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MIRAGE
mucopolysaccharidosis III
Summary
- Synonym
-
- Mucopolysaccharidosis, MPS-III
- N-sulphoglucosamine sulphohydrolase deficiency
- Sanfilippo's syndrome
- heparan sulfate sulfatase deficiency
- Definition
- A mucopolysaccharidosis characterized by a deficiency of the lysosomal enzyme resulting in incomplete breakdown of the heparan sulfate sugar chain.
- Super Class
- mucopolysaccharidosis
Related Genes
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P15586 | N-acetylglucosamine-6-sulfatase | |
| P51688 | N-sulphoglucosamine sulphohydrolase | |
| P54802 | Alpha-N-acetylglucosaminidase |
| UniProt ID | Protein Name | Source |
|---|---|---|
| O88325 | Alpha-N-acetylglucosaminidase | |
| Q3UDW8 | Heparan-alpha-glucosaminide N-acetyltransferase | |
| Q6PCZ1 | Gns protein | |
| Q9EQ08 | Heparan N-sulfatase |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0001260 | Dysarthria |
| HP:0001263 | Global developmental delay |
| HP:0001272 | Cerebellar atrophy |
| HP:0001344 | Absent speech |
| HP:0001348 | Brisk reflexes |
| HP:0001385 | Hip dysplasia |
| HP:0001387 | Joint stiffness |
| HP:0001507 | Growth abnormality |
| HP:0001653 | Mitral regurgitation |
| HP:0001670 | Asymmetric septal hypertrophy |
