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nei endonuclease VIII-like 1 (E. coli)

Summary

Gene Symbol

Neil1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

72774

PubChem

72774

Alliance of Genome Resources

MGI:1920024

Annotation

Keyword

Alternative splicing
Chromosome
Cytoskeleton
DNA repair
DNA-binding
Glycosidase
Lyase
Multifunctional enzyme
Nucleus
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q3U296
Q8K4Q6	DNA glycosylase/AP lyase Neil1 DNA-(apurinic or apyrimidinic site) lyase Neil1 Endonuclease VIII-like 1 Nei homolog 1 Nei-like protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
DNA repair	IDA	12200441
base-excision repair	ISO
base-excision repair	IBA
base-excision repair	IEA
response to oxidative stress	ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair

base-excision repair

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of macromolecule metabolic process [inference]

regulation of nuclease activity [inference]

negative regulation of nuclease activity

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nuclease activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

regulation of hydrolase activity [inference]

regulation of nuclease activity [inference]

negative regulation of nuclease activity

negative regulation of hydrolase activity [inference]

negative regulation of nuclease activity

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IDA	12200441
nucleus	IBA
nucleoplasm	ISO
nucleoplasm	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

centrosome

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

chromosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular non-membrane-bounded organelle [inference]

chromosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
damaged DNA binding	IEA
DNA-(apurinic or apyrimidinic site) endonuclease activity	IBA
zinc ion binding	IEA
hydrolase activity, acting on glycosyl bonds	ISO
lyase activity	IDA	12200441

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity

lyase activity

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease 8-like 1-like

Functional Category

H: Coenzyme transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair
endonuclease activity
zinc ion binding

Displaying **all 4** entries
InterPro
Endonuclease VIII-like 1, DNA binding
Formamidopyrimidine-DNA glycosylase, catalytic domain
MutM-like, N-terminal
Small ribosomal subunit protein uS13-like, H2TH