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phosphatase and actin regulator 4

Summary

Gene Symbol

Phactr4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

100169

PubChem

100169

Alliance of Genome Resources

MGI:2140327

Annotation

Keyword

Actin-binding
Alternative splicing
Cell projection
Cytoplasm
Developmental protein
Neurogenesis
Phosphoprotein
Protein phosphatase inhibitor
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q501J7	Protein Humpty dumpty

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
neural crest cell migration	IMP	22215812
neural crest cell migration	IBA
neural tube closure	IMP	17609112
Rho protein signal transduction	IMP	22215812
actin cytoskeleton organization	IMP	22215812

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

actin filament-based process [inference]

actin cytoskeleton organization

cell motility [inference]

cell migration [inference]

ameboidal-type cell migration [inference]

mesenchymal cell migration [inference]

neural crest cell migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an epithelial sheet [inference]

closure of optic fissure

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

system development [inference]

enteric nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction [inference]

Rho protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of integrin-mediated signaling pathway [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of integrin-mediated signaling pathway

regulation of cell cycle

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytoplasm	IEA
lamellipodium	IDA	22215812

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
actin binding	IDA	17609112
actin binding	IBA
protein phosphatase inhibitor activity	IEA
protein phosphatase 1 binding	IDA	17609112
protein phosphatase activator activity	IDA	17609112

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

cytoskeletal protein binding [inference]

actin binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding [inference]

protein phosphatase 1 binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

phosphatase regulator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

protein phosphatase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

phosphatase activator activity [inference]

protein phosphatase activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

phosphatase inhibitor activity [inference]

protein phosphatase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatase and actin regulator 4

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 10** entries
Gene Ontology
Rho protein signal transduction
actin binding
actin cytoskeleton organization
closure of optic fissure
enteric nervous system development
negative regulation of integrin-mediated signaling pathway
nervous system development
neural crest cell migration
neural tube closure
protein phosphatase 1 binding

Displaying 1 entry
InterPro
RPEL repeat

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Saccharomyces cerevisiae S288C	9749	SGD:S000005177
Homo sapiens	65979	Xenbase:XB-GENE-5930004	HUMAN48441
Xenopus tropicalis	100169	Xenbase:XB-GENE-5930004
Saccharomyces cerevisiae S288C	116154	SGD:S000005177
Saccharomyces cerevisiae S288C	218194	SGD:S000005177
Danio rerio	393643		DANRE11044
Pan troglodytes	456684		PANTR20427
Canis lupus familiaris	487333		CANLF06947
Bos taurus	514644		BOVIN25053
Rattus norvegicus	682920		RATNO32322