GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	November 12, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **270** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
FGFR2b ligand binding and activation	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 3 Fibroblast growth factor receptor 2 Fibroblast growth factor	A0A3Q2TTH8 P18461 P19596 P48801 Q5KRA4	CEK3 FGF-3 FGF1 FGF10 FGF3 FGF7 FGFR2 Fgf7	Gallus gallus (chicken)
Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)	Dipeptidyl peptidase 4 G protein subunit alpha transducin 3 G protein subunit beta 3 G protein subunit gamma 13 G protein-coupled receptor 119 Gastrin-releasing peptide Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Pro-glucagon	A0A1D5P7Z5 A0A1D5PJA5 E1C1U6 F1NLV4 F1P3R0 M9NJI3 P01295 P68259	DPP4 GCG GNAT3 GNB1 GNB3 GNG13 GPR119 GRP	Gallus gallus (chicken)	G58161NS
Signaling by Activin	Activin receptor type-2A Inhibin beta B chain Mothers against decapentaplegic homolog 3 Mothers against decapentaplegic homolog Mothers against decapentaplegic homolog Transforming growth factor beta receptor 3 receptor protein serine/threonine kinase	A0A1D5NUH3 A0A3Q2TUT8 P84023 Q8UWF3 Q90669 Q90998 R4GIS0	ACVR1C ACVR2A INHBB LOC769000 MADH2 MADH3 SMAD3 TGFBR3	Gallus gallus (chicken)
Common Pathway of Fibrin Clot Formation	Coagulation factor X Coagulation factor XIII A chain Endothelial protein C receptor Serpin family D member 1 Serpin family E member 2	A0A1D5PLZ2 E1BWG1 E1BWU2 P25155 Q4ADW2	F10 F13A1 FX PROCR SERPIND1 SERPINE2	Gallus gallus (chicken)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus	Coagulation factor X Osteocalcin	A0A1D5PRL0 P25155	BGLAP F10 FX	Gallus gallus (chicken)
MAP2K and MAPK activation	14-3-3 protein beta/alpha Dual specificity mitogen-activated protein kinase kinase 1 Fibronectin GTPase HRas GTPase NRas IQ motif containing GTPase activating protein 1 Integrin beta Kinase suppressor of ras 2 Proto-oncogene tyrosine-protein kinase Src RAF proto-oncogene serine/threonine-protein kinase Ras-related protein Rap-1b Serine/threonine-protein kinase B-raf Vinculin small monomeric GTPase small monomeric GTPase	A0A1D5PIZ8 A0A1D5PT95 A0A1D5PX90 F1NSA8 P00523 P05625 P08642 P11722 P12003 Q04982 Q5F352 Q5ZHX1 Q5ZIF0 Q5ZLQ6 Q92071	BRAF FN1 HRAS HRAS1 IQGAP3 ITGB3 KRAS KSR2 MIL NRAS RAF1 RAP1A RAP1B RCJMB04_27f19 RMIL SRC VCL VINC1 YWHAB	Gallus gallus (chicken)
Scavenging by Class A Receptors	Apolipoprotein A-I Collectin-11 Endoplasmin	A0A1D5PPN9 A0A3Q3A736 P08250	APOA1 COLEC11 HSP90B1	Gallus gallus (chicken)	G70323CJ G82576YO
