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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
chronic obstructive pulmonary disease
Summary
- Synonym
-
- COLD
- COPD
- chronic obstructive airway disease
- chronic obstructive lung disease
- Definition
- An obstructive lung disease that is a chronic and progressive disorder of small airways in the lungs and that is characterized by irreversible airflow obstruction, typically identified by reductions in quantitative spirometric indices, induced forced expiratory volume at 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (less than 0.7 is diagnostic of COPD). Lung volume is increased and pulmonary hypertension may occur. The pathologic changes result in the disruption of the airflow in the bronchial airways. Signs and symptoms include shortness of breath, wheezing, productive cough and chest tightness. COPD is a consequence (an end result) of chronic bronchitis, emphysema or both.
- Super Class
- obstructive lung disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 1543 | CYP1A1 | cytochrome P450 family 1 subfamily A member 1 | |
| 1544 | CYP1A2 | cytochrome P450 family 1 subfamily A member 2 | |
| 1571 | CYP2E1 | cytochrome P450 family 2 subfamily E member 1 | |
| 1636 | ACE | angiotensin I converting enzyme | |
| 1672 | DEFB1 | defensin beta 1 | |
| 1906 | EDN1 | endothelin 1 | |
| 1956 | EGFR | epidermal growth factor receptor | |
| 1958 | EGR1 | early growth response 1 | |
| 2006 | ELN | elastin | |
| 2065 | ERBB3 | erb-b2 receptor tyrosine kinase 3 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 20657 | Sod3 | superoxide dismutase 3, extracellular | |
| 20700 | Serpina1a | serine (or cysteine) peptidase inhibitor, clade A, member 1A | |
| 20701 | Serpina1b | serine (or cysteine) preptidase inhibitor, clade A, member 1B | |
| 20702 | Serpina1c | serine (or cysteine) peptidase inhibitor, clade A, member 1C | |
| 20703 | Serpina1d | serine (or cysteine) peptidase inhibitor, clade A, member 1D | |
| 20704 | Serpina1e | serine (or cysteine) peptidase inhibitor, clade A, member 1E | |
| 20714 | Serpina3k | serine (or cysteine) peptidase inhibitor, clade A, member 3K | |
| 20716 | Serpina3n | serine (or cysteine) peptidase inhibitor, clade A, member 3N | |
| 20717 | Serpina3m | serine (or cysteine) peptidase inhibitor, clade A, member 3M | |
| 21803 | Tgfb1 | transforming growth factor, beta 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24232 | C3 | complement C3 | |
| 24255 | Cftr | CF transmembrane conductance regulator | |
| 24260 | Chrm3 | cholinergic receptor, muscarinic 3 | |
| 24296 | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | |
| 24297 | Cyp1a2 | cytochrome P450, family 1, subfamily a, polypeptide 2 | |
| 24310 | Ace | angiotensin I converting enzyme | |
| 24407 | Grik5 | glutamate ionotropic receptor kainate type subunit 5 | |
| 24410 | Grin2b | glutamate ionotropic receptor NMDA type subunit 2B | |
| 24464 | Hp | haptoglobin | |
| 24536 | Lepr | leptin receptor |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 30682 | vegfaa | vascular endothelial growth factor Aa | |
| 447803 | pon1 | paraoxonase 1 | |
| 554230 | kdr | kinase insert domain receptor (a type III receptor tyrosine kinase) | |
| 559080 | cftr | CF transmembrane conductance regulator | |
| 565980 | ace | angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 | |
| 791973 | cxcr3.2 | chemokine (C-X-C motif) receptor 3, tandem duplicate 2 |
| Gene ID | Gene Symbol | Description | Source | Organism |
|---|---|---|---|---|
| 373580 | crhr1.2.S | corticotropin releasing hormone receptor 1, gene 2 S homeolog | Xenopus laevis (African clawed frog) | |
| 397778 | tgfb1.L | transforming growth factor beta 1 L homeolog | Xenopus laevis (African clawed frog) | |
| 399298 | ntf3.L | neurotrophin 3 L homeolog | Xenopus laevis (African clawed frog) | |
| 448598 | pon2 | paraoxonase 2 | Xenopus tropicalis (tropical clawed frog) | |
| 100144634 | ace | angiotensin I converting enzyme | Xenopus tropicalis (tropical clawed frog) | |
| 108697308 | adrb1.L | adrenoceptor beta 1 L homeolog | Xenopus laevis (African clawed frog) |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 171999 | poml-2 | Arylesterase | |
| 172105 | unc-38 | Acetylcholine receptor subunit alpha-type unc-38 | |
| 172150 | unc-63 | Acetylcholine receptor subunit alpha-type unc-63 | |
| 172449 | glr-3 | Glutamate receptor ionotropic, kainate glr-3 | |
| 174262 | acr-7 | Acetylcholine receptor subunit alpha-type acr-7 | |
| 174462 | let-23 | Receptor tyrosine-protein kinase let-23;receptor protein-tyrosine kinase | |
| 175072 | eat-2 | Neuronal acetylcholine receptor subunit eat-2 | |
| 175182 | ver-1 | Protein ver-1 | |
| 175383 | zmp-2 | Matrix metalloproteinase-B | |
| 177343 | skn-1 | BZIP domain-containing protein;Protein skinhead-1 |
