Submissions
GlyTouCan
Glycan Structure Repository
GlyComb
Glycoconjugate Repository
GlycoPOST
Glycomics MS raw data Repository
UniCarb-DR
Glycomics MS Repository for glycan annotations from GlycoWorkbench
LM-GlycoRepo
Repository for lectin-assisted multimodality data
All Resources
Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 1543 | CYP1A1 | cytochrome P450 family 1 subfamily A member 1 | |
| 1544 | CYP1A2 | cytochrome P450 family 1 subfamily A member 2 | |
| 1571 | CYP2E1 | cytochrome P450 family 2 subfamily E member 1 | |
| 1636 | ACE | angiotensin I converting enzyme | |
| 1672 | DEFB1 | defensin beta 1 | |
| 1906 | EDN1 | endothelin 1 | |
| 1956 | EGFR | epidermal growth factor receptor | |
| 1958 | EGR1 | early growth response 1 | |
| 2006 | ELN | elastin | |
| 2065 | ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 18979 | Pon1 | paraoxonase 1 | |
| 19017 | Ppargc1a | peroxisome proliferative activated receptor, gamma, coactivator 1 alpha | |
| 19225 | Ptgs2 | prostaglandin-endoperoxide synthase 2 | |
| 20290 | Ccl1 | C-C motif chemokine ligand 1 | |
| 20292 | Ccl11 | C-C motif chemokine ligand 11 | |
| 20296 | Ccl2 | C-C motif chemokine ligand 2 | |
| 20306 | Ccl7 | C-C motif chemokine ligand 7 | |
| 20344 | Selp | selectin, platelet | |
| 20388 | Sftpb | surfactant associated protein B | |
| 20390 | Sftpd | surfactant associated protein D |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24232 | C3 | complement C3 | |
| 24255 | Cftr | CF transmembrane conductance regulator | |
| 24260 | Chrm3 | cholinergic receptor, muscarinic 3 | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24297 | Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24407 | Grik5 | glutamate ionotropic receptor kainate type subunit 5 | |
| 24410 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | |
| 24464 | Hp | haptoglobin | |
| 24536 | Lepr | leptin receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31926 | Idgf4 | Imaginal disc growth factor 4 | |
| 34091 | Spn28Dc | Serpin 28Dc | |
| 34189 | Acer | Angiotensin-converting enzyme-related | |
| 34304 | nAChRalpha6 | nicotinic Acetylcholine Receptor alpha6 | |
| 34805 | Ance | Angiotensin converting enzyme | |
| 34978 | Idgf1 | Imaginal disc growth factor 1 | |
| 34979 | Idgf2 | Imaginal disc growth factor 2 | |
| 34981 | Idgf3 | Imaginal disc growth factor 3 | |
| 36868 | Idgf6 | Imaginal disc growth factor 6 | |
| 37104 | Idgf5 | Imaginal disc growth factor 5 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 447803 | pon1 | paraoxonase 1 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| 559080 | cftr | CF transmembrane conductance regulator | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 791973 | cxcr3.2 | chemokine (C-X-C motif) receptor 3, tandem duplicate 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 399298 | ntf3.L | neurotrophin 3 L homeolog | Xenopus laevis (African clawed frog) | |
| 448598 | pon2 | paraoxonase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 108697308 | adrb1.L | adrenoceptor beta 1 L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 178269 | lev-1 | Acetylcholine receptor subunit beta-type lev-1 | |
| 178672 | srp-3 | Serpin domain-containing protein | |
| 179197 | cri-2 | Putative metalloproteinase inhibitor tag-225 | |
| 179235 | acr-16 | Acetylcholine receptor subunit alpha-type acr-16 | |
| 179962 | gar-3 | Muscarinic acetylcholine receptor gar-3 | |
| 179991 | zmp-4 | Hemopexin;Peptidase metallopeptidase domain-containing protein | |
| 180289 | mrp-7 | Multidrug resistance protein mrp-7 | |
| 180351 | W01F3.2 | Uncharacterized protein | |
| 180408 | mrp-2 | Multidrug resistance-associated protein 1 | |
| 180409 | mrp-1 | Multidrug resistance-associated protein 1 |