Assembly of the ORC complex at the origin of replication	Histone H2A-IV Histone H2A.J Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2/3/4/6 Histone H2B 5 Histone H2B 7 Histone H2B 8 Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Importin subunit alpha Karyopherin subunit beta 1	A0A1D5P1W7 A0A1D5PY49 A0A1L1RNY8 A0A3Q2UDI2 F1NDD7 F1P5G5 F7B5S0 P02263 P02272 P0C1H3 P0C1H4 P0C1H5 P62801 P70082 P84229 P84247 Q9PSW9	H2A-IX H2AF H2AFX H2AZ2 H2B-I H2B-II H2B-III H2B-IV H2B-V H2B-VI H2B-VII H2B-VIII H3-I H3-II H3-III H3-IV H3-IX H3-V H3-VI H3-VII H3-VIII H3-X H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII HIST1H2B5L KPNA6 KPNB1 LOC100859381 LOC426037	Gallus gallus (chicken)
NF-kB is activated and signals survival	Nuclear factor NF-kappa-B p105 subunit Polyubiquitin-B Sequestosome 1 TNF receptor-associated factor Tumor necrosis factor receptor superfamily member 16 Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P546 A0A1D5PLN4 E1C626 P0CG62 P18519 P79781 Q04861	NFKB1 NGFR RPS27A SQSTM1 TNFRSF16 TRAF6 UBA80 UBB	Gallus gallus (chicken)
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amphiregulin BDNF/NT-3 growth factors receptor Betacellulin Brain-derived neurotrophic factor Epigen Epiregulin Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor receptor 1 Fibroblast growth factor receptor 2 Fibroblast growth factor receptor 3 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor-bound protein 2 Kit ligand Mast/stem cell growth factor receptor Kit NT-3 growth factor receptor Neuregulin 2 Neurotrophin-3 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol-4-phosphate 5-kinase type 1 beta Phosphatidylinositol-4-phosphate 5-kinase, type I, gamma Phosphatidylinositol-5-phosphate 4-kinase type 2 beta Phosphoinositide 3-kinase adapter protein 1 Phosphoinositide-3-kinase regulatory subunit 2 Platelet-derived growth factor subunit A Proheparin-binding EGF-like growth factor Proto-oncogene tyrosine-protein kinase Src Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase T cell receptor associated transmembrane adaptor 1 Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type 11 Uncharacterized protein phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A1D5PKH0 A0A1D5PV96 A0A1D5PVP0 A0A3Q2TTH8 A0A3Q2U639 A0A3Q2U804 A0A3Q3ACS4 A3R0S3 E1BZW7 E1C021 E1C2C5 F1NCL8 F1ND21 F1NHX1 F1NJR9 F1NRE1 F1P1P4 F1P5Y5 P00523 P18460 P18461 P19596 P21804 P25429 P48800 P48801 Q08156 Q09108 Q197G3 Q4R0X9 Q5EG71 Q5F337 Q5F4A2 Q5KRA4 Q645M5 Q64EU6 Q6LC82 Q90687 Q90WK2 Q91044 Q91987 Q9DDT2 Q9I950 Q9W7C5 R4GIR0 R4GMA6 R4GMB5	AREG BCAP BDNF BTC CEK1 CEK2 CEK3 EGFR EPGN EREG FGF-18 FGF-3 FGF1 FGF10 FGF18 FGF19 FGF2 FGF23 FGF3 FGF4 FGF6 FGF7 FGF8 FGFR1 FGFR2 FGFR3 FGFR4 FRS2 FYN Fgf16 Fgf7 GRB2 HBEGF HEGFL KIT KITLG NRG2 NTF3 NTRK2 NTRK3 PDGF-A (L) PDGFA PIK3AP1 PIK3CB PIK3CD PIK3R1 PIK3R2 PIP4K2B PIP5K1B PIP5K1C PTPN11 RCJMB04_38b23 RHOG SCF SRC TRAT1 TRKB TRKC cRac1A	Gallus gallus (chicken)
NFG and proNGF binds to p75NTR	Tumor necrosis factor receptor superfamily member 16	P18519	NGFR TNFRSF16	Gallus gallus (chicken)
