ pathway	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase Catenin beta-1 Frizzled class receptor 3 Frizzled-4 G protein subunit alpha transducin 2 G protein subunit beta 3 G protein subunit beta 4 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein G(o) subunit alpha Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Lymphoid enhancer binding factor 1 Phosphodiesterase Protein Wnt-11 Protein Wnt Protein phospatase 3 regulatory subunit B alpha isoform type 1 Rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma calcium/calmodulin-dependent protein kinase small monomeric GTPase	A0A1D5NTJ0 A0A1D5NYE8 A0A1D5NZL7 A0A1D5P7Z5 A0A1D5PLZ8 A0A1D5PT95 A0A1D5PZ45 A0A3Q2UEZ9 A0A3Q3B1W2 E1BW98 E1C1U6 E1C795 F1NA42 F1NGS8 F1NLV4 P49339 Q5ZJ03 Q6VN51 Q802E4 Q9IA05 Q9YGX6 R4GFT9 R4GKD1	CAMK2A CTNNB1 FZ4 FZD3 FZD4 GNAO1 GNAT2 GNB1 GNB3 GNB4 GNG10 GNG12 GNG13 GNG2 GNG5 GNGT2 KRAS LEF1 OXLD1 PDE6B PDE6b PLCB1 RCJMB04_23k16 WNT-11 WNT11 WNT5A	Gallus gallus (chicken)
Regulation of insulin secretion	ATP-sensitive inward rectifier potassium channel 11 Rap guanine nucleotide exchange factor 4 Voltage-dependent L-type calcium channel subunit alpha-1D Voltage-dependent L-type calcium channel subunit beta-2 Voltage-dependent L-type calcium channel subunit beta-3 cAMP-dependent protein kinase	A0A1D5PMC0 A0A3Q3AHR0 E1BZF6 F1NBC9 O73700 R4GIN8	CACNA1D CACNB2 KCNJ11 LOC107050029 PRKACB RAPGEF4	Gallus gallus (chicken)	G58161NS
Complement Cascade	Complement 4 Complement C3 Complement C5 Complement factor B-like protease (Fragment) Complement regulatory GPI-anchor protein Complement regulatory membrane protein MHC-linked complement C4	A0A3Q2UG72 A0A8V1AM71 P81475 Q076D6 Q4AEI5 Q90633 Q9DEG0	C4 C4-2 C5 CREG Cremp	Gallus gallus (chicken)
Initial triggering of complement	Collectin-10 Collectin-11 Complement C1q B chain Complement C1q C chain Mannose-binding protein Uncharacterized protein complement subcomponent C1r	A0A1D5PGB2 A0A1D5PIR0 A0A3Q3A736 F1NAB7 F1NH19 Q2LK95 Q98TA4	C1QB C1QC C1R CL1 COLEC10 COLEC11 MBL	Gallus gallus (chicken)	G49108TO G57321FI
Creation of classical C3 convertase	Complement 4 Complement C1q B chain Complement C1q subcomponent subunit A Complement C1s subcomponent Complement factor B-like protease (Fragment) Ig lambda chain C region Ig lambda chain V-1 region Ig mu chain C region MAp19 MHC-linked complement C4 Mannan-binding lectin associated serine protease 2 Mannan-binding lectin associated serine protease 3 Mannose-binding protein VH1 protein (Fragment) complement subcomponent C1r	A0A3Q2UG72 A0A8V0Z078 A2N884 F1NAB7 F1NH19 P01875 P04210 P20763 P81475 Q076D6 Q5F3N3 Q6Q1Q7 Q6Q1Q8 Q6Q1Q9 Q98TA4	C1QA C1QB C1R C4 C4-2 MASP2 MBL RCJMB04_11h6 VH1	Gallus gallus (chicken)
Nicotinate metabolism	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase NAD(+) kinase Nicotinamide-nucleotide adenylyltransferase Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2	A0A1D5NZW2 A0A1D5PVT8 A0A1L1RQU5 E1BXJ1 E5G6H7	BST1 CD38 NADK NMNAT1 NMNAT2	Gallus gallus (chicken)
Proton-coupled monocarboxylate transport	Basigin Monocarboxylate transporter 1 Monocarboxylate transporter 2	F1NVU4 P17790 Q5ZLZ6	BSG RCJMB04_4e8 SLC16A7	Gallus gallus (chicken)
