GlyCosmos Portal

GlyCosmos Pathways

Integrated of pathway data, containing glycoproteins and glycans obtained from Reactome and the Metabolism of carbohydrates in Escherichia coli O-antigens obtained from ECODAB. Search by pathway name, species, and protein name.

Source	Last Updated
Reactome	March 20, 2024
ECODAB	April 1, 2019

Displaying entries **1 - 25** of **145** in total

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Pathway Name	Protein Name	UniProt ID	Gene Symbol	Organism	GlyTouCan ID
Hedgehog 'on' state	Cell division cycle 73 Cullin-3 E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase E3 ubiquitin-protein ligase Ellis van Creveld syndrome 2 Ellis-van Creveld syndrome protein G-protein coupled receptor 161 GLI family zinc finger 1 GLI family zinc finger 2 GLI family zinc finger 3 Novel protein Numb homolog (Drosophila) Patched 1 Protein smoothened Speckle-type POZ protein-like Speckle-type POZ protein Suppressor of fused homolog Ubiquitin-ribosomal protein eL40 fusion protein Ubiquitin-ribosomal protein eS31 fusion protein	A0A6I8PYJ0 A0A6I8QGB6 A0A6I8RCT3 A0A6I8RRT2 A0A6I8S8I3 A0A6I8SVL3 A0A803JPT9 A0A803JRJ1 A0JM32 A4IH32 A4IHP4 B3DLW7 B3DM66 F6V904 F7DZP4 Q07FY6 Q28FM7 Q5BKG2 Q6AZL4 Q6GL58 Q6P8B3	LOC100216108 LOC548926 MGC89679 RPS27A Xsufu aif4 aip4 cdc73 cep52 cul3 dwf-1 evc evc2 evcl gli1 gli2 gli3 gpr161 hmg20 hrpt2 hubcep52 itch itchy napp1 numb pro1280 ptch1 rbx1 rpl40 rps27a s171 smo smurf1 smurf2 spop spopl sufu sufuh sufuxl uba52 ubc ubi-p63e	Xenopus tropicalis (tropical clawed frog)
Transport of inorganic cations/anions and amino acids/oligopeptides	Amino acid transporter Amino acid transporter Amino acid transporter Amino acid transporter Mitochondrial S-adenosylmethionine carrier protein	A0A6I8QSR9 A0A6I8RPW4 A0A803K844 F7CSQ4 Q6GLA2	ea6 eaat1 glast glast-1 glast1 samc slc1a1 slc1a3 slc1a6 slc1a7 slc25a26	Xenopus tropicalis (tropical clawed frog)
Crosslinking of collagen fibrils	Peroxidasin protein-lysine 6-oxidase protein-lysine 6-oxidase	A0A7D9NKV7 A4IGL7 A4IHQ3	LOC100124878 lol loxl loxl-1 loxl1 loxl4 pxdn pxn	Xenopus tropicalis (tropical clawed frog)
Fructose biosynthesis	Aldo-keto reductase family 1 member B1 Sorbitol dehydrogenase	Q5M8L5 Q5XGB0	akr1b1 akr1b7 sord	Xenopus tropicalis (tropical clawed frog)	G58161NS
G alpha (q) signalling events	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled 5-hydroxytryptamine receptor 2A 5-hydroxytryptamine receptor 2B Alpha-1A adrenergic receptor Alpha-1B adrenergic receptor Amyloid-beta A4 protein Angiotensinogen Annexin Arginine vasopressin receptor 1A Arginine vasopressin receptor 1B Bombesin receptor subtype-3 Chemokine (C-C motif) receptor 2 Chemokine-like receptor 1 Cholecystokinin Endothelin receptor type B Endothelin-1 receptor Endothelin-1 Endothelin-2 Endothelin-3 Extracellular calcium-sensing receptor F2R like trypsin receptor 1 F2R-like thrombin or trypsin receptor 3 Free fatty acid receptor 2 G protein-coupled receptor 132 G protein-coupled receptor 143 G protein-coupled receptor 23 G protein-coupled receptor 68 G protein-coupled receptor kinase G-protein coupled receptor 39 G-protein coupled receptor family C group 6 member A Gastrin-releasing peptide receptor Glucagon receptor Glucagon Glutamate receptor, metabotropic 