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Guidelines

MIRAGE

nei endonuclease VIII-like 1 (E. coli)

Summary

Gene Symbol

Neil1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72774

PubChem

72774

Alliance of Genome Resources

MGI:1920024

Annotation

Keyword

Alternative splicing
Chromosome
Cytoskeleton
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8K4Q6	DNA glycosylase/AP lyase Neil1 DNA-(apurinic or apyrimidinic site) lyase Neil1 Endonuclease VIII-like 1 Nei homolog 1 Nei-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
DNA repair	IDA	12200441
base-excision repair	ISO
base-excision repair	IBA
base-excision repair	IEA
response to oxidative stress	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

base-excision repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of macromolecule metabolic process [inference]

regulation of nuclease activity [inference]

negative regulation of nuclease activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

regulation of hydrolase activity [inference]

regulation of nuclease activity [inference]

negative regulation of nuclease activity

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IDA	12200441
nucleus	IBA
nucleoplasm	ISO
nucleoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
damaged DNA binding	IEA
DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA
zinc ion binding	IEA
hydrolase activity, acting on glycosyl bonds	ISO
lyase activity	IDA	12200441

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease 8-like 1

Functional Category

H: Coenzyme transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair
zinc ion binding

Displaying **all 2** entries
InterPro
Endonuclease VIII-like 1, DNA binding
Small ribosomal subunit protein uS13-like, H2TH

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060611	abdominal obesity-metabolic syndrome	Alliance of Genome Resources
DOID:9970	obesity	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	72774	Xenbase:XB-GENE-1013384
Homo sapiens	79661	Xenbase:XB-GENE-1013384	HUMAN24321
Rattus norvegicus	367090		RATNO41830
Danio rerio	393253		DANRE27425
Pan troglodytes	467829		PANTR10844
Bos taurus	513458		BOVIN16626
Canis lupus familiaris	611615		CANLF12712
Macaca mulatta	705484		MACMU41376
Monodelphis domestica	100030381		MONDO06873
Sus scrofa	100155341		PIGXX32024

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Last updated: December 8, 2025