Sialic acid metabolism	Alpha-2,8-sialyltransferase Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase Beta-galactoside alpha-2,6-sialyltransferase 2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase Major facilitator superfamily (MFS) profile domain-containing protein N-acetylneuraminate synthase ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 exo-alpha-sialidase	A0A1D5PEI3 A0A1D5PIR8 A0A3Q2TVY6 E1BZW3 F6VMN5 P79783 Q11200 Q5ZL94 Q5ZMH8 Q6ZXD0 Q92183 R4GHQ6	NANS NEU2 RCJMB04_7b17 SIAT4A SIAT7A SIAT8C ST3GAL1 ST6GAL2 ST6GALNAC1 ST6GALNAC5 ST8SIA4 ST8SIA5 ST8SIA6 Sial-T2	Gallus gallus (chicken)
Biosynthesis of EPA-derived SPMs	Prostaglandin G/H synthase 2	P27607	CEF-147 PTGS2	Gallus gallus (chicken)
FGFR1c ligand binding and activation	Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Transforming growth factor beta receptor 3	E1BZW7 F1P5Y5 P19596 P21804 P48800 Q4R0X9 Q90998 R4GIR0	CEK1 FGF1 FGF2 FGF23 FGF4 FGF6 FGF8 FGFR1 TGFBR3	Gallus gallus (chicken)
ADP signalling through P2Y purinoceptor 1	Cytosolic phospholipase A2 G protein subunit beta 3 G protein subunit beta 4 G protein subunit gamma 13 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma P2Y purinoceptor 1 Proto-oncogene tyrosine-protein kinase Src mitogen-activated protein kinase	A0A1D5P7Z5 A0A1D5PIQ5 A0A1D5PLZ8 E1BW98 E1C1U6 E1C795 F1NLV4 P00523 P34996 P49147 Q5F3B5 Q5ZJ03 Q71RI7 R4GFT9 R4GKD1	CPLA2 GNA11 GNAQ GNB1 GNB3 GNB4 GNG10 GNG12 GNG13 GNG2 GNG5 GNGT2 MAPK14 P2RY1 PLA2G4 PLA2G4A SRC	Gallus gallus (chicken)
Platelet Adhesion to exposed collagen	Glycoprotein IX platelet Glycoprotein Ib platelet subunit beta Tsukushi	A0A3Q3AXX7 F1P1G3 Q65Z91	GP1BB GP9 LRRC54 TSK TSKU	Gallus gallus (chicken)
Syndecan interactions	Fibroblast growth factor 2 Integrin beta Protein kinase C Syndecan-4 Syndecan Syndecan Transforming growth factor beta	F1NV24 H9CX01 P48800 P49416 Q8JIY0 Q92071 R4GHL2	FGF2 ITGB3 PRKCA SDC1 SDC2 SDC4 TGFB1	Gallus gallus (chicken)
Proton-coupled monocarboxylate transport	Monocarboxylate transporter 1 Monocarboxylate transporter 2	F1NVU4 Q5ZLZ6	RCJMB04_4e8 SLC16A7	Gallus gallus (chicken)
EGFR downregulation	Amphiregulin Betacellulin Cell division control protein 42 homolog Endophilin-A1 Epigen Epiregulin Growth factor receptor-bound protein 2 Polyubiquitin-B Proheparin-binding EGF-like growth factor Protein sprouty homolog 1 Receptor protein-tyrosine kinase Rho guanine nucleotide exchange factor 7 SH3 domain containing GRB2 like 3, endophilin A3 SH3 domain-containing protein Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P546 A0A1D5PKH0 A0A3Q2TZR1 A3R0S3 A4LA71 F1NB17 F1NJR9 P0CG62 P79781 Q5EG71 Q5ZMQ7 Q645M5 Q64EU6 Q8AXV1 Q90694 Q9W7C5	AREG ARHGEF7 BTC CDC42 EGFR EPGN EREG GRB2 HBEGF HEGFL RCJMB04_1g20 RPS27A SH3GL2 SH3GL3 SH3P4 SPRY1 UBA80 UBB	Gallus gallus (chicken)