1 Glutamate receptor, metabotropic 5 Gonadotropin releasing hormone receptor isoform X1 Growth hormone secretagogue receptor type 1 Guanine nucleotide binding protein (G protein), beta polypeptide 4 Guanine nucleotide binding protein, beta 3 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit alpha Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit beta-5 Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Guanine nucleotide-binding protein subunit gamma Histamine H1 receptor Hypocretin neuropeptide precursor Kininogen-1 LOC100124893 protein LOC100145150 protein LOC100145570 protein LPA2 protein Leukotriene B4 receptor 2 Lysophosphatidic acid receptor 3 Lysophosphatidic acid receptor 6 Melanin-concentrating hormone receptor 1 Melanopsin isoform X1 Mesotocin-neurophysin MT Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor Muscarinic acetylcholine receptor Neuromedin U Neuromedin-K receptor Neuromedin-U receptor 1 Neuromedin-U receptor 2 Neuropeptide FF receptor 1 Neuropeptide FF receptor 2 Neuropeptide S receptor 1 Neurotensin receptor 2 Neurotensin/neuromedin N Novel 7 transmembrane receptor (Rhodopsin family) proteinNovel 7 transmembrane receptor (Rhodopsin family) protein Orexigenic neuropeptide QRFP Ovarian cancer G-protein coupled receptor 1 Oxytocin receptor P2Y purinoceptor 10 P2Y purinoceptor 11 P2Y purinoceptor 1 P2Y purinoceptor 2 Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Platelet-activating factor receptor Pro-MCH Pro-thyrotropin-releasing hormone Prostaglandin F2-alpha receptor Proteinase-activated receptor 1 Prothrombin Pyroglutamylated RF-amide peptide receptor isoform X1 Regulator of G-protein signaling 13 Regulator of G-protein signaling 17 Regulator of G-protein signaling 18 Regulator of G-protein signaling 1 Regulator of G-protein signaling 2 Regulator of G-protein signaling 4 Regulator of G-protein signaling 5 Regulator of G-protein signaling 8 Regulator of G-protein signaling 8 Rho guanine nucleotide exchange factor 25 Substance-P receptor Tachykinin 3 Thromboxane A2 receptor Thromboxane A2 receptor Tyrosine-protein kinase Urotensin-2 receptor phosphatidylinositol-4,5-bisphosphate 3-kinase	A0A1B8Y6Y7 A0A1B8Y8P3 A0A6I8PJ30 A0A6I8PNV7 A0A6I8PRA9 A0A6I8PRL9 A0A6I8PX40 A0A6I8PZ96 A0A6I8Q016 A0A6I8Q0P6 A0A6I8Q186 A0A6I8Q3X7 A0A6I8Q821 A0A6I8QBR7 A0A6I8QYT3 A0A6I8R0J6 A0A6I8R459 A0A6I8RCH1 A0A6I8RDQ6 A0A6I8RMZ6 A0A6I8RPP0 A0A6I8RVJ2 A0A6I8S283 A0A6I8S4R6 A0A6I8SDL6 A0A6I8SIM1 A0A6I8SLE9 A0A6I8SRX2 A0A6I8SUK7 A0A6I8T2N1 A0A6I8T2S3 A0A7D9N0J0 A0A7D9NKE5 A0A7D9NMF6 A0A803J404 A0A803J421 A0A803J4X7 A0A803J912 A0A803JAK1 A0A803JAL7 A0A803JBF7 A0A803JDI8 A0A803JKX4 A0A803JTA2 A0A803K8E3 A0A803KBF8 A0A803KD59 A0A803KEZ7 A0JM97 A4IGZ2 A4IHT5 A4IIB5 A4QNP4 A8KBE2 A8WGF0 B0BLW6 B0JZ48 B1H1F0 B1H380 B2GUH7 B3DLB1 F6PHM9 F6PV41 F6RQM0 F6SU43 F6TB92 F6VSL4 F6WBX6 F6WHY7 F6WJ54 F6WKZ2 F6X0Y1 F6XN13 F6Z0J4 F6ZEU0 F7AA76 F7ADY2 F7ANL6 F7AZJ9 F7AZS9 F7B836 F7BN11 F7C7K9 F7CAM3 F7CRB6 F7D9G8 F7E412 F7EBE7 F7EEJ5 F7EHY9 F7ELH9 F7ET98 I4IYA2 K9J7P8 Q05B33 Q0P4I5 Q0V9S6 Q0VA29 Q0VFF5 Q0VFL5 Q28BQ5 Q28G20 Q28H40 Q28IS1 Q5BKF9 Q5FVW1 Q5M8L6 Q5XGD8 Q66IM3 Q66JF0 Q66JK3 Q68PF6 Q6DF33 Q6DJB6 Q6GLI0 Q6P2X5	EDG4 Ednra G(q) GNRHR1 GNRHR3/II LOC100038286 LOC100124773 LOC100124893 LOC100124978 LOC100127646 