Integrin cell surface interactions	Basigin Collagen type IV alpha 1 chain Fibronectin Integrin alpha-6 Integrin beta Integrin subunit alpha 4 Integrin subunit alpha 9 Leukocyte surface antigen CD47 Lumican	A0A1D5P8P3 A0A1D5PKL9 A0A1D5PQP8 P11722 P17790 P26007 P51890 Q6XFR1 Q92071	BSG CD47 COL4A1 FN1 ITGA4 ITGA6 ITGA9 ITGB3 LDC LUM	Gallus gallus (chicken)
MAP2K and MAPK activation	14-3-3 protein beta/alpha Dual specificity mitogen-activated protein kinase kinase 1 Fibronectin GTPase HRas GTPase NRas IQ motif containing GTPase activating protein 1 Integrin beta Kinase suppressor of ras 2 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein Rap-1b Serine/threonine-protein kinase B-raf Vinculin small monomeric GTPase small monomeric GTPase	A0A1D5PIZ8 A0A1D5PT95 A0A1D5PX90 F1NSA8 P00523 P05625 P08642 P11722 P12003 Q04982 Q5F352 Q5ZHX1 Q5ZIF0 Q5ZLQ6 Q92071	BRAF FN1 HRAS HRAS1 IQGAP3 ITGB3 KRAS KSR2 MIL NRAS RAF1 RAP1A RAP1B RCJMB04_27f19 RMIL SRC VCL VINC1 YWHAB	Gallus gallus (chicken)
Collagen chain trimerization	Collagen alpha-1(XVII) chain Collagen type I alpha 1 chain Collagen type I alpha 2 chain Collagen type III alpha 1 chain Collagen type XII alpha 1 chain	A0A1D5PE57 A0A1D5PYU1 A0A1L1RPW4 A0A5H1ZRJ7 Q90584	BP180 BPAG2 COL12A1 COL17A1 COL1A1 COL1A2 COL3A1	Gallus gallus (chicken)
Myogenesis	BCL2 interacting protein 2 Cadherin-2 Catenin beta-1 Cell division control protein 42 homolog Mitogen-activated protein kinase 12 Myocyte enhancer factor 2D Myogenic factor 6 Myogenic factor Myogenic factor Myogenin mitogen-activated protein kinase	A0A1D5NYE8 A0A1D5NYL4 A0A1D5PIQ5 F1NEC1 F1NHM3 F1NLU9 P10288 P17920 Q01795 Q90694 R4GMI9	BNIP2 CDC42 CDH2 CTNNB1 MAPK12 MAPK14 MEF2D MRF4 MYF5 MYF6 MYOD1 MYOG	Gallus gallus (chicken)
Oxidative Stress Induced Senescence	Cyclin dependent kinase 6 Cyclin dependent kinase inhibitor 2B Cyclin dependent kinase inhibitor 2C E3 ubiquitin-protein ligase RING2 Histone H2A-IV Histone H2A.J Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2/3/4/6 Histone H2B 5 Histone H2B 7 Histone H2B 8 Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 MAPK activated protein kinase 2 MAPK activated protein kinase 3 Mitogen-activated protein kinase 9 Polycomb complex protein BMI-1 Polycomb protein EED Protein c-Fos RB binding protein 4, chromatin remodeling factor Stress-activated protein kinase JNK Thioredoxin mitogen-activated protein kinase kinase kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase kinase mitogen-activated protein kinase	A0A1D5NVP0 A0A1D5P1F4 A0A1D5PD64 A0A1D5PIQ5 A0A1D5PTJ8 A0A1D5PY49 A0A1L1RNY8 A0A3Q2TY19 A0A3Q2U1E9 A0A3Q2UDI2 F1NCY7 F1NDD7 F1NLF9 F1P5G5 F2Z4M0 P02263 P02272 P08629 P0C1H3 P0C1H4 P0C1H5 P11939 P62801 P70082 P79996 P84229 P84247 Q5SDR3 Q5ZKH3 Q7ZT27 Q90771 Q9PSW9	BMI1 CDK6 CDKN2B CDKN2C EED FOS H2A-IX H2AF H2AFX H2AZ2 H2B-I H2B-II H2B-III H2B-IV H2B-V H2B-VI H2B-VII H2B-VIII H3-I H3-II H3-III H3-IV H3-IX H3-V H3-VI H3-VII H3-VIII H3-X H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII HIST1H2B5L JNK2 LOC100859381 LOC426037 MAP2K3 MAP2K4 MAP3K5 MAPK14 MAPK8 MAPK9 MAPKAPK2 MAPKAPK3 PCGF4 RBBP4 RNF2 TXN cdk6	Gallus gallus (chicken)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	Coagulation factor X Osteocalcin	A0A1D5PRL0 P25155	BGLAP F10 FX	Gallus gallus (chicken)