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Core-binding factor beta subunit Histone H2A-IV Histone H2A.J Histone H2A.V Histone H2A Histone H2A Histone H2A Histone H2B 1/2/3/4/6 Histone H2B 5 Histone H2B 7 Histone H2B 8 Histone H2B Histone H2B Histone H3.2 Histone H3.3 Histone H4 Histone deacetylase 1 RB binding protein 5, histone lysine methyltransferase complex subunit Runt-related transcription factor SIN3 transcription regulator family member A SIN3 transcription regulator family member B Uncharacterized protein	A0A1D5PY49 A0A1L1RNY8 A0A3Q2TTQ9 A0A3Q2UDI2 E1BX21 F1NDD7 F1NMJ8 F1NQP4 F1P5G5 P02263 P02272 P0C1H3 P0C1H4 P0C1H5 P56517 P62801 P70082 P84229 P84247 Q5ZIL1 Q5ZLX3 Q9PSW9	CBFB H2A-IX H2AF H2AFX H2AZ2 H2B-I H2B-II H2B-III H2B-IV H2B-V H2B-VI H2B-VII H2B-VIII H3-I H3-II H3-III H3-IV H3-IX H3-V H3-VI H3-VII H3-VIII H3-X H4-I H4-II H4-III H4-IV H4-V H4-VI H4-VII HDAC1 HDAC1A HIST1H2B5L LOC100859381 LOC426037 RBBP5 RCJMB04_25e24 RUNX1 SIN3A SIN3B	Gallus gallus (chicken)
GRB2 events in EGFR signaling	Amphiregulin Betacellulin Epigen Epiregulin GTPase HRas GTPase NRas Growth factor receptor-bound protein 2 Proheparin-binding EGF-like growth factor Receptor protein-tyrosine kinase SOS Ras/Rac guanine nucleotide exchange factor 1 small monomeric GTPase	A0A1D5PEZ2 A0A1D5PKH0 A0A1D5PT95 A3R0S3 F1NJR9 P08642 Q5EG71 Q5F352 Q645M5 Q64EU6 Q9W7C5	AREG BTC EGFR EPGN EREG GRB2 HBEGF HEGFL HRAS HRAS1 KRAS NRAS SOS1	Gallus gallus (chicken)
Collagen biosynthesis and modifying enzymes	ADAM metallopeptidase with thrombospondin type 1 motif 3 Collagen alpha-1(XVII) chain Collagen alpha-2(VI) chain Collagen type I alpha 1 chain Collagen type I alpha 2 chain Collagen type III alpha 1 chain Collagen type IV alpha 1 chain Collagen type XII alpha 1 chain Prolyl 3-hydroxylase 2 Serpin H1	A0A1D5P8P3 A0A1D5PE57 A0A1D5PYU1 A0A1L1RPW4 A0A5H1ZRJ7 F1NVD1 P13731 P15988 Q6JHU7 Q90584	ADAMTS3 BP180 BPAG2 COL12A1 COL17A1 COL1A1 COL1A2 COL3A1 COL4A1 COL6A2 HSP47 LEPREL1 P3H2 SERPINH1	Gallus gallus (chicken)
Downstream signaling of activated FGFR1	Fibroblast growth factor 10 Fibroblast growth factor 1 Fibroblast growth factor 2 Fibroblast growth factor 3 Fibroblast growth factor receptor 1 Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibronectin leucine rich transmembrane protein 2 Leucine-rich repeat transmembrane protein FLRT3	A0A3Q2TTH8 E1BZW7 E1C6W5 F1NUK7 F1P5Y5 P19596 P21804 P48800 P48801 Q4R0X9 R4GIR0	CEK1 FGF-3 FGF1 FGF10 FGF2 FGF23 FGF3 FGF4 FGF6 FGF8 FGFR1 FLRT2 FLRT3	Gallus gallus (chicken)
Regulation of FZD by ubiquitination	Frizzled-4 Leucine rich repeat containing G protein-coupled receptor 4 Leucine rich repeat containing G protein-coupled receptor 5 Polyubiquitin-B Protein Wnt-3a R-spondin 1 R-spondin 2 Ubiquitin B Ubiquitin-ribosomal protein eS31 fusion protein	A0A1D5P546 A0A1D5PB24 E1BVU3 E1C2F8 I0IVW2 P0CG62 P79781 Q2LMP1 Q9IA05	FZ4 FZD4 LGR4 LGR5 RPS27A RSPO1 RSPO2 UBA80 UBB WNT3A	Gallus gallus (chicken)
ESR-mediated signaling	peptidylprolyl isomerase peptidylprolyl isomerase	A0A3Q2U9P1 Q646T7	FKBP4 FKBP5 FKBP51	Gallus gallus (chicken)

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