LOC100127678 LOC100144924 LOC100145150 LOC100145351 LOC100145370 LOC100145570 LOC100170477 LOC100487890 LOC100491504 LOC101732366 LOC101733637 LOC116406441 LOC733883 LPA2 MGC145965 MGC147439 MGC76270 MGC79629 PI3-kinase PI3K-alpha UTR1 XB991396 XGB1 XGbeta1 XIFP XRgs4 XRgs4a aaa abcds abeta abpp ad1 adra1a adra1b agmx1 agt anx1 anxa1 anxa1.1 app appi arhgef25 atk avpr1a avpr1b bpk brs3 btk casr cck ccr2 chrm1 chrm3 chrm5 ctfgamma cvap edg-2 edg2 edn1 edn2 edn3 ednra ednra-a ednra-b ednrb ednrb1-a endo-r eta etar etax etb etra etrb f2 f2r f2rl1 f2rl2 f2rl3 ffar2 g-alpha-q g0s8 gaip gaq gcg gcgr geft ghsr glp1 glp2 gna14 gna14-a gna14-b gna15 gnaq gnaq-a gnaq-b gnb1 gnb2 gnb3 gnb4 gnb5 gng10 gng12 gng2 gng3 gng4 gng7 gng7-a gng7-b gngt1 gngt2.1 gnrhr gnrhr3/ii gpr103 gpr132 gpr143 gpr23 gpr24 gpr26 gpr68 gprc6a.2 grk3 grm1 grm5 grpp grpr hcrt hrh1 hscr hscr2 htr2a htr2b htr2c imd1 kng1 lpa1 lpa1r lpa1r1 lpa2 lpa4 lpar1 lpar1-a lpar1-b lpar2 lpar3 lpar4 lpar6 lpc1 ltb4r2 mch1r mchr1 mchr1.2 mchr1a nmu nmur1 nmur2 npffr1 npffr1.1 npffr2 npsr1 nts ntsr2 nys6 oa1 opn4 oxt oxtr p2ry1 p2ry10 p2ry11 p2y1 p2y11 p55 p55-gamma p63rhogef pafr par3 pi-plc pi3-k pi3k pik3ca pik3r1 pik3r2 pik3r3 plc-154 plc-i plc154 plcb1 plcb2 plcb3 pmch pn2 psctk1 ptafr ptger1 ptgfr qrfp qrfpr rgp4 rgs1 rgs13 rgs16 rgs17 rgs18 rgs19 rgs2 rgs4 rgs5 rgs8 rgsgaip sczd9 slc1 tac3 tacr1 tacr3 tbxa2r trh trh-a trh-b uts2b uts2d uts2r vzg-1 vzg1 xcr1 xgnrhr xla xrgs5	Xenopus tropicalis (tropical clawed frog)
O-linked glycosylation	Beta-1,4-glucuronyltransferase 1 Dolichyl-phosphate-mannose--protein mannosyltransferase Dolichyl-phosphate-mannose--protein mannosyltransferase Dystroglycan 1 LARGE xylosyl- and glucuronyltransferase 1 LARGE xylosyl- and glucuronyltransferase 2 Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2 Protein O-mannose kinase UDP-GalNAc	A0A6I8QLH7 A0A6I8REH9 A0A803J9E3 B7ZTF0 F6YEH0 F7D9W4 F7E5Y2 K9J7L1 Q5M900 Q5NDE6	156dag LOC100158594 a3a ago61 agrnr b3galnt2 b4gat1 dag dag1 dg gtdc2 gyltl1b large1 large2 pomgnt1 pomgnt2 pomk pomt1 pomt2	Xenopus tropicalis (tropical clawed frog)
Glycerophospholipid biosynthesis	Acylglycerol kinase, mitochondrial Copine I Copine III Copine VII	A0A6I8QKY6 A0A6I8QQ62 A0A6I8T160 A0A803KED9	agk cpne1 cpne3 cpne7 mulk	Xenopus tropicalis (tropical clawed frog)
Acyl chain remodelling of PC	Cytosolic phospholipase A2 Group XIIA secretory phospholipase A2 precursor Lysophosphatidylcholine acyltransferase 1 Lysophospholipid acyltransferase 2 Lysophospholipid acyltransferase LPCAT4 Phospholipase A and acyltransferase 3 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Phospholipase A2 Secretory phospholipase A2 receptor lysoplasmalogenase lysoplasmalogenase phospholipase A2 phospholipase A2	A0A6I8PMU8 A0A803K0T6 A0A803K1C6 A0A803KFH5 A4IIH1 A9UMH3 B0BMQ4 B1H311 B1WAZ6 F6PVH0 F6S3K0 F6TFZ5 F6VH26 F7AE83 Q28C60 Q28GM9	LOC100135356 LOC100145092 LOC100145529 LOC116407767 agpat7 aytl3 cpla2 lpcat1 lpcat4 mboat1 mboat2 oact2 pla2 pla2a pla2g12a pla2g1b pla2g1bl pla2g2d pla2g3 pla2g4 pla2g4a pla2g4f pla2g6 pla2r1 plaat4 ppla2 tmem86a tmem86b	Xenopus tropicalis (tropical clawed frog)
