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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Leigh disease
Summary
- Synonym
-
- Infantile necrotizing encephalomyelopathy
- Leigh syndrome
- juvenile subacute necrotizing encephalomyelopathy
- Definition
- A cytochrome-c oxidase deficiency disease characterized by progressive loss of mental and movement abilities. Symptoms usually begin between ages of three months and two years and include loss of appetite, vomiting, irritability and seizure activity.
- Super Class
- cytochrome-c oxidase deficiency disease
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 4537 | ND3 | NADH dehydrogenase subunit 3 | |
| 4540 | ND5 | NADH dehydrogenase subunit 5 | |
| 6389 | SDHA | succinate dehydrogenase complex flavoprotein subunit A | |
| 6391 | SDHC | succinate dehydrogenase complex subunit C | |
| 6648 | SOD2 | superoxide dismutase 2 | |
| 6834 | SURF1 | SURF1 cytochrome c oxidase assembly factor | |
| 10128 | LRPPRC | leucine rich pentatricopeptide repeat containing |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 17721 | ND5 | NADH dehydrogenase subunit 5 | |
| 17993 | Ndufs4 | NADH:ubiquinone oxidoreductase core subunit S4 | |
| 20656 | Sod2 | superoxide dismutase 2, mitochondrial | |
| 66052 | Sdhc | succinate dehydrogenase complex, subunit C, integral membrane protein | |
| 72416 | Lrpprc | leucine-rich PPR-motif containing | |
| 225887 | Ndufs8 | NADH:ubiquinone oxidoreductase core subunit S8 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24787 | Sod2 | superoxide dismutase 2 | |
| 157074 | Sdha | succinate dehydrogenase complex flavoprotein subunit A | |
| 192241 | Atp5po | ATP synthase peripheral stalk subunit OSCP | |
| 289218 | Ndufs2 | NADH:ubiquinone oxidoreductase core subunit S2 | |
| 293652 | Ndufs8 | NADH:ubiquinone oxidoreductase core subunit S8 | |
| 316632 | Ndufa10l1 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1 | |
| 499529 | Ndufs4 | NADH:ubiquinone oxidoreductase subunit S4 | |
| 678759 | Ndufa10 | NADH:ubiquinone oxidoreductase subunit A10 |
