Crigler-Najjar syndrome

Summary
Synonym
  • Bilirubin UDP glucuronyl transferase deficiency
  • Crigler Najjar syndrome
  • Crigler-Najjar syndrome, type I
Definition
A bilirubin metabolic disorder that involves a build up of bilirubin as bilirubin is not being broken down as a result of a lack or deficiency of the enzyme uridine diphosphate glycosyltransferase (UGT).
Super Class
bilirubin metabolic disorder
Disease Ontology
DOID:3803
Mondo Disease Ontology
MeSH
UMLS
ORDO
OMIM
MGI genotype (from TogoID)
Related Genes
Displaying 1 entry
Gene ID Gene Symbol Description Source
54658 UGT1A1 UDP glucuronosyltransferase family 1 member A1
Displaying 1 entry
Gene ID Gene Symbol Description Source
394436 Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1
Displaying 1 entry
Gene ID Gene Symbol Description Source
24861 Ugt1a1 UDP glucuronosyltransferase family 1 member A1
Displaying entries 11 - 20 of 20 in total
Gene ID Gene Symbol Description Source
44058 Ugt36A1 UDP-glycosyltransferase family 36 member A1
53501 Ugt304A1 UDP-glycosyltransferase family 304 member A1
53502 Ugt302K1 UDP-glycosyltransferase family 302 member K1
53503 Ugt303A1 UDP-glycosyltransferase family 303 member A1
53506 Ugt35E2 UDP-glycosyltransferase family 35 member E2
53507 Ugt35C1 UDP-glycosyltransferase family 35 member C1
53511 Ugt37D1 UDP-glycosyltransferase family 37 member D1
53512 Ugt37E1 UDP-glycosyltransferase family 37 member E1
53583 Ugt37C1 UDP-glycosyltransferase family 37 member C1
53584 Ugt37B1 UDP-glycosyltransferase family 37 member B1
Displaying all 2 entries
Gene ID Gene Symbol Description Source
406731 ugt1ab UDP glucuronosyltransferase 1 family a, b
100384891 ugt1a7 UDP glucuronosyltransferase 1 family, polypeptide A7
Displaying all 2 entries
Gene ID Gene Symbol Description Source Organism
100135191 ugt1a6 UDP glucuronosyltransferase 1 family, polypeptide A6 Xenopus tropicalis (tropical clawed frog)
100489505 ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 Xenopus tropicalis (tropical clawed frog)
Displaying all 4 entries
Gene ID Gene Symbol Description Source
172085 ugt-26 UDP-glucuronosyltransferase
175591 ugt-62 UDP-glucuronosyltransferase
178330 ugt-22 UDP-glucuronosyltransferase
185500 ugt-61 UDP-glucuronosyltransferase
Displaying 1 entry
Gene ID Gene Symbol Description Source
850886 ATG26 sterol 3-beta-glucosyltransferase
The Human Phenotype Ontology
Displaying entries 11 - 19 of 19 in total
HPO ID HPO Term
HP:0001080 Biliary tract abnormality
HP:0008947 Infantile muscular hypotonia
HP:0001250 Seizure
HP:0002354 Memory impairment
HP:0000952 Jaundice
HP:0003577 Congenital onset
HP:0000007 Autosomal recessive inheritance
HP:0002910 Elevated circulating hepatic transaminase concentration
HP:0001298 Encephalopathy
Displaying 1 entry
Gene ID Gene Symbol Description
54658 UGT1A1 UDP glucuronosyltransferase family 1 member A1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: December 9, 2024