FGFR1c and Klotho ligand binding and activation	Fibroblast growth factor 23 Fibroblast growth factor 23 Fibroblast growth factor receptor Klotho	A0A6I8PM12 A0A6I8SJT2 A0A803K518 Q28J96	X1FGFR XFGFR-1 bfgfr cd331 cek fgf23.1 fgf23.2 fgfbr fgfr-1 fgfr1 fgfr1-a fgfr1-b flg flt-2 flt2 hbgfr kal2 kl n-sam ogd xfgfr1	Xenopus tropicalis (tropical clawed frog)
Atorvastatin ADME	ABC-type glutathione-S-conjugate transporter Cytochrome P450 3A9 Cytochrome P450 3A Paraoxonase Solute carrier organic anion transporter family member Solute carrier organic anion transporter family member	A0A6I8Q487 A0A6I8S1Y8 A0A803JJU8 F7B8B6 Q5EBE6 Q6DF09	MGC108372 OATP2B1 abcc2 cyp3a4 cyp3a4.1 cyp3a4.2 cyp3a4.3 esa lst-3tm13 lst3 mvcd5 oatp1b3 oatp8 pon pon1 pon2 slc21a8 slco1b3 slco2b1	Xenopus tropicalis (tropical clawed frog)
Synthesis of 5-eicosatetraenoic acids	Arachidonate 5-lipoxygenase-activating protein Arachidonate 5-lipoxygenase Leukotriene C4 synthase Leukotriene C4 synthase Paraoxonase	A0A803J7H0 F6QV45 F7DHS8 Q4VA83 Q6DF09	LOC100127769 alox5 alox5ap esa flap ltc4s ltc4s.1 ltc4s.2 mgst2 mvcd5 pon pon1 pon2	Xenopus tropicalis (tropical clawed frog)
Keratan sulfate degradation	Beta-galactosidase-1-like protein precursor Beta-galactosidase Beta-galactosidase Beta-hexosaminidase Fibromodulin Lumican N-acetylglucosamine-6-sulfatase Osteomodulin Prelp protein	A0A6I8PLI9 A0A6I8SFJ2 A4IIL0 A9JRM2 B1H351 F6RIJ3 Q28E48 Q5XHB8 Q640B1	LOC100135105 LOC100145556 enc-1as fmod glb1 glb1l glb1l2 gns hexb ldc lum omd prelp slrr2d	Xenopus tropicalis (tropical clawed frog)	G09546QO G20239CJ G27025MB G50451AA G80016QC G82768YB G85384LV
Arachidonic acid metabolism	Acyltransferase Cytosolic phospholipase A2 Fatty acid amide hydrolase, gene 2 Fatty-acid amide hydrolase 2	A0A7D9NKM3 B1WAZ6 F6PSQ8 F6TLW5	LOC496823 cpla2 dgat2l6 faah faah-1 faah.2 faah2 pla2g4 pla2g4a	Xenopus tropicalis (tropical clawed frog)
Hedgehog 'off' state	G-protein coupled receptor 161 GLI family zinc finger 1 GLI family zinc finger 2 GLI family zinc finger 3 Intraflagellar transport 140 Intraflagellar transport 172 Intraflagellar transport 88 Intraflagellar transport protein 122 homolog Intraflagellar transport protein 52 homolog isoform X1 Intraflagellar transport protein 57 homolog Meckel syndrome type 1 protein isoform X1 Patched 1 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Protein fantom Protein fuzzy homolog Protein inturned Protein kinase, cAMP dependent regulatory, type I beta Protein smoothened Suppressor of fused homolog Tetratricopeptide repeat domain 21B Tubby-related protein 3 WD repeat domain 19 adenylate cyclase adenylate cyclase adenylate cyclase adenylate cyclase adenylate cyclase adenylate cyclase adenylate cyclase cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase type I-alpha regulatory subunit cAMP-dependent protein kinase type II-alpha regulatory subunit	A0A6I8PRC7 A0A6I8PXX7 A0A6I8PZU0 A0A6I8Q2A9 A0A6I8Q3A2 A0A6I8QBQ5 A0A6I8QGB6 A0A6I8QGP8 A0A6I8QPV8 A0A6I8RCT3 A0A6I8RRT2 A0A6I8SFS5 A0A6I8SXB5 A0A803JHS7 A0A803JRJ1 A0A803K6A2 A2VCZ2 A8WGF4 A8WH07 B1H1K3 B3DLW7 B3DM66 F6U5F9 F6ZYD6 F7DZP4 F7EI83 Q0IHN4 Q0P4Y3 Q28HX4 Q28I36 Q2HZX7 Q5BL84	Adcy3 LOC100127741 Xsufu ac7 adcy1 adcy4 adcy5 adcy6 adcy7 adcy8 c305c8.4 c380f5.1 cgi-53 cnc1 dnajc27 dnajc27-a dnajc27-b fuz fuzzy fy gli1 gli2 gli3 gpr161 gs114 ift122 ift140 ift172 ift52 ift57 ift88 intu mes mks mks1 ngd5 pik3cg pkr1 ppnad1 prkaca prkar1 prkar1a prkar1a.2 prkar1b prkar2a prkar2b pro1280 ptch1 pwdmp rap1 rpgrip1l smo sufu sufuh sufuxl tse1 ttc21b tubl3 tulp3 wdr19 wdtc2	Xenopus tropicalis (tropical clawed frog)
