progressive multifocal leukoencephalopathy

Summary
Definition
A viral infectious disease that involves reactivation of JC polyomavirus in immune-compromised individuals which causes the loss of white matter (which is made up of myelin, a substance the surrounds and protects nerve fibers) in multiple areas of the brain. The symptoms include hemiparesis, aphasia, dysarthria, hemianopia, cognitive impairment and coma.
Super Class
viral infectious disease
External Links
Disease Ontology
DOID:643
Mondo Disease Ontology
MeSH
UMLS
NCI Thesaurus
GARD
Related Genes
Displaying entries 1 - 10 of 11 in total
Gene ID Gene Symbol Description Source
142 PARP1 poly(ADP-ribose) polymerase 1
416 ARSF arylsulfatase F
847 CAT catalase
929 CD14 CD14 molecule
2571 GAD1 glutamate decarboxylase 1
5329 PLAUR plasminogen activator, urokinase receptor
5621 PRNP prion protein (Kanno blood group)
5660 PSAP prosaposin
6342 SCP2 sterol carrier protein 2
6646 SOAT1 sterol O-acyltransferase 1

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024