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chromosome 17 open reading frame 99

Summary

Gene Symbol

C17orf99

Organism

Homo sapiens (human)

External Links

NCBI Gene

100141515

PubChem

100141515

Alliance of Genome Resources

HGNC:34490

Annotation

Keyword

Adaptive immunity
Cytokine
Direct protein sequencing
Glycoprotein
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6UX52	Interleukin-40

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
adaptive immune response	IEA
mature B cell differentiation involved in immune response	ISS
immune response	IBA
cell surface receptor signaling pathway	IBA
positive regulation of immunoglobulin production in mucosal tissue	ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

immune response

adaptive immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

signal transduction [inference]

cell surface receptor signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response

response to stimulus [inference]

immune response

adaptive immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of leukocyte mediated immunity [inference]

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of lymphocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of leukocyte mediated immunity [inference]

positive regulation of lymphocyte mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

regulation of B cell mediated immunity [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of B cell mediated immunity [inference]

positive regulation of immunoglobulin mediated immune response [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

regulation of immunoglobulin production in mucosal tissue [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of immunoglobulin production [inference]

positive regulation of immunoglobulin production in mucosal tissue

Displaying **all 2** entries
GO Term	Evidence Code	PMID
extracellular space	IDA	28978694
external side of plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

side of membrane [inference]

external side of plasma membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IBA
cytokine activity	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

receptor ligand activity [inference]

cytokine activity

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

IL-40

Functional Category

L: Replication, recombination and repair
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying 1 entry
InterPro
IL-40-like, Ig domain

Ortholog

Displaying entries **1 - 10** of 13 in total

1

2

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Rattus norvegicus	77727	RGD:1591144
Pan troglodytes	454918		PANTR15547
Rattus norvegicus	688282		RATNO02400
Rattus norvegicus	100141515	RGD:1591144
Pongo abelii	100444318		PONAB12195
Nomascus leucogenys	100606615		NOMLE08699
Pan paniscus	100981310		PANPA18047
Ursus maritimus	103665783		URSMA11051
Rhinopithecus roxellana	104677018		RHIRO16026
Mandrillus leucophaeus	105545497		MANLE00260

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements