Lewy body dementia

Summary
Synonym
  • Dementia with Lewy bodies
  • Diffuse Lewy body disease
  • Lewy body disease
  • Senile dementia of the Lewy body type
Definition
A dementia that is characterized by the development of abnormal proteinaceous (alpha-synuclein) cytoplasmic inclusions, called Lewy bodies, throughout the brain that results in progressive decline in mental abilities.
Super Class
dementia
External Links
Disease Ontology
DOID:12217
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
OMIM
GARD
MGI genotype (from TogoID)
WikiPathways (from TogoID)
Related Genes
Displaying entries 1 - 10 of 28 in total
Gene ID Gene Symbol Description Source
43 ACHE acetylcholinesterase (Yt blood group)
308 ANXA5 annexin A5
427 ASAH1 N-acylsphingosine amidohydrolase 1
1116 CHI3L1 chitinase 3 like 1
1312 COMT catechol-O-methyltransferase
1555 CYP2B6 cytochrome P450 family 2 subfamily B member 6
1636 ACE angiotensin I converting enzyme
1738 DLD dihydrolipoamide dehydrogenase
2026 ENO2 enolase 2
2053 EPHX2 epoxide hydrolase 2
Displaying all 3 entries
Gene ID Gene Symbol Description Source
14466 Gba1 glucosylceramidase beta 1
16002 Igf2 insulin-like growth factor 2
18538 Pcna proliferating cell nuclear antigen
Displaying all 2 entries
Gene ID Gene Symbol Description Source
24483 Igf2 insulin-like growth factor 2
25737 Pcna proliferating cell nuclear antigen
Displaying all 4 entries
Gene ID Gene Symbol Description Source
173574 gba-1 Putative glucosylceramidase 1
177314 gba-4 Putative glucosylceramidase 4
178535 gba-3 Putative glucosylceramidase 3
183155 gba-2 Putative glucosylceramidase 2
Related Glycoprotein
The Human Phenotype Ontology
Displaying all 7 entries
HPO ID HPO Term
HP:0001300 Parkinsonism
HP:0000726 Dementia
HP:0007159 Fluctuations in consciousness
HP:0000006 Autosomal dominant inheritance
HP:0002367 Visual hallucination
HP:0100315 Lewy bodies
HP:0000746 Delusion
Displaying 1 entry
Gene ID Gene Symbol Description
2629 GBA1 glucosylceramidase beta 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024