Removal of aminoterminal propeptides from gamma-carboxylated proteins	Coagulation factor X Osteocalcin furin	A0A1D5PRL0 P25155 Q91000	BGLAP F10 FURIN FX	Gallus gallus (chicken)
Activated NTRK2 signals through PLCG1	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor	P25429 Q91987	BDNF NTRK2 TRKB	Gallus gallus (chicken)
NTRK2 activates RAC1	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor Ras-related C3 botulinum toxin substrate 1 Tyrosine-protein kinase	A0A3Q2U639 P25429 Q6LC82 Q91987	BDNF FYN NTRK2 TRKB cRac1A	Gallus gallus (chicken)
Activated NTRK2 signals through FRS2 and FRS3	BDNF/NT-3 growth factors receptor Brain-derived neurotrophic factor Fibroblast growth factor receptor substrate 2 Growth factor receptor-bound protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1	A0A1D5PEZ2 A3R0S3 E1C021 P25429 Q91987	BDNF FRS2 GRB2 NTRK2 SOS1 TRKB	Gallus gallus (chicken)
Formation of the beta-catenin:TCF transactivating complex	BCL9 transcription coactivator Catenin beta-1 Histone H2A-IV Histone H2A.J Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2/3/4/6 Histone H2B 5 Histone H2B 7 Histone H2B 8 Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Histone deacetylase 1 Lymphoid enhancer binding factor 1 Parafibromin Pygopus family PHD finger 1 RB binding protein 5, histone lysine methyltransferase complex subunit RuvB-like helicase TLE family member 1, transcriptional corepressor TLE family member 3, transcriptional corepressor Transcription factor 7 (T-cell specific, HMG-box) Uncharacterized protein	A0A1D5NYE8 A0A1D5P5C3 A0A1D5PQ44 A0A1D5PY49 A0A1L1RNY8 A0A3Q2TTV3 A0A3Q2UDI2 A0A3Q3B1W2 E1BWE1 F1N8Z4 F1NDB6 F1NDD7 F1P5G5 P02263 P02272 P0C1H3 P0C1H4 P0C1H5 P56517 P62801 P70082 P84229 P84247 Q5ZIL1 Q5ZLM0 Q5ZLX3 Q9PSW9	BCL9 CDC73 CTNNB1 H2A-IX H2AF H2AFX H2AZ2 H2B-I H2B-II H2B-III H2B-IV H2B-V H2B-VI H2B-VII H2B-VIII H3-I H3-II H3-III H3-IV H3-IX H3-V H3-VI H3-VII H3-VIII H3-X H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII HDAC1 HDAC1A HIST1H2B5L LEF1 LOC100859381 LOC426037 PYGO1 RBBP5 RCJMB04_25e24 RUVBL1 TCF7 TLE1 TLE3	Gallus gallus (chicken)
Downregulation of TGF-beta receptor signaling	BMP and activin membrane-bound inhibitor homolog E3 ubiquitin-protein ligase CHIP Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Polyubiquitin-B Prostate transmembrane protein, androgen induced 1 Serine-threonine kinase receptor-associated protein TGF-beta receptor type-1 TGF-beta receptor type-2 Transforming growth factor beta Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5NUH3 A0A1D5P546 A0A1D5PNY8 E1AWU3 H9CX01 P0CG62 P79781 P84023 Q06900 Q5ZHY5 Q5ZJ16 Q5ZL33 Q8UWF3 Q90999	BAMBI ChALK5 LOC769000 MADH2 MADH3 PMEPA1 RPS27A SMAD3 SMAD7 STRAP STUB1 TGFB1 TGFBR1 TGFBR2 UBA80 UBB	Gallus gallus (chicken)
