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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

neurofilament light chain

Summary

Gene Symbol

NEFL

Organism

Pongo abelii (Sumatran orangutan)

External Links

NCBI Gene: 100173482
PubChem: 100173482

Annotation

Keyword

Acetylation
Cell projection
Coiled coil
Cytoskeleton
Glycoprotein
Intermediate filament
Methylation
Phosphoprotein
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5R408	Neurofilament triplet L protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
microtubule cytoskeleton organization
axonogenesis
anterograde axonal transport
retrograde axonal transport
peripheral nervous system axon regeneration

GO Hierarchy

biological process

cellular process [inference]

microtubule-based process [inference]

microtubule cytoskeleton organization

microtubule-based movement [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

neuron apoptotic process [inference]

motor neuron apoptotic process

intermediate filament-based process [inference]

intermediate filament cytoskeleton organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly [inference]

neurofilament bundle assembly

neurofilament cytoskeleton organization

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

microtubule cytoskeleton organization

intermediate filament cytoskeleton organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly [inference]

neurofilament bundle assembly

neurofilament cytoskeleton organization

cellular component assembly [inference]

intermediate filament bundle assembly [inference]

neurofilament bundle assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

axon development [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

supramolecular fiber organization [inference]

intermediate filament organization [inference]

intermediate filament bundle assembly [inference]

neurofilament bundle assembly

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

neuromuscular process [inference]

neuromuscular process controlling balance

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

regeneration [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

locomotion

response to stimulus [inference]

response to stress [inference]

response to wounding [inference]

response to axon injury [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

cellular response to stimulus [inference]

cellular response to stress [inference]

neuron projection regeneration [inference]

axon regeneration [inference]

peripheral nervous system axon regeneration

localization [inference]

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

microtubule-based transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of localization in cell [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle localization [inference]

mitochondrion localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

establishment of organelle localization [inference]

establishment of mitochondrion localization [inference]

establishment of mitochondrion localization, microtubule-mediated [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

cellular localization [inference]

intracellular transport [inference]

cytoskeleton-dependent intracellular transport [inference]

transport along microtubule [inference]

axo-dendritic transport [inference]

axonal transport [inference]

organelle transport along microtubule [inference]

mitochondrion transport along microtubule [inference]

axonal transport of mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of axonogenesis [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of synapse maturation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of motor neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process [inference]

negative regulation of motor neuron apoptotic process

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of axonogenesis [inference]

regulation of synapse organization [inference]

regulation of synapse maturation

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of axonogenesis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of axonogenesis

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell projection size [inference]

regulation of axon diameter

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA	30032202
intermediate filament	IEA	22301074 30032202
neurofilament
axon	IEA	30032202
neuromuscular junction

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasmic region [inference]

plasma membrane bounded cell projection cytoplasm [inference]

neuron projection cytoplasm [inference]

axon cytoplasm

cell junction [inference]

synapse [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton [inference]

presynaptic cytoskeleton [inference]

presynaptic intermediate filament cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

intermediate filament cytoskeleton [inference]

presynaptic cytoskeleton [inference]

presynaptic intermediate filament cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic intermediate filament cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

neurofilament

Displaying **all 3** entries
GO Term	Evidence Code	PMID
protein-macromolecule adaptor activity
identical protein binding
structural constituent of postsynaptic intermediate filament cytoskeleton	IEA	30032202

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of cytoskeleton [inference]

structural constituent of postsynaptic intermediate filament cytoskeleton

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic intermediate filament cytoskeleton

binding [inference]

protein binding [inference]

identical protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Keratin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
intermediate filament organization

Displaying **all 2** entries
InterPro
Intermediate filament protein, conserved site
Intermediate filament, rod domain

Ortholog

Displaying entries **1 - 10** of 71 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	4747		HUMAN93060
Mus musculus	18039		MOUSE12892
Rattus norvegicus	83613		RATNO10439
Bos taurus	281348		BOVIN34763
Pan troglodytes	464063		PANTR42193
Macaca mulatta	641444		MACMU43938
Danio rerio	664698		DANRE42497
Monodelphis domestica	100020093		MONDO04912
Equus caballus	100054178		HORSE26921
Ornithorhynchus anatinus	100077288		ORNAN22600

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Last updated: April 7, 2025