Neurotransmitter release cycle	N-acylethanolamine-hydrolyzing acid amidase	Q6DJ82	asahl naaa	Xenopus tropicalis (tropical clawed frog)
Calcitonin-like ligand receptors	Calcitonin gene-related peptide 2 isoform X1 Calcitonin gene-related peptide type 1 receptor Calcitonin receptor Islet amyloid polypeptide Receptor activity-modifying protein 1	A0A6I8PR90 A0A803JC56 A0A803K560 Q0IIU7 Q0P4Y4	MGC147096 calca calcr calcrl iapp ramp1	Xenopus tropicalis (tropical clawed frog)
RAF/MAP kinase cascade	Amphiregulin Angiopoietin-1 Astrocytic phosphoprotein PEA-15 Beta-klotho Betacellulin Fibroblast growth factor 23 Fibroblast growth factor 23 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor substrate 3 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Insulin receptor substrate 1 Insulin receptor substrate 2 Kit ligand Klotho LOC100127663 protein Mast/stem cell growth factor receptor Mitogen-activated protein kinase Multifunctional fusion protein OMA1 zinc metallopeptidase Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Platelet-derived growth factor receptor alpha Platelet-derived growth factor subunit B Proheparin-binding EGF-like growth factor RAS guanyl-releasing protein 1 RAS guanyl-releasing protein 3 RAS guanyl-releasing protein 4 Ran-binding protein 9 Ras protein-specific guanine nucleotide-releasing factor 2 Ras-GEF domain-containing family member 1A Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Receptor-type tyrosine-protein phosphatase alpha SHC (Src homology 2 domain-containing)-transforming protein 2 SOS Ras/Rac guanine nucleotide exchange factor 1 Spectrin alpha chain, non-erythrocytic 1 isoform X1 Spectrin beta chain Spectrin beta chain Tyrosine-protein kinase phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A6I8PM12 A0A6I8PW37 A0A6I8PXN2 A0A6I8Q186 A0A6I8Q702 A0A6I8QCY1 A0A6I8QGX4 A0A6I8QQS1 A0A6I8QXV8 A0A6I8R0X7 A0A6I8R680 A0A6I8R8T1 A0A6I8RAX6 A0A6I8RSV6 A0A6I8SCF3 A0A6I8SJT2 A0A6I8SLH0 A0A6I8SUV8 A0A6I8SVI1 A0A6I8T2P4 A0A803J293 A0A803JX40 A0A803K518 A0A803KIA6 A0JM95 A4IHL2 A8KBG4 A9UMH6 B0BLW6 B1H1E3 B1H1K2 B4F6K4 B4F6V0 B5DE89 B7U3X7 B7U3X8 B7U4G3 B7UC02 B7ZSQ9 F6UFM4 F6VBJ9 F6X0U7 F6XSB5 F6Z0J4 F6ZB49 F7AI95 F7AN80 F7BJ20 F7CD16 F7E4V9 L7MUI0 Q0IHS8 Q28DZ3 Q28FM1 Q28GC1 Q28H11 Q28J96 Q66IF7 Q66II3	FGF-8 HBGF-1 HBGF-2 HBGF-4 INT-2 LOC100124862 LOC100127663 LOC100144924 LOC100145251 LOC100145359 LOC100158513 LOC100498409 PI3-kinase PI3K-alpha X1FGFR XEFGF XFGFR-1 XFGFR-4 XFGFR-4a XPTPa XSNT Xfgf-4 Xfgf-8 Xfgf4 Xfgf8 Xkl-1 Xsl Xsl-1 Xsl-2 aFGF aigf angpt1 areg bfgf bfgfr btc c-kit c-sis cd331 cd334 cek ecgf ecgf-beta ecgfa ecgfb efgf egf egfr erbb4 erk erk2 ert1 fgf-1 fgf-10 fgf-19 fgf-2 fgf-3 fgf-4 fgf-6 fgf-8b fgf-alpha fgf1 fgf10 fgf16 fgf19 fgf2 fgf22 fgf23.1 fgf23.2 fgf3 fgf4 fgf4-a fgf4-b fgf5 fgf6 fgf8 fgf8a fgf8b fgf9 fgfa fgfb fgfbr fgfe fgfr-1 fgfr-4 fgfr1 fgfr1-a fgfr1-b fgfr4 fgfr4-a fgfr4-b flg flt-2 flt2 flt3 frs2 frs2a frs2alpha frs2b frs2beta frs3 fyn glio703 grb2 hbegf hbgf-3 hbgf-6 hbgf-8 hbgf1 hbgfr hbgh-2 heptp hgf hlpr hptpa hptpalpha hrasgrp1 hst hst-1 hst2 hstf1 