VEGFA-VEGFR2 Pathway	Adapter molecule crk Brain-specific angiogenesis inhibitor 1-associated protein 2 Cell division control protein 42 homolog Cytochrome b-245 light chain Cytoplasmic FMR1-interacting protein Cytoplasmic FMR1-interacting protein Cytoplasmic protein Engulfment and cell motility 2 Focal adhesion kinase 1 GDP/GTP exchange factor VAV3 GTP-binding protein Integrin beta MAPK activated protein kinase 2 MAPK activated protein kinase 3 Mitogen-activated protein kinase 12 Nck-associated protein 1 Neutrophil cytosolic factor 4 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphoinositide-3-kinase regulatory subunit 2 Proto-oncogene tyrosine-protein kinase Src Ras-related C3 botulinum toxin substrate 1 SH2 domain containing adaptor protein B Tyrosine-protein kinase Uncharacterized protein Vascular endothelial growth factor receptor 2 Wiskott-Aldrich syndrome protein family member mitogen-activated protein kinase non-specific serine/threonine protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A1D5NVK9 A0A1D5P0L1 A0A1D5PIQ5 A0A3Q2U1E9 A0A3Q2U639 A0A3Q2UHS2 A0A3Q2UPF3 A0A3Q3ACS4 E1BS97 E1BW56 E1C122 E1C2C5 F1NCY7 F1NE09 F1NLU9 F1NW21 F1P4Q4 O93467 P00523 Q00944 Q04929 Q5F4A2 Q5ZKT0 Q5ZL97 Q6LC82 Q8UUX6 Q90694 Q92071 R4GGM0	BAIAP2 CDC42 CRK CYFIP1 CYFIP2 ELMO2 FAK FAK1 FYN ITGB3 KDR MAPK12 MAPK14 MAPKAPK2 MAPKAPK3 NCF4 NCK1 NCKAP1 PAK2 PIK3CB PIK3R1 PIK3R2 PTK2 RCJMB04_7b13 RCJMB04_9e23 RHOA SHB SRC VAV3 WASF3 cRac1A cRhoA rhoA	Gallus gallus (chicken)
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	B-cell-activating factor BAFF CD40 ligand TNF receptor-associated factor	A0A3Q3AAA5 Q8JHJ4 Q9I8D8	BAFF CD40L CD40LG TNFSF13B TNFSF5 TRAF3	Gallus gallus (chicken)
TNFR2 non-canonical NF-kB pathway	B-cell-activating factor BAFF CD40 ligand TNF receptor superfamily member 1B TNF receptor-associated factor	A0A1D5PTU3 A0A3Q3AAA5 Q8JHJ4 Q9I8D8	BAFF CD40L CD40LG TNFRSF1B TNFSF13B TNFSF5 TRAF3	Gallus gallus (chicken)
G2/M DNA damage checkpoint	BRISC and BRCA1-A complex member 2 Histone H2A Histone H2A Histone H2A Histone H2B 1/2/3/4/6 Histone H2B 5 Histone H2B 7 Histone H2B 8 Histone H2B Histone H2B Histone H4 Protein inhibitor of activated STAT 4	A0A1D5P2D1 A0A1D5PY49 A0A1L1RNY8 A0A3Q2UDI2 F1NDD7 F1P5G5 P0C1H3 P0C1H4 P0C1H5 P62801 Q5ZML0 Q9PSW9	BABAM2 BRE H2AFX H2B-I H2B-II H2B-III H2B-IV H2B-V H2B-VI H2B-VII H2B-VIII H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII HIST1H2B5L LOC100859381 LOC426037 PIAS4	Gallus gallus (chicken)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	BRISC and BRCA1-A complex member 2 Eyes absent homolog Eyes absent homolog Eyes absent homolog Histone H2A Histone H2A Histone H2A Histone H2B 1/2/3/4/6 Histone H2B 5 Histone H2B 7 Histone H2B 8 Histone H2B Histone H2B Histone H4 Polyubiquitin-B Protein inhibitor of activated STAT 4 SUMO-conjugating enzyme UBC9 Small ubiquitin-related modifier 1 Stress-activated protein kinase JNK Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein [histone H3]-trimethyl-L-lysine(9) demethylase [histone H3]-trimethyl-L-lysine(9) demethylase	A0A1D5NXI7 A0A1D5P2D1 A0A1D5P546 A0A1D5PC43 A0A1D5PGP0 A0A1D5PY49 A0A1L1RNY8 A0A3Q2TSH5 A0A3Q2TY19 A0A3Q2UDI2 E1C6D5 F1NDD7 F1P5G5 P0C1H3 P0C1H4 P0C1H5 P0CG62 P62801 P63283 P79781 Q5ZML0 Q8QGH2 Q9PSW9	BABAM2 BRE EYA1 EYA2 EYA4 H2AFX H2B-I H2B-II H2B-III H2B-IV H2B-V H2B-VI H2B-VII H2B-VIII H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII HIST1H2B5L KDM4A KDM4B LOC100859381 LOC426037 MAPK8 PIAS4 RPS27A SUMO1 UBA80 UBB UBC9 UBCE9 UBE2I	Gallus gallus (chicken)

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