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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
obesity
Summary
- Definition
- An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness.
- Super Class
- overnutrition
External Links
- Disease Ontology
- DOID:9970
- Mondo Disease Ontology
- MeSH
- UMLS
- NCI Thesaurus
- OMIM
- MGI genotype (from TogoID)
-
- 3766125
- 3821619
- 3821616
- 3817475
- 3799316
- 3784993
- 3784991
- 3773447
- 3772367
- 3822317
- 3766122
- 3721145
- 3715252
- 3694548
- 3689720
- 3664551
- 3664276
- 3655835
- 5515728
- 7545554
- 7545550
- 7545546
- 6273993
- 5828524
- 5766495
- 5763310
- 5763241
- 3655832
- 5447549
- 5300906
- 3850836
- 3847120
- 3840234
- 3832410
- 3822318
- 3033164
- 3511746
- 3055585
- 3055584
- 3053798
- 3041643
- 3036853
- 3036852
- 3033165
- 3511747
- 2681522
- 2680503
- 2669229
- 2663736
- 2654708
- 2653295
- 2651886
- 2388265
- 3589409
- 3655811
- 3639781
- 3639355
- 3639354
- 3629805
- 3623749
- 3620067
- 3611807
- 2174793
- 3586756
- 3582615
- 3580003
- 3579026
- 3577766
- 3526863
- 3511748
- WikiPathways (from TogoID)
Related Genes
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 5106 | PCK2 | phosphoenolpyruvate carboxykinase 2, mitochondrial | |
| 5167 | ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | |
| 5168 | ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | |
| 5209 | PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | |
| 5214 | PFKP | phosphofructokinase, platelet | |
| 5290 | PIK3CA | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha | |
| 5291 | PIK3CB | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta | |
| 5293 | PIK3CD | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta | |
| 5294 | PIK3CG | phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma | |
| 5310 | PKD1 | polycystin 1, transient receptor potential channel interacting |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 59027 | Nampt | nicotinamide phosphoribosyltransferase | |
| 68054 | Serpina12 | serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | |
| 72774 | Neil1 | nei endonuclease VIII-like 1 (E. coli) | |
| 103988 | Gck | glucokinase | |
| 105787 | Prkaa1 | protein kinase, AMP-activated, alpha 1 catalytic subunit | |
| 230796 | Wdtc1 | WD and tetratricopeptide repeats 1 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 24267 | Comt | catechol-O-methyltransferase | |
| 24377 | G6pd | glucose-6-phosphate dehydrogenase | |
| 24383 | Gapdh | glyceraldehyde-3-phosphate dehydrogenase | |
| 24385 | Gck | glucokinase | |
| 24536 | Lepr | leptin receptor | |
| 24577 | Myc | MYC proto-oncogene, bHLH transcription factor | |
| 24835 | Tnf | tumor necrosis factor | |
| 25058 | Hk1 | hexokinase 1 | |
| 25059 | Hk2 | hexokinase 2 | |
| 25233 | Akt2 | AKT serine/threonine kinase 2 |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 31293 | N | Notch | |
| 32545 | Gapdh2 | Glyceraldehyde 3 phosphate dehydrogenase 2 | |
| 32974 | Zw | Zwischenferment | |
| 35728 | Gapdh1 | Glyceraldehyde 3 phosphate dehydrogenase 1 | |
| 37028 | ACOX1 | acyl-CoA oxidase 1 | |
| 37447 | Sdc | Syndecan | |
| 39404 | INPP5E | Inositol polyphosphate 5-phosphatase E | |
| 43191 | Hex-t2 | Hexokinase testis 2 | |
| 43222 | Tl | Toll | |
| 44643 | Cnx99A | Calnexin 99A |
| Gene ID | Gene Symbol | Description | Source |
|---|---|---|---|
| 850317 | GLK1 | glucokinase | |
| 850614 | HXK1 | hexokinase 1 | |
| 851974 | YPR1 | trifunctional aldehyde reductase/carbonyl reductase (NADPH)/glucose 1-dehydrogenase (NADP(+)) YPR1 | |
| 852128 | EMI2 | putative glucokinase | |
| 852639 | HXK2 | hexokinase 2 | |
| 853106 | TDH3 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH3 | |
| 853395 | TDH1 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH1 | |
| 853465 | TDH2 | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 | |
| 854287 | GCY1 | glycerol 2-dehydrogenase (NADP(+)) GCY1 | |
| 855480 | ZWF1 | glucose-6-phosphate dehydrogenase |
Related Glycoprotein
| UniProt ID | Protein Name | Source |
|---|---|---|
| P15907 | Beta-galactoside alpha-2,6-sialyltransferase 1 | |
| P16070 | CD44 antigen | |
| P16112 | Aggrecan core protein | |
| P16152 | Carbonyl reductase [NADPH] 1 | |
| P16233 | Pancreatic triacylglycerol lipase | |
| P16278 | Beta-galactosidase | |
| P16442 | Histo-blood group ABO system transferase | |
| P17405 | Sphingomyelin phosphodiesterase | |
| P17931 | Galectin-3 | |
| P18054 | Polyunsaturated fatty acid lipoxygenase ALOX12 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000007 | Autosomal recessive inheritance |
| HP:0001513 | Obesity |
| HP:0000006 | Autosomal dominant inheritance |
| HP:0010982 | Polygenic inheritance |
| HP:0012340 | Decreased resting energy expenditure |