hummat1h int2 irs1 jtk2 k-fgf kal2 kfgf kit kit-a kit-b kitl kitlg kl kl-1 klb krk1 lrp mapk mapk1 mapk1-a mapk1-b mapk2 met mgf mpk1 n-sam n-shc neas nshc ogd oma1 p110-beta p38 p40 p41 p41mapk p42mapk pbt pdgf2 pdgfb pdgfr-alpha pdgfr2 pdgfra pdgfralpha pdgfrb pea-15 pea15 ped-pea15 pi3-k pi3k pi3k92e pi3kbeta pik3c1 pik3ca pik3cb pik3r1 pik3r2 prkm1 prkm2 ptpa ptpra ptprl2 r-ptp-alpha ranbp10 ranbp9 ranbpm rasgef1a rasgrf2 rasgrp rasgrp1 rasgrp3 rasgrp4 rptpa scf scfr shc2 shc3 shcc sis snt snt-1 snt-2 snt1 snt2 sos1 sptan1 sptan1-a sptan1-b sptb sptbn4 steel tek tkf xegf xfgf2 xfgf3 xfgfr1 xfgfr4 xfrs2 xkl-1 xp42 xsrf2	Xenopus tropicalis (tropical clawed frog)
Vitamin C (ascorbate) metabolism	Cytochrome b5 Glucose transporter 14 Glutathione S-transferase omega Glutathione S-transferase omega Glutathione S-transferase omega NADH-cytochrome b5 reductase Solute carrier family 2 member 3 Solute carrier family 23 member 1 Solute carrier family 23 member 2	A0A6I8RHZ8 A0A6I8SBL4 B0JZG0 B3DLY4 F7DHZ9 Q0P4X7 Q28EA4 Q5PPQ3 Q6DET4	LOC100170571 LOC100498331 LOC100498493 LOC548733 MGC89704 cyb5 cyb5a cyb5r3 glut1 gsto1 gsto2 ped slc23a1 slc23a2 slc2a1 slc2a14 slc2a3	Xenopus tropicalis (tropical clawed frog)
Mitochondrial ABC transporters	ATP-binding cassette sub-family B member 6 Iron-sulfur clusters transporter ABCB7, mitochondrial	A0A6I8STI5 Q08D64	abcb6 abcb7	Xenopus tropicalis (tropical clawed frog)
CS/DS degradation	Alpha-L-iduronidase Beta-hexosaminidase Biglycan Brevican core protein Chondroitin sulfate proteoglycan 5 Hyaluronidase Iduronate 2-sulfatase Neurocan Versican core protein	A0A6I8QUP1 A0A6I8RTQ2 A0A6I8SI02 A0A6I8SP25 A0A803JXD8 B1H351 F6YUS7 F7CIX8 Q0P4I3	LOC100145556 MGC147411 PGI bcan bgn cspg5 dspg1 enc-1as hexb hyal1 ids idua mps2 ncan pg-s1 sids slrr1a vcan xbgn	Xenopus tropicalis (tropical clawed frog)	G27025MB
PI3K/AKT Signaling	3-phosphoinositide-dependent protein kinase 1 Amphiregulin Beta-klotho Betacellulin Butyrophilin-like protein 10 CD80 molecule Cytotoxic T-lymphocyte protein 4 Estrogen receptor beta Estrogen receptor Fibroblast growth factor 23 Fibroblast growth factor 23 Fibroblast growth factor receptor substrate 2 Fibroblast growth factor receptor Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor GRB2-associated-binding protein 1 GRB2-associated-binding protein 2 Growth factor receptor-bound protein 2 Hepatocyte growth factor receptor Hepatocyte growth factor Inducible T-cell costimulator Insulin receptor substrate 1 Insulin receptor substrate 2 Kit ligand Klotho LOC100127663 protein Mast/stem cell growth factor receptor Multifunctional fusion protein Novel protein similar to ras-related C3 botulinum toxin substrate 1 (Rho family, small GTP binding protein Rac1) Phosphatidylinositol 3-kinase regulatory subunit alpha Phosphatidylinositol 3-kinase regulatory subunit beta Phosphatidylinositol 3-kinase regulatory subunit gamma Platelet-derived growth factor receptor alpha Platelet-derived growth factor subunit B Proheparin-binding EGF-like growth factor Ras homolog family member G Ras-related C3 botulinum toxin substrate 1 Receptor protein-tyrosine kinase Receptor protein-tyrosine kinase Striatin T-lymphocyte activation antigen CD86 Tyrosine-protein kinase Tyrosine-protein phosphatase