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phospholipase C zeta 1

Summary

Gene Symbol

PLCZ1

Organism

Monodelphis domestica (gray short-tailed opossum)

External Links

NCBI Gene: 100012056
KEGG Gene ID: mdo:100012056
PubChem: 100012056

Annotation

Keyword

Developmental protein
Fertilization
Hydrolase
Lipid degradation
Reference proteome
Transducer

Proteins

Displaying 1 entry
UniProt	Protein Name
A0A5F8G8Z9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
positive regulation of cytosolic calcium ion concentration involved in egg activation	IEA	30032202
intracellular signal transduction	IEA	22301074 30032202
lipid metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

primary metabolic process [inference]

lipid metabolic process

organic substance metabolic process [inference]

lipid metabolic process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction

reproductive process [inference]

positive regulation of cytosolic calcium ion concentration involved in egg activation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration [inference]

positive regulation of cytosolic calcium ion concentration involved in egg activation

Displaying 1 entry
GO Term	Evidence Code	PMID
nucleus	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 2** entries
GO Term	Evidence Code	PMID
phosphatidylinositol phospholipase C activity	IEA	22301074
calcium ion binding	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity [inference]

phosphatidylinositol phospholipase C activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase 1

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
lipid metabolic process
phosphatidylinositol phospholipase C activity
phosphatidylinositol-mediated signaling
release of sequestered calcium ion into cytosol

Displaying **all 7** entries
InterPro
C2 domain superfamily
C2 domain
EF-hand domain pair
PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
Phosphatidylinositol-specific phospholipase C, X domain
Phosphoinositide phospholipase C family
Phospholipase C, phosphatidylinositol-specific, Y domain

KEGG BRITE Database

Orthology

K05861

Name

phosphatidylinositol phospholipase C, zeta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Ortholog

Displaying entries **1 - 10** of 58 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	89869	HUMAN11511
Mus musculus	114875	MOUSE50099
Sus scrofa	397632	PIGXX26072
Bos taurus	497026	BOVIN30146
Rattus norvegicus	497197	RATNO31073
Macaca mulatta	703293	MACMU05194
Pan troglodytes	743002	PANTR05303
Equus caballus	100067798	HORSE35893
Taeniopygia guttata	100229724	TAEGU09372
Oryctolagus cuniculus	100359131	RABIT12207

GlyTouCan

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UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements