23148226

Summary
Title
Heparin oligosaccharides inhibit chemokine (CXC motif) ligand 12 (CXCL12) cardioprotection by binding orthogonal to the dimerization interface, promoting oligomerization, and competing with the chemokine (CXC motif) receptor 4 (CXCR4) N terminus.
Authors
  • Ziarek JJ
  • Veldkamp CT
  • Zhang F
  • Murray NJ
  • Kartz GA
  • Liang X
  • Su J
  • Baker JE
  • Linhardt RJ
  • Volkman BF
Source
J Biol Chem
Publication Date
2013 Jan 4
PubMed ID
23148226

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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