non-receptor type phosphatidylinositol-4,5-bisphosphate 3-kinase phosphatidylinositol-4,5-bisphosphate 3-kinase receptor protein-tyrosine kinase receptor protein-tyrosine kinase	A0A6I8PM12 A0A6I8Q186 A0A6I8Q702 A0A6I8Q964 A0A6I8QCY1 A0A6I8QGX4 A0A6I8QXV8 A0A6I8QZN8 A0A6I8R0X7 A0A6I8R680 A0A6I8R8T1 A0A6I8RD47 A0A6I8RF66 A0A6I8RSV6 A0A6I8SAV8 A0A6I8SCF3 A0A6I8SGM2 A0A6I8SJT2 A0A6I8SLH0 A0A7D9NJV5 A0A7D9NL28 A0A803J293 A0A803JX37 A0A803JX40 A0A803K1Y5 A0A803K518 A0A803KIA6 A4IHL2 A8KBG4 B0BLW6 B1H1E3 B4F6K4 B4F6V0 B5DE89 B7U3X7 B7U3X8 B7U4G3 B7UC02 B7ZSQ9 F6UFM4 F6VBJ9 F6XSB5 F6Z0J4 F6ZB49 F6ZBI8 F7CD16 Q0IHS8 Q25C13 Q28DZ3 Q28GC1 Q28IS1 Q28J96 Q5M8J2 Q66IF7 Q66II3 Q6GL60 Q6W5G9	ERalpha ERbeta FGF-8 HBGF-1 HBGF-2 HBGF-4 INT-2 LOC100124862 LOC100127663 LOC100144924 LOC100145251 LOC100489320 LOC100493997 LOC100498409 PI3-kinase PI3K-alpha Rac1 X1FGFR XEFGF XER XFGFR-1 XFGFR-4 XFGFR-4a XSNT Xfgf-4 Xfgf-8 Xfgf4 Xfgf8 Xkl-1 Xrac Xsl Xsl-1 Xsl-2 Xstriatin aFGF aigf areg bfgf bfgfr btc btnl10 c-kit c-sis cd331 cd334 cd80 cd86 cek ctla4 ecgf ecgf-beta ecgfa ecgfb efgf egf egfr en-7 er-beta era erb erbb4 esr esr-beta esr1 esr1-a esr1-b esr2 esra esrb estrb fgf-1 fgf-10 fgf-19 fgf-2 fgf-3 fgf-4 fgf-6 fgf-8b fgf-alpha fgf1 fgf10 fgf16 fgf19 fgf2 fgf22 fgf23.1 fgf23.2 fgf3 fgf4 fgf4-a fgf4-b fgf5 fgf6 fgf8 fgf8a fgf8b fgf9 fgfa fgfb fgfbr fgfe fgfr-1 fgfr-4 fgfr1 fgfr1-a fgfr1-b fgfr4 fgfr4-a fgfr4-b flg flt-2 flt2 flt3 frs2 frs2a frs2alpha fyn gab1 gab2 glio703 grb2 hbegf hbgf-3 hbgf-6 hbgf-8 hbgf1 hbgfr hbgh-2 hgf hspc022 hst hst-1 hst2 hstf1 icos int2 irs1 jtk2 k-fgf kal2 kfgf kit kit-a kit-b kitl kitlg kl kl-1 klb krk1 met mgf mig5 n-sam nr3a1 nr3a2 ogd p110-beta p21-rac1 p55 p55-gamma pbt pdgf2 pdgfb pdgfr-alpha pdgfr2 pdgfra pdgfralpha pdgfrb pdpk1 pi3-k pi3k pi3k92e pi3kbeta pik3c1 pik3ca pik3cb pik3r1 pik3r2 pik3r3 ptpn11 rac rac1 rac2 rhog scf scfr sis snt snt-1 snt1 steel strn tc-25 tkf xegf xesr-1 xesr1 xfgf2 xfgf3 xfgfr1 xfgfr4 xfrs2 xkl-1 xlERalpha1 xlERalpha2 xsrf2	Xenopus tropicalis (tropical clawed frog)
Amino acids regulate mTORC1	ATPase, H+ transporting, V0 subunit B ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E Chromosome 12 open reading frame 66KICSTOR subunit 2 Cytosolic arginine sensor for mTORC1 subunit 1 Cytosolic arginine sensor for mTORC1 subunit 2 DEP domain containing 5 Folliculin-interacting protein 1 Folliculin-interacting protein 2 isoform X1 Folliculin GATOR complex protein MIOS GATOR complex protein NPRL3 GATOR complex protein WDR59 isoform X1 GATOR2 complex protein WDR24 GTP-binding protein Rheb H(+)-transporting two-sector ATPase Integrin-alpha FG-GAP repeat-containing protein 2 Neutral amino acid transporter 9 Nucleoporin SEH1 Protein SEC13 homolog Ragulator complex protein LAMTOR1 Ragulator complex protein LAMTOR2 Ragulator complex protein LAMTOR3 Ragulator complex protein LAMTOR4 Ragulator complex protein LAMTOR5 Ras-related GTP-binding protein Ras-related GTP-binding protein Regulatory-associated protein of MTOR, complex 1 SH3 domain-binding protein 4 Sesn1 protein Target of rapamycin complex subunit lst8 V-type proton ATPase proteolipid subunit V-type proton ATPase subunit C 1 V-type proton ATPase subunit C V-type proton ATPase subunit F V-type proton ATPase subunit G 3 V-type proton