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SURF1 cytochrome c oxidase assembly factor

Summary

Gene Symbol

SURF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6834

PubChem

6834

Alliance of Genome Resources

HGNC:11474

JoGo

SURF1

TogoVar

SURF1

Annotation

Keyword

Alternative splicing
Charcot-Marie-Tooth disease
Disease variant
Leigh syndrome
Mitochondrion inner membrane
Neurodegeneration
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q15526
A0A087WYS9
E5KRX5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
respiratory chain complex IV assembly	TAS	9843204
aerobic respiration	TAS	9843204
mitochondrial cytochrome c oxidase assembly	IMP	24027061
mitochondrial cytochrome c oxidase assembly	IBA
proton transmembrane transport	IEA

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

cellular respiration [inference]

aerobic respiration

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex IV assembly

mitochondrial cytochrome c oxidase assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial cytochrome c oxidase assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

cytochrome complex assembly [inference]

respiratory chain complex IV assembly

mitochondrial cytochrome c oxidase assembly

mitochondrial respiratory chain complex assembly [inference]

mitochondrial cytochrome c oxidase assembly

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

proton transmembrane transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
mitochondrion	IBA
mitochondrion	HTP	34800366
mitochondrial inner membrane	TAS
respiratory chain complex	TAS	9843204

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

respiratory chain complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytochrome-c oxidase activity	IEA
protein binding	IPI	23260140 26321642

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

electron transfer activity [inference]

cytochrome-c oxidase activity

oxidoreductase activity, acting on a heme group of donors [inference]

cytochrome-c oxidase activity

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

oxidoreduction-driven active transmembrane transporter activity [inference]

cytochrome-c oxidase activity

active monoatomic ion transmembrane transporter activity [inference]

cytochrome-c oxidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Surfeit 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
Golgi organization
mitochondrial cytochrome c oxidase assembly

Displaying **all 2** entries
InterPro
Surfeit locus 1/4
Surfeit locus 1/Shy1

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0070491	mitochondrial complex IV deficiency nuclear type 1	Alliance of Genome Resources
DOID:0110187	Charcot-Marie-Tooth disease type 4K	Alliance of Genome Resources
DOID:3652	Leigh disease	Alliance of Genome Resources