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arachidonate 5-lipoxygenase

Summary

Gene Symbol

ALOX5

Organism

Taeniopygia guttata (zebra finch)

External Links

NCBI Gene: 100231888
KEGG Gene ID: tgu:100231888
PubChem: 100231888

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
xenobiotic metabolic process	IEA	30032202
lipoxygenase pathway	IEA	30032202
epoxygenase P450 pathway	IEA	30032202
lipid oxidation	IEA	30032202
linoleic acid metabolic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

lipoxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

xenobiotic metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

lipid modification [inference]

lipid oxidation

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

lipid modification [inference]

lipid oxidation

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

lipoxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

lipoxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipid metabolic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

lipid modification [inference]

lipid oxidation

olefinic compound metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

icosanoid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

lipoxygenase pathway

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

xenobiotic metabolic process

cellular biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

cellular lipid metabolic process [inference]

fatty acid metabolic process [inference]

long-chain fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

linoleic acid metabolic process

hepoxilin metabolic process [inference]

hepoxilin biosynthetic process

fatty acid biosynthetic process [inference]

long-chain fatty acid biosynthetic process [inference]

hepoxilin biosynthetic process

lipoxygenase pathway

unsaturated fatty acid metabolic process [inference]

arachidonic acid metabolic process [inference]

epoxygenase P450 pathway

linoleic acid metabolic process

lipid modification [inference]

lipid oxidation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nuclear envelope	IEA	30032202
cytoplasm	IEA	30032202
intracellular membrane-bounded organelle	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

intracellular organelle [inference]

intracellular membrane-bounded organelle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
arachidonate 5-lipoxygenase activity	IEA	30032202
iron ion binding	IEA	22301074
protein binding	IEA	22301074
arachidonic acid epoxygenase activity	IEA	30032202
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

monooxygenase activity [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

arachidonate 5-lipoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

arachidonic acid monooxygenase activity [inference]

arachidonic acid epoxygenase activity

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

dioxygenase activity [inference]

oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [inference]

arachidonate 5-lipoxygenase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lipoxygenase

Functional Category

P: Inorganic ion transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
dioxygenase activity
lipid metabolic process
lipid oxidation
metal ion binding
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
oxidoreductase activity

Displaying **all 7** entries
InterPro
Lipoxigenase, C-terminal domain superfamily
Lipoxygenase, C-terminal
Lipoxygenase, conserved site
Lipoxygenase, iron binding site
Lipoxygenase
PLAT/LH2 domain superfamily
PLAT/LH2 domain

KEGG BRITE Database

Orthology

K00461

Name

arachidonate 5-lipoxygenase [EC:1.13.11.34]

References

Ortholog

Displaying entries **1 - 10** of **250** in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	240	HUMAN00974
Homo sapiens	1557	HUMAN02247
Homo sapiens	1558	HUMAN02251
Homo sapiens	1559	HUMAN02249
Homo sapiens	1562	HUMAN02243
Mus musculus	11689	MOUSE50457
Mus musculus	13095	MOUSE25610
Mus musculus	13096	MOUSE25624
Mus musculus	13097	MOUSE25612
Mus musculus	13098	MOUSE25613

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

OrthoDB (Group)

KEGG BRITE Database

International Collaboration

Acknowledgements