ATPase subunit G V-type proton ATPase subunit H V-type proton ATPase subunit a V-type proton ATPase subunit d 2 V-type proton ATPase subunit V-type proton ATPase subunit Vacuolar proton pump subunit B Vacuolar proton pump subunit B	A0A6I8QVB6 A0A6I8R4V3 A0A6I8RIN4 A0A6I8RRW4 A0A6I8SSI7 A0A803JPN5 A0JLY8 A4IJ18 A4QNE9 A9UL91 A9UMU8 B0BM81 B0BMI3 B3DLB2 B4F6J0 B4F6T9 B4F6Y3 B7ZST5 B7ZSW8 F6Y9T5 F6YL50 F7AU31 Q0VFL0 Q0VGW2 Q28DM4 Q5BJ49 Q5I0B4 Q5M7Q1 Q5M7S0 Q5U228 Q5U4Y8 Q63ZZ8 Q68F94 Q6DF40 Q6DFN3 Q6DIZ5 Q6GLA8 Q6P2W7 Q6P335 Q6P4Y9 Q6P812 Q6P8D7 Q6PBE9	LOC100125101 LOC100144985 MGC76017 MGC89120 Vma7 XPA26 a3 atp6a1 atp6b1 atp6c atp6e atp6f atp6h atp6i atp6l atp6s14 atp6v0b atp6v0c atp6v0d1 atp6v0d2 atp6v0e atp6v0e1 atp6v1a atp6v1a1 atp6v1b1 atp6v1b2 atp6v1c1 atp6v1c2 atp6v1e atp6v1e1 atp6v1f atp6v1f-a atp6v1f-b atp6v1g1 atp6v1g3 atp6v1h atpl atpv1a ba11d8.2.1 c12orf66 c16orf35 castor1 castor2 cgthba depdc5 ductin flcn fnip1 fnip2 gatsl1 gatsl2 gatsl3 gbl hatpl hbxip ho68 hs-40 itfg2 kics2 lamtor1 lamtor2 lamtor3 lamtor4 lamtor5 lst8 m9.2 mapksp1 mare mios mlst8 npr3 nprl3 oc116 optb1 pa26 ragd raptor rheb rheb2 rmd11 robld3 rptor rraga rragc rragd rta1b sec13 sec13l1 seh1l sesn1 sest1 sh3bgrl sh3bp4 slc38a9 tbc1d24.1 tcirg1 tirc7 v1a va68 vatb vatf vatl vha55 vma1 vma16 vma2 vma21 vma21p vma3 vma4 vph1 vpp2 vpp3 wdr24 wdr59 xduct	Xenopus tropicalis (tropical clawed frog)
NOTCH2 intracellular domain regulates transcription	Mastermind like transcriptional coactivator 1 Mastermind-like domain-containing 1 Mastermind-like protein 2 Mastermind-like protein 3 isoform X1 Neurogenic locus notch homolog protein 1 Recombination signal binding protein for immunoglobulin kappa J region	A0A6I8Q1E9 A0A7D9NMC8 A0A803J8V4 A0A803JE16 A2RUV0 F7C5X6	maml1 maml2 maml3 mamld1 notch1 rbpj	Xenopus tropicalis (tropical clawed frog)
Elevation of cytosolic Ca2+ levels	Inositol 1,4,5-trisphosphate receptor (Fragment) Inositol 1,4,5-trisphosphate receptor P2X purinoceptor P2X purinoceptor P2X purinoceptor Short transient receptor potential channel 3 Short transient receptor potential channel 6 isoform X1	A0A6I8RGU0 A0A6I8RW96 A0A6I8SDW5 A0A6I8SK99 A0A803JVP3 A4ZYX8 F6V4A4	itpr2 itpr3 p2rx1 p2rx4 p2rx5 trpc3 trpc6	Xenopus tropicalis (tropical clawed frog)
Phospholipase C-mediated cascade: FGFR1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma Fibroblast growth factor 23 Fibroblast growth factor 23 Fibroblast growth factor receptor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Fibroblast growth factor Klotho Multifunctional fusion protein	A0A6I8PM12 A0A6I8SJT2 A0A803J293 A0A803K518 A0A803KIA6 B7U3X7 B7U3X8 B7UC02 B7ZSQ9 F6XSB5 F6Z8A1 F6ZB49 Q28DZ3 Q28J96 Q66IF7	FGF-8 HBGF-1 HBGF-2 HBGF-4 INT-2 X1FGFR XEFGF XFGFR-1 Xfgf-4 Xfgf-8 Xfgf4 Xfgf8 aFGF aigf bfgf bfgfr cd331 cek ecgf ecgf-beta ecgfa ecgfb efgf fgf-1 fgf-10 fgf-2 fgf-3 fgf-4 fgf-6 fgf-8b fgf-alpha fgf1 fgf10 fgf2 fgf22 fgf23.1 fgf23.2 fgf3 fgf4 fgf4-a fgf4-b fgf5 fgf6 fgf8 fgf8a fgf8b fgf9 fgfa fgfb fgfbr fgfe fgfr-1 fgfr1 fgfr1-a fgfr1-b flg flt-2 flt2 glio703 hbgf-3 hbgf-6 hbgf-8 hbgf1 hbgfr hbgh-2 hst hst-1 hst2 hstf1 int2 k-fgf kal2 kfgf kl n-sam ogd plcg1 xfgf2 xfgf3 xfgfr1	Xenopus tropicalis (tropical clawed frog)

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